844-P: Effects of Dapagliflozin, Metformin, or Exercise on Plasma Glucagon Concentrations in Individuals with Prediabetes: The PRE-D Trial

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 844-P
Author(s):  
KIM K.B. CLEMMENSEN ◽  
MARTIN B. BLOND ◽  
HANAN AMADID ◽  
LEA B. NIELSEN ◽  
DORTE VISTISEN ◽  
...  
Keyword(s):  
Plasma Glucagon

Effects of acute insulin withdrawal and administration on plasma glucagon responses to intravenous arginine in insulin-dependent diabetic subjects

Diabetes ◽  
1976 ◽  
Vol 25 (10) ◽  
pp. 955-960 ◽  
Author(s):  
J. E. Gerich ◽  
M. Lorenzi ◽  
E. Tsalikian ◽  
N. V. Bohannon ◽  
V. Schneider ◽  
...  
Keyword(s):  
Plasma Glucagon ◽  
Insulin Withdrawal ◽  
Insulin Dependent ◽  
Insulin Dependent Diabetic

Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentration

Diabetes ◽  
1995 ◽  
Vol 44 (2) ◽  
pp. 185-189 ◽  
Author(s):  
I. Magnusson ◽  
D. L. Rothman ◽  
D. P. Gerard ◽  
L. D. Katz ◽  
G. I. Shulman
Keyword(s):  
Glucose Production ◽  
Plasma Glucagon ◽  
Glucagon Concentration

Study of Possible Relation between Fasting Plasma Glucagon, Gestational Diabetes and Development of Type 2 DM

2020 ◽  
Vol 16 (2) ◽  
pp. 148-155 ◽  
Author(s):  
Ashraf Okba ◽  
Salwa Seddik Hosny ◽  
Alyaa Elsherbeny ◽  
Manal Mohsin Kamal
Keyword(s):  
Gestational Diabetes ◽  
Pregnant Women ◽  
Post Partum ◽  
Plasma Glucagon ◽  
Type 2 Dm ◽  
Fasting Plasma ◽  
Before And After ◽  
Two Phases

Background and Aims: Women who develop GDM (gestational diabetes mellitus) have a relative insulin secretion deficiency, the severity of which may be predictive for later development of diabetes. This study aimed to investigate the role of fasting plasma glucagon in the prediction of later development of diabetes in pregnant women with GDM. Materials and Methods: The study was conducted on 150 pregnant women with GDM after giving informed oral and written consents and being approved by the research ethical committee according to the declaration of Helsinki. The study was conducted in two phases, first phase during pregnancy and the second one was 6 months post-partum, as we measured fasting plasma glucagon before and after delivery together with fasting and 2 hour post-prandial plasma sugar. Results: Our findings suggested that glucagon levels significantly increased after delivery in the majority 14/25 (56%) of GDM women who developed type 2 DM within 6 months after delivery compared to 6/20 (30%) patients with impaired fasting plasma glucose (IFG) and only 22/105 (20%) non DM women, as the median glucagon levels were 80,76, 55, respectively. Also, there was a high statistical difference between fasting plasma glucagon post-delivery among diabetic and non-diabetic women (p ≤ 0.001). These results indicated the useful role of assessing fasting plasma glucagon before and after delivery in patients with GDM to predict the possibility of type 2 DM. Conclusion: There is a relatively high glucagon level in GDM patients, which is a significant pathogenic factor in the incidence of subsequent diabetes in women with a history of GDM. This could be important in the design of follow-up programs for women with previous GDM.

Changes in plasma glucagon and insulin associated with fasting in sea bass (Dicentrarchus labrax)

1991 ◽  
Vol 9 (2) ◽  
pp. 107-112 ◽  
Author(s):  
J. Gutiérrez ◽  
J. Pérez ◽  
I. Navarro ◽  
S. Zanuy ◽  
M. Carrillo
Keyword(s):  
Dicentrarchus Labrax ◽  
Sea Bass ◽  
Plasma Glucagon ◽  
Glucagon And Insulin

Failure to Suppress Plasma Glucagon Concentrations by Orally Administered Glucose in Diabetic Patients After Treatment

Diabetes ◽  
1978 ◽  
Vol 27 (12) ◽  
pp. 1145-1150 ◽  
Author(s):  
Y. Seino ◽  
M. Ikeda ◽  
H. Kurahachi ◽  
T. Taminato ◽  
H. Sakurai ◽  
...  
Keyword(s):  
Diabetic Patients ◽  
Plasma Glucagon

Oral sensory stimulation improves glucose tolerance in humans: effects on insulin, C-peptide, and glucagon

1996 ◽  
Vol 270 (6) ◽  
pp. R1371-R1379 ◽  
Author(s):  
K. L. Teff ◽  
K. Engelman
Keyword(s):  
Glucose Metabolism ◽  
Glucose Tolerance ◽  
Area Under The Curve ◽  
Sensory Stimulation ◽  
Sampling Period ◽  
Intragastric Administration ◽  
Plasma Glucagon ◽  
C Peptide ◽  
Oral Sensory ◽  
Normal Glucose

In animals, bypassing the oropharyngeal receptors by intragastric administration of glucose results in glucose intolerance. To determine whether the absence of oral sensory stimulation alters glucose tolerance in humans, we monitored plasma levels of glucose and hormones after intragastric administration of glucose, with and without subjects tasting food. Plasma glucose area under the curve (AUC) was significantly lower after oral sensory stimulation (3,433 +/- 783 vs. 5,643 +/- 1,397 mg.dl-1. 195 min-1; P < 0.03; n = 8). Insulin and C-peptide AUCs were higher during the first one-half of the sampling period (insulin, 5,771 +/- 910 vs. 4,295 +/- 712 microU. ml-1.75 min-1; P < 0.05; C-peptide, 86 +/- 10 vs. 66 +/- 9 ng.ml-1. 75 min-1; P < 0.03) and lower during the second one-half of the sampling period compared with the control condition (1,010 +/- 233 vs. 2,106 microU.ml-1. 120 min-1; P < 0.025; 31 +/- 8 vs. 56 +/- 18 ng.ml-1. 120 min-1; P < 0.05; insulin and C-peptide, respectively). Oral sensory stimulation markedly increased plasma glucagon compared with the control condition (1,258 +/- 621 vs. -2,181 +/- 522 pg.ml-1. 195 min-1; P < 0.002). These data provide evidence in humans that oral sensory stimulation influences glucose metabolism and suggest that the mechanisms elicited by this cephalic stimulation are necessary for normal glucose homeostasis.

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