102-LB: Cross-Study Comparisons Done Right: An Illustration Using Two Pivotal Trials of Closed-Loop Systems

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 102-LB
Author(s):  
MARC D. BRETON ◽  
ROY BECK ◽  
RICHARD M. BERGENSTAL ◽  
BORIS KOVATCHEV
Keyword(s):  
Closed Loop ◽  
Closed Loop Systems

METHOD OF SYNTHESIS OF CLOSED-LOOP SYSTEMS OF ACTIVE SHIELDING MAGNETIC FIELD OF POWER TRANSMISSION LINES

2016 ◽  
Vol 2016 (4) ◽  
pp. 8-10 ◽  
Author(s):  
B.I. Kuznetsov ◽  
◽  
A.N. Turenko ◽  
T.B. Nikitina ◽  
A.V. Voloshko ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Transmission Lines ◽  
Closed Loop ◽  
Power Transmission ◽  
Power Transmission Lines ◽  
Closed Loop Systems ◽  
Active Shielding

Time in range for multiple technologies in type 1 diabetes: a systematic review and network meta-analysis

2020 ◽  
Author(s):  
Anthony Pease ◽  
Clement Lo ◽  
Arul Earnest ◽  
Velislava Kiriakova ◽  
Danny Liew ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 1 Diabetes ◽  
Closed Loop ◽  
Meta Analysis ◽  
Management Strategies ◽  
Glucose Testing ◽  
Closed Loop Systems ◽  
Percent Time ◽  
Time In Range

<b>Background: </b>Time-in-range is a key glycaemic metric, and comparisons of management technologies for this outcome are critical to guide device selection. <p><b> </b></p> <p><b>Purpose: </b>We conducted a systematic review and network meta-analysis to compare and rank technologies for time in glycaemic ranges.</p> <p> </p> <p><b>Data sources: </b>We searched All Evidenced Based Medicine Reviews, CINAHL, EMBASE, MEDLINE, MEDLINE In-Process and other non-indexed citations, PROSPERO, PsycINFO, PubMed, and Web of Science until 24 April, 2019.</p> <p> </p> <p><b>Study selection: </b>We included randomised controlled trials <u>></u>2 weeks duration comparing technologies for management of type 1 diabetes in adults (<u>></u>18 years of age), excluding pregnant women. </p> <p> </p> <p><b>Data extraction: </b>Data were extracted using a predefined template. Outcomes were percent time with sensor glucose levels 3.9–10.0mmol/l (70–180mg/dL), >10.0mmol/L (180mg/dL), and <3.9mmol/L (70mg/dL). </p> <p><b> </b></p> <p><b>Data synthesis: </b>We identified 16,772 publications, of which 14 eligible studies compared eight technologies comprising 1,043 participants. Closed loop systems lead to greater percent time-in-range than any other management strategy and was 17.85 (95% predictive interval [PrI] 7.56–28.14) higher than usual care of multiple daily injections with capillary glucose testing. Closed loop systems ranked best for percent time-in-range or above range utilising surface under the cumulative ranking curve (SUCRA–98.5 and 93.5 respectively). Closed loop systems also ranked highly for time below range (SUCRA–62.2). </p> <p><b> </b></p> <p><b>Limitations: </b>Overall risk of bias ratings were moderate for all outcomes. Certainty of evidence was very low.</p> <p><b> </b></p> <p><b>Conclusions: </b>In the first integrated comparison of multiple management strategies considering time-in-range, we found that the efficacy of closed loop systems appeared better than all other approaches. </p>

State Feedback Robust H∞ Control for Generalized Discrete System and Simulation

2013 ◽  
Vol 467 ◽  
pp. 621-626
Author(s):  
Chen Fang ◽  
Jiang Hong Shi ◽  
Kun Yu Li ◽  
Zheng Wang
Keyword(s):  
Discrete System ◽  
State Feedback ◽  
Closed Loop ◽  
The State ◽  
Linear Matrix ◽  
Sufficient Condition ◽  
Matrix Inequalities ◽  
Parameter Uncertainties ◽  
Robust Controller ◽  
Closed Loop Systems

For a class of uncertain generalized discrete linear system with norm-bounded parameter uncertainties, the state feedback robust control problem is studied. One sufficient condition for the solvability of the problem and the state feedback robust controller are obtained in terms of linear matrix inequalities. The designed controller guarantees that the closed-loop systems is regular, causal, stable and satisfies a prescribed norm bounded constraint for all admissible uncertain parameters under some conditions. The result of the normal discrete system can be regarded as a particular form of our conclusion. A simulation example is given to demonstrate the effectiveness of the proposed method.

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