153-OR: Glucose-Dependency of Insulinotropic and Glucagonostatic Effects of Glucagon-Like Peptide-1 after Gastric Bypass and Sleeve Gastrectomy

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 153-OR
Author(s):  
HENRI HONKA ◽  
ANAS M. AL ZUBAIDI ◽  
AMALIA GASTALDELLI ◽  
RALPH A. DEFRONZO ◽  
MARZIEH SALEHI
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Effect of Sleeve Gastrectomy, Roux-En-Y Gastric Bypass, and Ileal Transposition on Myocardial Ischaemia–Reperfusion Injury in Non-Obese Non-Diabetic Rats

2021 ◽  
Author(s):  
Oleg Kornyushin ◽  
Dmitry Sonin ◽  
Alexander Polozov ◽  
Vitaly Masley ◽  
Nika Bulavinova ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Diabetic Rats ◽  
Ischaemia Reperfusion Injury ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Mediated Reduction

Abstract Bariatric surgery (BS) improves outcomes in patients with myocardial infarction (MI). Here we tested the hypothesis that BS-mediated reduction in fatal MI could be attributed to its infarct-limiting effect. Wistar rats were randomized into five groups: control (CON), sham (SHAM), Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), and ileotransposition (IT). Ten weeks later, animals were subjected to 30-min myocardial ischemia plus 120-min reperfusion. Infarct size (IS) and no-reflow zone (NRZ) were determined histochemically. Fasting plasma levels of glucagon-like peptide-1 (GLP-1), leptin, ghrelin, and insulin were measured using ELISA. Compared with SHAM, RYGB and SG reduced IS by 22% (p = 0.011) and 10% (p = 0.027), and NRZ by 38% (p = 0.01) and 32% (p = 0.004), respectively. IT failed to reduce IS and NRZ. GLP1 level was increased in the SG and RYGB groups compared with CON. In both the SG and RYGB, leptin level was decreased compared with CON and SHAM. In the SG group, ghrelin level was lower than that in the CON and SHAM. Insulin levels were not different between groups. In conclusion, RYGB and SG increased myocardial tolerance to ischemia–reperfusion injury of non-obese, non-diabetic rats, and their infarct-limiting effect is associated with decreased leptin and ghrelin levels and increased GLP-1 level.

GLP-1: A Mediator of the Beneficial Metabolic Effects of Bariatric Surgery?

Physiology ◽  
2015 ◽  
Vol 30 (1) ◽  
pp. 50-62 ◽  
Author(s):  
Sean Manning ◽  
Andrea Pucci ◽  
Rachel L. Batterham
Keyword(s):  
Bariatric Surgery ◽  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Gut Hormones ◽  
Metabolic Effects ◽  
Physiological Changes ◽  
Gut Hormone ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

There has been increasing interest in the role that gut hormones may play in contributing to the physiological changes produced by certain bariatric procedures, such as Roux-en-Y gastric bypass and sleeve gastrectomy. Here, we review the evidence implicating one such gut hormone, glucagon-like peptide-1, as a mediator of the metabolic benefits of these two procedures.

scholarly journals Effect of sleeve gastrectomy, Roux-en-Y gastric bypass, and ileal transposition on myocardial ischaemia–reperfusion injury in non-obese non-diabetic rats

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Oleg Kornyushin ◽  
Dmitry Sonin ◽  
Alexander Polozov ◽  
Vitaly Masley ◽  
Nika Bulavinova ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Sleeve Gastrectomy ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Diabetic Rats ◽  
Ischaemia Reperfusion Injury ◽  
No Reflow ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

AbstractBariatric surgery (BS) improves outcomes in patients with myocardial infarction (MI). Here we tested the hypothesis that BS-mediated reduction in fatal MI could be attributed to its infarct-limiting effect. Wistar rats were randomized into five groups: control (CON), sham (SHAM), Roux-en-Y gastric bypass (RYGB), sleeve gastrectomy (SG), and ileotransposition (IT). Ten weeks later, animals were subjected to 30-min myocardial ischemia plus 120-min reperfusion. Infarct size (IS) and no-reflow area were determined histochemically. Fasting plasma levels of glucagon-like peptide-1 (GLP-1), leptin, ghrelin, and insulin were measured using ELISA. Compared with SHAM, RYGB and SG reduced IS by 22% (p = 0.011) and 10% (p = 0.027), and no-reflow by 38% (p = 0.01) and 32% (p = 0.004), respectively. IT failed to reduce IS and no-reflow. GLP-1 level was increased in the SG and RYGB groups compared with CON. In both the SG and RYGB, leptin level was decreased compared with CON and SHAM. In the SG group, ghrelin level was lower than that in the CON and SHAM. Insulin levels were not different between groups. In conclusion, RYGB and SG increased myocardial tolerance to ischemia–reperfusion injury of non-obese, non-diabetic rats, and their infarct-limiting effect is associated with decreased leptin and ghrelin levels and increased GLP-1 level.

Peptide YY and glucagon-like peptide-1 contribute to decreased food intake after Roux-en-Y gastric bypass surgery

2016 ◽  
Vol 40 (11) ◽  
pp. 1699-1706 ◽  
Author(s):  
M S Svane ◽  
N B Jørgensen ◽  
K N Bojsen-Møller ◽  
C Dirksen ◽  
S Nielsen ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Food Intake ◽  
Bypass Surgery ◽  
Peptide Yy ◽  
Gastric Bypass Surgery ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Contribution of Endogenous Glucagon-Like Peptide 1 to Glucose Metabolism After Roux-en-Y Gastric Bypass

Diabetes ◽  
2013 ◽  
Vol 63 (2) ◽  
pp. 483-493 ◽  
Author(s):  
M. Shah ◽  
J. H. Law ◽  
F. Micheletto ◽  
M. Sathananthan ◽  
C. Dalla Man ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Glucose Metabolism ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

Exaggerated release and preserved insulinotropic action of glucagon-like peptide-1 underlie insulin hypersecretion in glucose-tolerant individuals after Roux-en-Y gastric bypass

Diabetologia ◽  
2013 ◽  
Vol 56 (12) ◽  
pp. 2679-2687 ◽  
Author(s):  
Carsten Dirksen ◽  
Kirstine N. Bojsen-Møller ◽  
Nils B. Jørgensen ◽  
Siv H. Jacobsen ◽  
Viggo B. Kristiansen ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Glucose Tolerant ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Effects of Roux-en-Y gastric bypass on energy and glucose homeostasis are preserved in two mouse models of functional glucagon-like peptide-1 deficiency

2014 ◽  
Vol 3 (2) ◽  
pp. 191-201 ◽  
Author(s):  
Mohamad Mokadem ◽  
Juliet F. Zechner ◽  
Robert F. Margolskee ◽  
Daniel J. Drucker ◽  
Vincent Aguirre
Keyword(s):  
Gastric Bypass ◽  
Mouse Models ◽  
Glucose Homeostasis ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1
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