129-LB: Evaluation of Attitudes towards Two Glucagon Delivery Devices for Rescue Treatment of Severe Hypoglycemia

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 129-LB
Author(s):  
SANJAY K. BAJPAI ◽  
JANELLE CAMBRON-MELLOTT ◽  
NEDINA K. RAIBULET ◽  
EUGENIA Y. PECK ◽  
JIAT LING POON ◽  
...  
Keyword(s):  
Severe Hypoglycemia ◽  
Rescue Treatment

scholarly journals Comparison of a ready-to-use liquid glucagon injection administered by autoinjector to glucagon emergency kit for the symptomatic relief of severe hypoglycemia: two randomized crossover non-inferiority studies

2021 ◽  
Vol 9 (1) ◽  
pp. e002137
Author(s):  
Mark P Christiansen ◽  
Martin Cummins ◽  
Steven Prestrelski ◽  
Nicole C Close ◽  
Anh Nguyen ◽  
...  
Keyword(s):  
Plasma Glucose ◽  
Symptom Relief ◽  
Severe Hypoglycemia ◽  
Phase Iii ◽  
Tolerability Profile ◽  
Drug Preparation ◽  
Link Type ◽  
Rescue Treatment ◽  
Glucagon Injection ◽  
Mean Time

IntroductionTo prevent medical sequelae of severe hypoglycemic emergencies, prompt and reliable rescue intervention is critically important. A ready-to-use, liquid stable glucagon, administered subcutaneously by glucagon autoinjector (GAI), Gvoke HypoPen (glucagon injection; Xeris Pharmaceuticals), was evaluated for rescue treatment of severe hypoglycemia.Research design and methodsTwo phase III, randomized, controlled, blinded, non-inferiority crossover studies were conducted in 161 adults with type 1 diabetes to compare 1 mg doses of GAI versus glucagon emergency kit (GEK) for treating insulin-induced severe hypoglycemia. Efficacy was evaluated as either a return of plasma glucose to >70 mg/dL (3.9 mmol/L) or increase ≥20 mg/dL (1.1 mmol/L) from a baseline glucose of <50 mg/dL (2.9 mmol/L), within 30 min of dosing.ResultsFor successful plasma glucose recovery within 30 min, treatment with GAI was non-inferior to GEK. Treatment with GAI was non-inferior to GEK for a plasma glucose >70 mg/dL (3.9 mmol/L) or neuroglycopenic symptom relief within 30 min. From administration of glucagon, the mean time to achieve plasma glucose >70 mg/dL (3.9 mmol/L) or increase ≥20 mg/dL (1.1 mmol/L) was 13.8±5.6 min for GAI and 10.0±3.6 min for GEK. This mean time does not account for the significantly shorter (p<0.0001) drug preparation and administration time for GAI (27.3±19.7 s) versus GEK (97.2±45.1 s). The incidence of treatment emergent adverse events was comparable in both groups.ConclusionsA ready-to-use GAI was non-inferior to GEK, with a similar tolerability profile. GAI is an effective, safe, and well-tolerated rescue treatment for severe hypoglycemia and is a viable alternative to GEK.Trial registration numbersNCT02656069 and NCT03439072.

Silver Staining of Pancreatic Islets as Revealed by Electron Microscopy

1967 ◽  
Vol 25 ◽  
pp. 44-45
Author(s):  
Kazuaki Misugi ◽  
Nobuko Misugi ◽  
Hiroshi Yamada
Keyword(s):  
Pancreatic Islet ◽  
Silver Staining ◽  
Islet Cells ◽  
Severe Hypoglycemia ◽  
Granular Cell ◽  
Electron Microscopic Level ◽  
Staining Reaction ◽  
Electron Microscopic ◽  
Pancreatic Islet Cell ◽  
D Cell

The authors had described the fine structure of a type of pancreatic islet cell, which appeared different from typical alpha and beta cells, and tentatively considered that this third type of granular cell probably represents the D cell (Figure 1).Since silver staining has been widely used to differentiate different types of pancreatic islet cells by light microscopy, an attempt to examine this staining reaction at the electron microscopic level was made.Material and Method: Surgically removed specimens from three infants who suffered from severe hypoglycemia were used. The specimens were fixed and preserved in 20% neutral formalin. Frozen sections, 30 to 40 micron thick, were prepared and they were stained by Bielschowsky's method as modified by Suzuki (2). The stained sections were examined under a microscope and islet tissues were isolated. They were fixed in 1% osmium tetroxide in phosphate buffer for one hour and embedded in Epon 812 following dehydration through a series of alcohols and propylene oxide.

Characterization of the episodes of severe hypoglycemia evaluated by a pre-hospital care unit of a reference hospital

2014 ◽  
Author(s):  
Cesar Esteves ◽  
Manuel Celestino Neves ◽  
Rui Baldaia ◽  
Joao Sa ◽  
Davide Carvalho
Keyword(s):  
Hospital Care ◽  
Severe Hypoglycemia ◽  
Reference Hospital

Characterization of severe hypoglycemia episodes evaluated in the emergency department of a central hospital

2014 ◽  
Author(s):  
Cesar Esteves ◽  
Manuel Celestino Neves ◽  
Rui Baldaia ◽  
Joao Sa ◽  
Davide Carvalho
Keyword(s):  
Emergency Department ◽  
Severe Hypoglycemia ◽  
Central Hospital

Short and long-term glycemic variability associated with severe hypoglycemia and retinopathy in type 1 diabetes mellitus

2020 ◽  
Author(s):  
Martín Borja Sanz ◽  
Gimeno Sergio Roman ◽  
Peteiro Miranda Carlos Miguel ◽  
Ortez Toro Jose Jorge ◽  
Ana Agudo ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Severe Hypoglycemia ◽  
Glycemic Variability ◽  
Short And Long Term
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