446-P: Skin Autofluorescence, a Measure of Advanced Glycation End Products, and Diabetes Complications: Meta-analysis and Systematic Review

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 446-P
Author(s):  
YOUSSEF KOUIDRAT
Keyword(s):  
Systematic Review ◽  
Advanced Glycation End Products ◽  
Diabetes Complications ◽  
Meta Analysis ◽  
Skin Autofluorescence ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

scholarly journals The relationship between advanced glycation end products and gestational diabetes: A systematic review and meta-analysis

PLoS ONE ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. e0240382
Author(s):  
Mekonnen Sisay ◽  
Dumessa Edessa ◽  
Tilahun Ali ◽  
Abraham Nigussie Mekuria ◽  
Alemu Gebrie
Keyword(s):  
Systematic Review ◽  
Gestational Diabetes ◽  
Advanced Glycation End Products ◽  
Meta Analysis ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
The Relationship

scholarly journals Advanced Glycation End-Products in Common Non-Infectious Liver Diseases: Systematic Review and Meta-Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3370
Author(s):  
Kamil Litwinowicz ◽  
Ewa Waszczuk ◽  
Andrzej Gamian
Keyword(s):  
Systematic Review ◽  
Liver Disease ◽  
Diagnostic Accuracy ◽  
Advanced Glycation End Products ◽  
Meta Analysis ◽  
Healthy Controls ◽  
Advanced Glycation ◽  
Alcoholic Fatty Liver ◽  
Glycation End Products ◽  
End Products

Background: Excessive intake of fructose, glucose and alcohol is associated with the development of non-alcoholic fatty liver disease (NAFLD) and alcoholic liver disease (ALD). At the same time, these dietetic factors create an environment favorable for the generation of advanced glycation end-products. For this reason, advanced glycation end-products (AGEs) are hypothesized to play role in the development of NAFLD and ALD. In this systematic review and meta-analysis, we explore the relationship between NAFLD and ALD with AGE levels, including their diagnostic accuracy. Methods: The systematic review and meta-analysis has been pre-registered with PROSPERO (CRD42021240954) and was performed in accordance with the PRISMA guidelines. Meta-analyses were performed using the meta R package. Results: We have obtained 11 studies meeting our inclusion criteria, reporting data on 1844 participants (909 with NAFLD, 169 with ALD and 766 healthy controls). NAFLD was associated with significantly higher AGE fluorescence and serum N-(carboxyethyl)lysine (CEL) levels. Patients with alcoholic cirrhosis had significantly higher levels of N-(carboxymethyl)lysine (CML). Only individual studies examined AGEs in the context of their diagnostic accuracy. AGE fluorescence distinguished low and moderate steatosis with an AUC of 0.76. The ratio of CML, CEL and pentosidine to a soluble variant of the AGE receptor differentiated patients with NAFLD from healthy controls with high AUC (0.83–0.85). Glyceraldehyde-derived AGE separated non-alcoholic fatty liver (NAFL) from non-alcoholic steatohepatitis (NASH) with acceptable performance (AUC 0.78). Conclusions: In conclusion, NAFLD and ALD are associated with significantly higher levels of several AGEs. More research is needed to examine the diagnostic accuracy of AGEs, however individual studies show that AGEs perform well in distinguishing NAFL from NASH.

scholarly journals The impact of low advanced glycation end products diet on obesity and related hormones: a systematic review and meta-analysis

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Mohammad Hassan Sohouli ◽  
Elham Sharifi-Zahabi ◽  
Abolfazl Lari ◽  
Somaye Fatahi ◽  
Farzad Shidfar
Keyword(s):  
Systematic Review ◽  
Systematic Reviews ◽  
Advanced Glycation End Products ◽  
Randomized Clinical Trials ◽  
Meta Analysis ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
High Age ◽  
The Impact

AbstractSeveral randomized clinical trials (RCTs) have investigated the effect of dietary advanced glycation end products (AGE) on obesity factors and related hormones in adults; results were conflicting. Therefore, a study was performed to assess the effect of low advanced glycation end products diet on obesity and related hormones. A comprehensive literature search without any limitation on language was conducted using the following bibliographical databases: Web of Science, Scopus, Ovid MEDLINE, Cochrane, and Embase up to October, 2019. From the eligible trials, 13 articles were selected for the systematic review and meta-analysis. Our systematic reviews and meta-analyses have shown a significant decrease in BMI (WMD: − 0.3 kg/m2; 95% CI: − 0.52, − 0.09, p = 0.005; I2 = 55.8%), weight (WMD: − 0.83 kg; 95% CI: − 1.55, − 0.10, p = 0.026; I2 = 67.0%), and leptin (WMD: − 19.85 ng/ml; 95% CI: − 29.88, − 9.82, p < 0.001; I2 = 81.8%) and an increase in adiponectin (WMD: 5.50 µg/ml; 95% CI: 1.33, 9.67, p = 0.010; I2 = 90.6%) levels after consumption of the low AGE diets compared to the high AGE diets. Also, the effect of intake of low AGE compared to high AGE diets was more pronounced in subgroup with duration > 8 weeks for the BMI and weight. Overall, according to our results, although low AGE diets appeared to be statistically significant in reducing the prevalence of obesity and chronic diseases compared to high consumption of dietary AGEs. But, no clinical significance was observed. Therefore, to confirm these results clinically, further prospective studies should be conducted in this regard. The study protocol was registered in the in International prospective register of systematic reviews (PROSPERO) database as CRD42020203734.

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