scholarly journals Deficits in the Skeletal Muscle Transcriptome and Mitochondrial Coupling in Progressive Diabetes-Induced CKD Relate to Functional Decline

Diabetes ◽  
2021 ◽  
pp. db200688
Author(s):  
Daniel C. Bittel ◽  
Adam J. Bittel ◽  
Arun S. Varadhachary ◽  
Terri Pietka ◽  
David R. Sinacore
Keyword(s):  
Skeletal Muscle ◽  
Functional Decline ◽  
Skeletal Muscle Transcriptome

scholarly journals Drastic reduction of calsequestrin-like proteins and impaired calcium binding in dystrophic mdx muscle

2002 ◽  
Vol 92 (2) ◽  
pp. 435-445 ◽  
Author(s):  
Kevin Culligan ◽  
Niamh Banville ◽  
Paul Dowling ◽  
Kay Ohlendieck
Keyword(s):  
Skeletal Muscle ◽  
Sarcoplasmic Reticulum ◽  
Muscular Dystrophy ◽  
Calcium Binding ◽  
Functional Decline ◽  
Two Dimensional ◽  
Drastic Reduction ◽  
Dystrophic Muscle ◽  
One Dimensional ◽  
Blotting Technique

Although the reduction in dystrophin-associated glycoproteins is the primary pathophysiological consequence of the deficiency in dystrophin, little is known about the secondary abnormalities leading to x-linked muscular dystrophy. As abnormal Ca2+ handling may be involved in myonecrosis, we investigated the fate of key Ca2+ regulatory membrane proteins in dystrophic mdx skeletal muscle membranes. Whereas the expression of the ryanodine receptor, the dihydropyridine receptor, the Ca2+-ATPase, and calsequestrin was not affected, a drastic decline in calsequestrin-like proteins of 150–220 kDa was observed in dystrophic microsomes using one-dimensional immunoblotting, two-dimensional immunoblotting with isoelectric focusing, diagonal two-dimensional blotting technique, and immunoprecipitation. In analogy, overall Ca2+ binding was reduced in the sarcoplasmic reticulum of dystrophic muscle. The reduction in Ca2+ binding proteins might be directly involved in triggering impaired Ca2+ sequestration within the lumen of the sarcoplasmic reticulum. Thus disturbed sarcolemmal Ca2+ fluxes seem to influence overall Ca2+homeostasis, resulting in distinct changes in the expression profile of a subset of Ca2+ handling proteins, which might be an important factor in the progressive functional decline of dystrophic muscle fibers.

Differential protein input in the maternal diet alters the skeletal muscle transcriptome in fetal sheep

2020 ◽  
Vol 31 (9-12) ◽  
pp. 309-324
Author(s):  
Md Mahmodul Hasan Sohel ◽  
Bilal Akyuz ◽  
Yusuf Konca ◽  
Korhan Arslan ◽  
Kutlay Gurbulak ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Maternal Diet ◽  
Fetal Sheep ◽  
Differential Protein ◽  
Skeletal Muscle Transcriptome

scholarly journals Vibration mechanosignals superimposed to resistive exercise result in baseline skeletal muscle transcriptome profiles following chronic disuse in bed rest

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Michele Salanova ◽  
Guido Gambara ◽  
Manuela Moriggi ◽  
Michele Vasso ◽  
Ute Ungethuem ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Bed Rest ◽  
Resistive Exercise ◽  
Skeletal Muscle Transcriptome

Skeletal muscle transcriptome profiles related to different training intensities and detraining in Standardbred horses: A search for overtraining biomarkers

2013 ◽  
Vol 197 (3) ◽  
pp. 717-723 ◽  
Author(s):  
Marinus F.W. te Pas ◽  
Inge D. Wijnberg ◽  
Arend J.W. Hoekman ◽  
Ellen de Graaf-Roelfsema ◽  
Hans A. Keizer ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Skeletal Muscle Transcriptome

Low Skeletal Muscle Mass and Risk of Functional Decline in Elderly Community-Dwelling Women: The Prospective EPIDOS Study

2013 ◽  
Vol 14 (5) ◽  
pp. 352-357 ◽  
Author(s):  
Isabelle Amigues ◽  
Anne-Marie Schott ◽  
Mohamed Amine ◽  
Bénedicte Gelas-Dore ◽  
Kalaivani Veerabudun ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Functional Decline ◽  
Community Dwelling

129 Maternal plane of nutrition during mid-gestation affects the skeletal muscle transcriptome in beef cattle progeny

2017 ◽  
Vol 95 (suppl_4) ◽  
pp. 63-64
Author(s):  
J. C. McCann ◽  
T. B. Wilson ◽  
L. L. Guan ◽  
D. W. Shike ◽  
J. J. Loor
Keyword(s):  
Skeletal Muscle ◽  
Beef Cattle ◽  
Skeletal Muscle Transcriptome

scholarly journals The Human Skeletal Muscle Transcriptome in Response to Oral Shilajit Supplementation

2016 ◽  
Vol 19 (7) ◽  
pp. 701-709 ◽  
Author(s):  
Amitava Das ◽  
Soma Datta ◽  
Brian Rhea ◽  
Mithun Sinha ◽  
Muruganandam Veeraragavan ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Human Skeletal Muscle ◽  
Skeletal Muscle Transcriptome
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