226-LB: HOMA-ß and ß-Cell Activity in Early and Late Phase during an OGTT Are Independent Risk Factors of Type 2 Diabetes in Japanese Americans

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 226-LB
Author(s):  
TAKU SHIMOJO ◽  
CHIHAYA IZUMI ◽  
KYOKO K. SATO ◽  
DONNA L. LEONETTI ◽  
STEVEN E. KAHN ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Late Phase ◽  
Cell Activity ◽  
Japanese Americans ◽  
Independent Risk Factors

scholarly journals Urinary NGAL and RBP Are Biomarkers of Normoalbuminuric Renal Insufficiency in Type 2 Diabetes Mellitus

2019 ◽  
Vol 2019 ◽  
pp. 1-11 ◽  
Author(s):  
Aimei Li ◽  
Bin Yi ◽  
Yan Liu ◽  
Jianwen Wang ◽  
Qing Dai ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Renal Insufficiency ◽  
Urinary Ngal ◽  
Independent Risk Factors ◽  
Pai 1 ◽  
E Cadherin

Objectives. As a screening index of diabetic kidney disease (DKD), urinary albumin/creatine ratio (UACR) is commonly used. However, approximately 23.3%-56.6% of DKD patients with estimated glomerular filtration rate eGFR<60 ml/min per 1.73 m2 are normoalbuminuric. Thus, urinary biomarkers of nonalbuminuric renal insufficiency in type 2 diabetes mellitus (T2DM) patients are urgently needed. Methods. This cross-sectional study enrolled 209 T2DM patients with normoalbuminuria whose diabetes duration was more than 5 years. The patients were classified into two groups, NO-CKD (eGFR≥60 ml/min per 1.73 m2, n=165) and NA-DKD (eGFR<60 ml/min per 1.73 m2, n=44). Levels of urinary neutrophil gelatinase-associated lipocalin (NGAL), retinol-binding protein (RBP), plasminogen activator inhibitor-1 (PAI-1), vascular cell adhesion molecule-1 (VCAM-1), and E-cadherin were detected, and their correlations with eGFR, plasma TNF-α, IL-6, endothelin-1 (ET-1), and 8-hydroxydeoxyguanosine (8-OHdG) were assessed. Results. Among patients with renal insufficiency, 26.0% was normoalbuminuric. Compared to the NO-CKD group, the NA-DKD group was older with lower hemoglobin (HB) levels and higher systolic blood pressure (SBP), plasma TNF-α, IL-6, and 8-OHdG levels. Logistic regression analysis suggested that age, TNF-α, and 8-OHdG were independent risk factors for nonalbuminuric renal insufficiency. Compared to the NO-CKD group, the NA-DKD group exhibited significant increases in urinary NGAL and RBP levels but not PAI-1, VCAM-1, and E-cadherin. Urinary NGAL and RBP both correlated negatively with eGFR and positively with plasma IL-6 and 8-OHdG. Multiple linear regression indicated NGAL (β=−0.287, p=0.008) and RBP (β=−44.545, p<0.001) were independently correlated with eGFR. Conclusion. Age, plasma TNF-α, and 8-OHdG are independent risk factors for renal insufficiency in T2DM patients with normoalbuminuria. Urinary NGAL and RBP can serve as noninvasive biomarkers of normoalbuminuric renal insufficiency in T2DM.

scholarly journals Risk factors for type 2 diabetes: Lessons learned from Japanese Americans in Seattle

2012 ◽  
Vol 3 (3) ◽  
pp. 212-224 ◽  
Author(s):  
Wilfred Y Fujimoto ◽  
Edward J Boyko ◽  
Tomoshige Hayashi ◽  
Steven E Kahn ◽  
Donna L Leonetti ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Lessons Learned ◽  
Japanese Americans

1612-P: Insulinogenic Index and HOMA-ß Are Independent Risk Factors for Future Type 2 Diabetes

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1612-P
Author(s):  
KYOKO K. SATO ◽  
TOMOSHIGE HAYASHI ◽  
SHINICHIRO UEHARA ◽  
YUKIKO ONISHI ◽  
DONNA L. LEONETTI ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Insulinogenic Index ◽  
Independent Risk Factors

scholarly journals Clinical Significance of Hemostatic Parameters in the Prediction for Type 2 Diabetes Mellitus and Diabetic Nephropathy

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Lianlian Pan ◽  
Yali Ye ◽  
Mingyi Wo ◽  
Danni Bao ◽  
Fengjiao Zhu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Risk Factors ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy ◽  
High Sensitivity ◽  
Area Under Roc Curve ◽  
Independent Risk Factors ◽  
Low Sensitivity

It would be important to predict type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN). This study was aimed at evaluating the predicting significance of hemostatic parameters for T2DM and DN. Plasma coagulation and hematologic parameters before treatment were measured in 297 T2DM patients. The risk factors and their predicting power were evaluated. T2DM patients without complications exhibited significantly different activated partial thromboplastin time (aPTT), platelet (PLT), and D-dimer (D-D) levels compared with controls (P<0.01). Fibrinogen (FIB), PLT, and D-D increased in DN patients compared with those without complications (P<0.001). Both aPTT and PLT were the independent risk factors for T2DM (OR: 1.320 and 1.211, P<0.01, resp.), and FIB and PLT were the independent risk factors for DN (OR: 1.611 and 1.194, P<0.01, resp.). The area under ROC curve (AUC) of aPTT and PLT was 0.592 and 0.647, respectively, with low sensitivity in predicting T2DM. AUC of FIB was 0.874 with high sensitivity (85%) and specificity (76%) for DN, and that of PLT was 0.564, with sensitivity (60%) and specificity (89%) based on the cutoff values of 3.15 g/L and 245 × 109/L, respectively. This study suggests that hemostatic parameters have a low predicting value for T2DM, whereas fibrinogen is a powerful predictor for DN.

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