2276-PUB: A Palatable, Novel Whey Protein Shot Attenuates Postprandial Glycemia in Lean and Centrally Obese Adult Males

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2276-PUB
Author(s):  
KIERAN SMITH ◽  
GUY S. TAYLOR ◽  
NDUKA OKWOSE ◽  
DEAN M. ALLERTON ◽  
LISE HOEJ BRUNSGAARD ◽  
...  
Keyword(s):  
Whey Protein ◽  
Obese Adult ◽  
Adult Males ◽  
Postprandial Glycemia

scholarly journals The Postprandial Glycaemic and Hormonal Responses Following the Ingestion of a Novel, Ready-to-Drink Shot Containing a Low Dose of Whey Protein in Centrally Obese and Lean Adult Males: A Randomised Controlled Trial

2021 ◽  
Vol 12 ◽  
Author(s):  
Kieran Smith ◽  
Guy S. Taylor ◽  
Dean M. Allerton ◽  
Lise Hoej Brunsgaard ◽  
Kelly A. Bowden Davies ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Whey Protein ◽  
Controlled Trial ◽  
Area Under The Curve ◽  
Fold Increase ◽  
Central Adiposity ◽  
Adult Males ◽  
Clinical Trial Registration ◽  
Insulin Resistant ◽  
Randomised Controlled

PurposeElevated postprandial glycaemia [PPG] increases the risk of cardiometabolic complications in insulin-resistant, centrally obese individuals. Therefore, strategies that improve PPG are of importance for this population. Consuming large doses of whey protein [WP] before meals reduces PPG by delaying gastric emptying and stimulating the secretion of the incretin peptides, glucose-dependent insulinotropic polypeptide [GIP] and glucagon-like peptide 1 [GLP-1]. It is unclear if these effects are observed after smaller amounts of WP and what impact central adiposity has on these gastrointestinal processes.MethodsIn a randomised-crossover design, 12 lean and 12 centrally obese adult males performed two 240 min mixed-meal tests, ~5–10 d apart. After an overnight fast, participants consumed a novel, ready-to-drink WP shot (15 g) or volume-matched water (100 ml; PLA) 10 min before a mixed-nutrient meal. Gastric emptying was estimated by oral acetaminophen absorbance. Interval blood samples were collected to measure glucose, insulin, GIP, GLP-1, and acetaminophen.ResultsWP reduced PPG area under the curve [AUC0–60] by 13 and 18.2% in the centrally obese and lean cohorts, respectively (both p <0.001). In both groups, the reduction in PPG was accompanied by a two-three-fold increase in GLP-1 and delayed gastric emptying. Despite similar GLP-1 responses during PLA, GLP-1 secretion during the WP trial was ~27% lower in centrally obese individuals compared to lean (p = 0.001). In lean participants, WP increased the GLP-1ACTIVE/TOTAL ratio comparative to PLA (p = 0.004), indicative of reduced GLP-1 degradation. Conversely, no treatment effects for GLP-1ACTIVE/TOTAL were seen in obese subjects.ConclusionPre-meal ingestion of a novel, ready-to-drink WP shot containing just 15 g of dietary protein reduced PPG in lean and centrally obese males. However, an attenuated GLP-1 response to mealtime WP and increased incretin degradation might impact the efficacy of nutritional strategies utilising the actions of GLP-1 to regulate PPG in centrally obese populations. Whether these defects are caused by an individual’s insulin resistance, their obese state, or other obesity-related ailments needs further investigation.Clinical Trial RegistrationISRCTN.com, identifier [ISRCTN95281775]. https://www.isrctn.com/.

Title: Differentiating the effects of whey protein and guar gum preloads on postprandial glycemia in type 2 diabetes

2019 ◽  
Vol 38 (6) ◽  
pp. 2827-2832 ◽  
Author(s):  
Linda E. Watson ◽  
Liza K. Phillips ◽  
Tongzhi Wu ◽  
Michelle J. Bound ◽  
Helen Checklin ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Whey Protein ◽  
Guar Gum ◽  
Postprandial Glycemia
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