436-P: Characterization of Autoimmunity in the Acceleration of Atherosclerosis in Type 1 Diabetes

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 436-P
Author(s):  
KYOUNGMIN PARK ◽  
QIAN LI ◽  
HYUNSEOK PARK ◽  
RONALD ST-LOUIS ◽  
JIALIN FU ◽  
...  
Keyword(s):  
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...  
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PLoS ONE ◽  
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Vol 14 (1) ◽  
pp. e0210839 ◽  
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Antonino Crinò ◽  
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2009 ◽  
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pp. 150-158 ◽  
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Rashid Ali

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1056-P
Author(s):  
DANA M. LEWIS ◽  
AZURE D. GRANT

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 98-OR
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THOMAS DELONG ◽  
PETER GOTTLIEB ◽  
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Matthew D. Campbell ◽  
Jana Urbanová ◽  
Marisa A. Nunes ◽  
Ludmila Brunerová ◽  
...  

The glycemic response to ingested glucose for the treatment of hypoglycemia following exercise in type 1 diabetes patients has never been studied. Therefore, we aimed to characterize glucose dynamics during a standardized bout of hypoglycemia-inducing exercise and the subsequent hypoglycemia treatment with the oral ingestion of glucose. Ten male patients with type 1 diabetes performed a standardized bout of cycling exercise using an electrically braked ergometer at a target heart rate (THR) of 50% of the individual heart rate reserve, determined using the Karvonen equation. Exercise was terminated when hypoglycemia was reached, followed by immediate hypoglycemia treatment with the oral ingestion of 20 g of glucose. Arterialized blood glucose (ABG) levels were monitored at 5 min intervals during exercise and for 60 min during recovery. During exercise, ABG decreased at a mean rate of 0.11 ± 0.03 mmol/L·min−1 (minimum: 0.07, maximum: 0.17 mmol/L·min−1). During recovery, ABG increased at a mean rate of 0.13 ± 0.05 mmol/L·min−1 (minimum: 0.06, maximum: 0.19 mmol/L·min−1). Moreover, 20 g of glucose maintained recovery from hypoglycemia throughout the 60 min postexercise observation window.


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