968-P: Long-Term Quantitative and Qualitative Effect of Dulaglutide in Type 2 Diabetes Patients

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 968-P
Author(s):  
ANASTASIOS KOUTSOVASILIS ◽  
ALEXIOS SOTIROPOULOS ◽  
MARIA PAPPA ◽  
THEODOROS PEPPAS
Keyword(s):  
Type 2 Diabetes ◽  
Qualitative Effect ◽  
Diabetes Patients

1022-P: Quantitative and Qualitative Effect of Dulaglutide in Type 2 Diabetes Patients Under Treatment with Liraglutide

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1022-P
Author(s):  
ALEXIOS SOTIROPOULOS ◽  
ANASTASIOS KOUTSOVASILIS ◽  
ANASTASIA ANTONIOU ◽  
STAVROS BOUSBOULAS ◽  
THEODOROS PEPPAS
Keyword(s):  
Type 2 Diabetes ◽  
Qualitative Effect ◽  
Diabetes Patients

Switching to basal-bolus insulin therapy is effective and safe in long-term type 2 diabetes patients inadequately controlled with other insulin regimens

2013 ◽  
Vol 60 (5) ◽  
pp. 249-253
Author(s):  
Irene Vinagre ◽  
Juan Sánchez-Hernández ◽  
José Luis Sánchez-Quesada ◽  
Miguel Ángel María ◽  
Alberto de Leiva ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Therapy ◽  
Bolus Insulin ◽  
Basal Bolus ◽  
Term Type ◽  
Diabetes Patients

Metformin regulates TRPM6, a potential explanation for magnesium imbalance in type 2 diabetes patients

2020 ◽  
Vol 98 (6) ◽  
pp. 400-411 ◽  
Author(s):  
Hacene Bouras ◽  
Sara R. Roig ◽  
Steef Kurstjens ◽  
Cees J.J. Tack ◽  
Mohamed Kebieche ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cell Surface ◽  
Fine Tuning ◽  
Metformin Treatment ◽  
Long Term Effects ◽  
Short Term ◽  
Metformin Therapy ◽  
Diabetes Patients

Metformin therapy is associated with lower serum magnesium (Mg2+) levels in type 2 diabetes patients. The TRPM6 channel determines the fine-tuning of Mg2+ (re)absorption in intestine and kidney. Therefore, we aimed to investigate the short- and long-term effects of metformin on TRPM6. Patch clamp recordings and biotinylation assays were performed upon 1 h of incubation with metformin in TRPM6-transfected HEK293 cells. Additionally, 24 h of treatment of mDCT15 kidney and hCaco-2 colon cells with metformin was applied to measure the effects on endogenous TRPM6 expression by quantitative real-time PCR. To assess Mg2+ absorption, 25Mg2+ uptake measurements were performed using inductively coupled plasma mass spectrometry. Short-term effects of metformin significantly increased TRPM6 activity and its cell surface trafficking. In contrast, long-term effects significantly decreased TRPM6 mRNA expression and 25Mg2+ uptake. Metformin lowered TRPM6 mRNA levels independently of insulin- and AMPK-mediated pathways. Moreover, in type 2 diabetes patients, metformin therapy was associated with lower plasma Mg2+ concentrations and fractional excretion of Mg2+. Thereby, short-term metformin treatment increases TRPM6 activity explained by enhanced cell surface expression. Conversely, long-term metformin treatment results in downregulation of TRPM6 gene expression in intestine and kidney cells. This long-term effect translated in an inverse correlation between metformin and plasma Mg2+ concentration in type 2 diabetes patients.

Serum Leptin and Adiponectin Concentration in Type 2 Diabetes Patients in the Short and Long Term Following Biliopancreatic Diversion

2016 ◽  
Vol 26 (10) ◽  
pp. 2442-2448 ◽  
Author(s):  
Gian Franco Adami ◽  
Raffaella Gradaschi ◽  
Gabriella Andraghetti ◽  
Nicola Scopinaro ◽  
Renzo Cordera
Keyword(s):  
Type 2 Diabetes ◽  
Biliopancreatic Diversion ◽  
Adiponectin Concentration ◽  
Serum Leptin ◽  
Short And Long Term ◽  
Diabetes Patients

scholarly journals PDB30 COSTS AND ADHERENCE ASSOCIATED WITH LONG TERM USE OF THIAZOLIDINEDIONE THERAPY IN MEDICAID ENROLLED TYPE 2 DIABETES PATIENTS

2006 ◽  
Vol 9 (3) ◽  
pp. A40
Author(s):  
R Balkrishnan ◽  
R Shenolikar ◽  
R Rajagopalan ◽  
F Camacho ◽  
RT Anderson
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Patients

scholarly journals PDB41 Long-Term Evaluation of the Economic Impact of Reducing HbA1C by 1% in Type 2 Diabetes Patients in Algeria

2012 ◽  
Vol 15 (7) ◽  
pp. A500-A501
Author(s):  
P. Roca ◽  
L. Lamri ◽  
M. Belhadj ◽  
R.F. Pollock ◽  
W.J. Valentine ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Economic Impact ◽  
Term Evaluation ◽  
Diabetes Patients
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