A Low Frequency Genetic Variant in the Hepatic Glucokinase Gene is Associated with Type 2 Diabetes and Insulin Resistance in Chinese Population

Diabetes ◽  
2020 ◽  
pp. db200564
Author(s):  
Yumin Ma ◽  
Yingying Luo ◽  
Siqian Gong ◽  
Xianghai Zhou ◽  
Yufeng Li ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Chinese Population ◽  
Genetic Variant ◽  
Low Frequency ◽  
Glucokinase Gene

scholarly journals A Low Frequency Genetic Variant in the Hepatic Glucokinase Gene is Associated with Type 2 Diabetes and Insulin Resistance in Chinese Population

2020 ◽  
Author(s):  
Ada Admin ◽  
Yumin Ma ◽  
Yingying Luo ◽  
Siqian Gong ◽  
Xianghai Zhou ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Chinese Population ◽  
Cell Function ◽  
Low Frequency ◽  
Pooled Analysis ◽  
Cluster Sampling ◽  
Model Assessment ◽  
Two Samples

<a>Glucokinase (GCK) regulates insulin secretion and hepatic glucose metabolism, its inactivating variants could cause diabetes. We aimed to evaluate the association of a low-frequency variant of GCK (rs13306393) with type 2 diabetes (T2DM), prediabetes or both (IGR) in Chinese population. An association study was firstly conducted in a random cluster sampling population (Samples 1, 537 T2DM, 768 prediabetes and 1912 controls), then another independent Samples 2 (3896 T2DM, 2301 prediabetes and 868 controls) was used to confirm the findings in Samples 1. A-allele of rs13306393 was associated with T2DM [OR 3.08 (95%CI 1.77-5.36), p=0.00007] in Samples 1. Rs13306393 was also associated with prediabetes [OR 1.67 (95%CI 1.05-2.65), p=0.03] in Samples 2. In pooled analysis of two samples, A-allele increased the risk of T2DM [OR1.57 (95%CI 1.15-2.15), p=0.005], prediabetes [OR 1.83 (95%CI 1.33-2.54), p=0.0003) or IGR [OR 1.68 (95% CI 1.26-2.25), p=0.0004], insulin resistance estimated by homeostasis model assessment (beta=0.043, p=0.001), HbA1c (beta=0.029, P=0.029) and urinary albumin excretion (beta=0.033, p=0.025) irrespective of age, gender and BMI. Thus, the Chinese specific low-frequency variant increased the risk of T2DM through reducing insulin sensitivity rather than islet beta cell function, which should be considered in clinical use of GCK activators in the future.</a>

scholarly journals A Low Frequency Genetic Variant in the Hepatic Glucokinase Gene is Associated with Type 2 Diabetes and Insulin Resistance in Chinese Population

2020 ◽  
Author(s):  
Ada Admin ◽  
Yumin Ma ◽  
Yingying Luo ◽  
Siqian Gong ◽  
Xianghai Zhou ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Chinese Population ◽  
Cell Function ◽  
Low Frequency ◽  
Pooled Analysis ◽  
Cluster Sampling ◽  
Model Assessment ◽  
Two Samples

<a>Glucokinase (GCK) regulates insulin secretion and hepatic glucose metabolism, its inactivating variants could cause diabetes. We aimed to evaluate the association of a low-frequency variant of GCK (rs13306393) with type 2 diabetes (T2DM), prediabetes or both (IGR) in Chinese population. An association study was firstly conducted in a random cluster sampling population (Samples 1, 537 T2DM, 768 prediabetes and 1912 controls), then another independent Samples 2 (3896 T2DM, 2301 prediabetes and 868 controls) was used to confirm the findings in Samples 1. A-allele of rs13306393 was associated with T2DM [OR 3.08 (95%CI 1.77-5.36), p=0.00007] in Samples 1. Rs13306393 was also associated with prediabetes [OR 1.67 (95%CI 1.05-2.65), p=0.03] in Samples 2. In pooled analysis of two samples, A-allele increased the risk of T2DM [OR1.57 (95%CI 1.15-2.15), p=0.005], prediabetes [OR 1.83 (95%CI 1.33-2.54), p=0.0003) or IGR [OR 1.68 (95% CI 1.26-2.25), p=0.0004], insulin resistance estimated by homeostasis model assessment (beta=0.043, p=0.001), HbA1c (beta=0.029, P=0.029) and urinary albumin excretion (beta=0.033, p=0.025) irrespective of age, gender and BMI. Thus, the Chinese specific low-frequency variant increased the risk of T2DM through reducing insulin sensitivity rather than islet beta cell function, which should be considered in clinical use of GCK activators in the future.</a>

Association of ARHGEF11 R1467H polymorphism with risk for type 2 diabetes mellitus and insulin resistance in Chinese population

2011 ◽  
Vol 38 (4) ◽  
pp. 2499-2505 ◽  
Author(s):  
Jing Liu ◽  
Xiaohui Chen ◽  
Qian Guo ◽  
Xiaoqin Ma ◽  
Junqiang Zhang ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Chinese Population

scholarly journals Association of Serum Ferritin and Inflammatory Biomarkers with Insulin Resistance in Chinese Type 2 Diabetes Mellitus Patients

2020 ◽  
Vol 1 (7) ◽  
pp. 363-371
Author(s):  
Pratiksha Paudel ◽  
Shitian Zhang ◽  
Bei Guo ◽  
Alisha Pannu ◽  
Gajarishiyan Rasalingam ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Serum Ferritin ◽  
Chinese Population ◽  
Inflammatory Biomarkers ◽  
Model Assessment ◽  
Tnf Α

Objective: Obesity-induced Insulin Resistance (IR) is one of the main causes of Type 2 Diabetes Mellitus (T2DM) and accompanies the progression of T2DM. Serum Ferritin has been shown to be associated with IR. Inflammation is also suggested to be involved in IR and pancreatic β-cell dysfunction. However, there is lack of enough evidence concerning the interrelationship between serum Ferritin, inflammation, and IR in the Chinese population with T2DM. In this study, the relationships between serum Ferritin and inflammatory biomarkers with IR in Chinese population were investigated. Methods: This cross-sectional study was conducted with 207 Chinese participants, aged 40-60 years in Tianjin, China. Serum Ferritin, transferrin, and folate were measured by immuno-assay analyzer. The levels of TNF-α, IL-1β, and IL-6 were detected by ELISA. IR was evaluated by Homeostasis model assessment (HOMA) of IR. Correlations were examined by regression analyses. Results: Serum Ferritin level was higher in non-diabetic obese and diabetic group than the non-diabetic lean group. The levels of TNF-α and CRP were significantly higher in the diabetic obese group than non-diabetic and diabetic lean subjects. Serum Ferritin, TNF-α, and CRP were all correlated with BMI. TNF-α correlated with IR and FPI. TNF-α, IL-6, IL-1β, and CRP were all correlated with FPG and HbA1c. Conclusion: In Chinese population, IR had a significant association with TNF-α but not with serum Ferritin. Serum Ferritin, TNF-α, and CRP were all correlated with BMI. Inflammation and glucose metabolism factors (FPG, HbA1c) showed a strong correlation with each other as well as with adiposity.

Association of P213S polymorphism of the L-selectin gene with type 2 diabetes and insulin resistance in Chinese population

Gene ◽  
2012 ◽  
Vol 509 (2) ◽  
pp. 286-290
Author(s):  
Jing Liu ◽  
Ju-xiang Liu ◽  
San-ni Xu ◽  
Jin-xing Quan ◽  
Li-min Tian ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Chinese Population

scholarly journals Erratum: Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia

2009 ◽  
Vol 41 (10) ◽  
pp. 1156-1156 ◽  
Author(s):  
Johan Rung ◽  
Stéphane Cauchi ◽  
Anders Albrechtsen ◽  
Lishuang Shen ◽  
Ghislain Rocheleau ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Genetic Variant
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