scholarly journals Vaccination against receptor for advanced glycation end products attenuates the progression of diabetic kidney disease

Diabetes ◽  
2021 ◽  
pp. db201257
Author(s):  
Tatsuhiko Azegami ◽  
Takashin Nakayama ◽  
Kaori Hayashi ◽  
Akihito Hishikawa ◽  
Norifumi Yoshimoto ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Advanced Glycation End Products ◽  
Diabetic Kidney Disease ◽  
Advanced Glycation ◽  
Diabetic Kidney ◽  
Glycation End Products ◽  
End Products

scholarly journals ACTIVE IMMUNOTHERAPY AGAINST RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS ATTENUATES THE PROGRESSION OF DIABETIC KIDNEY DISEASE

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e303
Author(s):  
Tatsuhiko Azegami ◽  
Kaori Hayashi ◽  
Akihito Hishikawa ◽  
Norifumi Yoshimoto ◽  
Takashin Nakayama ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Advanced Glycation End Products ◽  
Diabetic Kidney Disease ◽  
Active Immunotherapy ◽  
Advanced Glycation ◽  
Diabetic Kidney ◽  
Glycation End Products ◽  
End Products

scholarly journals The AGE receptor, OST48 drives podocyte foot process effacement and basement membrane expansion in experimental diabetic kidney disease via promotion of endoplasmic reticulum stress

2019 ◽  
Author(s):  
Aowen Zhuang ◽  
Felicia YT Yap ◽  
Domenica McCarthy ◽  
Sally A. Penfold ◽  
Karly C. Sourris ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Kidney Disease ◽  
Endoplasmic Reticulum Stress ◽  
Advanced Glycation End Products ◽  
Diabetic Kidney Disease ◽  
Advanced Glycation ◽  
Diabetic Kidney ◽  
Glycation End Products ◽  
End Products ◽  
Foot Process

AbstractThe accumulation of advanced glycation end products is implicated in the development and progression of diabetic kidney disease. No study has examined whether stimulating advanced glycation clearance via receptor manipulation is reno-protective in diabetes. Podocytes, which are early contributors to diabetic kidney disease and could be a target for reno-protection. To examine the effects of increased podocyte oligosaccharyltransferase-48 on kidney function, glomerular sclerosis, tubulointerstitial fibrosis and proteome (PXD011434), we generated a mouse with increased oligosaccharyltransferase-48kDa subunit abundance in podocytes driven by the podocin promoter. Despite increased urinary clearance of advanced glycation end products, we observed a decline in renal function, significant glomerular damage including glomerulosclerosis, collagen IV deposition, glomerular basement membrane thickening and foot process effacement and tubulointerstitial fibrosis. Analysis of isolated glomeruli identified enrichment in proteins associated with collagen deposition, endoplasmic reticulum stress and oxidative stress. Ultra-resolution microscopy of podocytes revealed denudation of foot processes where there was co-localization of oligosaccharyltransferase-48kDa subunit and advanced glycation end-products. These studies indicate that increased podocyte expression of oligosaccharyltransferase-48kDa subunit results in glomerular endoplasmic reticulum stress and a decline in kidney function.

scholarly journals Role of advanced glycation end products in the onset of diabetic kidney disease complications

2017 ◽  
Vol 37 (4) ◽  
pp. 341-348
Author(s):  
Maria Luiza Almeida de Paula ◽  
Ana Marina Rodrigues Villela ◽  
Mauricio Massucati Negri ◽  
Salim Kanaan ◽  
Luciene de Carvalho Cardoso Weide
Keyword(s):  
Kidney Disease ◽  
Advanced Glycation End Products ◽  
Diabetic Kidney Disease ◽  
Advanced Glycation ◽  
Diabetic Kidney ◽  
Glycation End Products ◽  
End Products

scholarly journals Advanced Glycation End Products Predict Loss of Renal Function and Correlate With Lesions of Diabetic Kidney Disease in American Indians With Type 2 Diabetes

Diabetes ◽  
2016 ◽  
Vol 65 (12) ◽  
pp. 3744-3753 ◽  
Author(s):  
Pierre-Jean Saulnier ◽  
Kevin M. Wheelock ◽  
Scott Howell ◽  
E. Jennifer Weil ◽  
Stephanie K. Tanamas ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Renal Function ◽  
Kidney Disease ◽  
American Indians ◽  
Advanced Glycation End Products ◽  
Diabetic Kidney Disease ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products

Dietary Advanced Glycation End Products and Risk of Chronic Kidney Disease

2016 ◽  
Vol 26 (5) ◽  
pp. 308-314 ◽  
Author(s):  
Hanieh-Sadat Ejtahed ◽  
Pooneh Angoorani ◽  
Golaleh Asghari ◽  
Parvin Mirmiran ◽  
Fereidoun Azizi
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products
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