141-OR: Regulation of Mitochondrial Dynamics in Brown Adipocytes by the Endoplasmic Reticulum-Associated Degradation

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 141-OR
Author(s):  
ZHANGSEN ZHOU ◽  
MAURICIO TORRES ◽  
LING QI
Keyword(s):  
Endoplasmic Reticulum ◽  
Mitochondrial Dynamics ◽  
Brown Adipocytes ◽  
Endoplasmic Reticulum Associated Degradation

scholarly journals Endoplasmic reticulum–associated degradation regulates mitochondrial dynamics in brown adipocytes

Science ◽  
2020 ◽  
Vol 368 (6486) ◽  
pp. 54-60 ◽  
Author(s):  
Zhangsen Zhou ◽  
Mauricio Torres ◽  
Haibo Sha ◽  
Christopher J. Halbrook ◽  
Françoise Van den Bergh ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Mitochondrial Dynamics ◽  
Three Dimensional ◽  
Sigma Receptor ◽  
High Resolution Imaging ◽  
Brown Adipocytes ◽  
Physiological Importance ◽  
Endoplasmic Reticulum Associated Degradation ◽  
Cold Sensitive ◽  
Resolution Imaging

The endoplasmic reticulum (ER) engages mitochondria at specialized ER domains known as mitochondria-associated membranes (MAMs). Here, we used three-dimensional high-resolution imaging to investigate the formation of pleomorphic “megamitochondria” with altered MAMs in brown adipocytes lacking the Sel1L-Hrd1 protein complex of ER-associated protein degradation (ERAD). Mice with ERAD deficiency in brown adipocytes were cold sensitive and exhibited mitochondrial dysfunction. ERAD deficiency affected ER-mitochondria contacts and mitochondrial dynamics, at least in part, by regulating the turnover of the MAM protein, sigma receptor 1 (SigmaR1). Thus, our study provides molecular insights into ER-mitochondrial cross-talk and expands our understanding of the physiological importance of Sel1L-Hrd1 ERAD.

scholarly journals Unraveling the function of Arabidopsis thaliana OS9 in the endoplasmic reticulum-associated degradation of glycoproteins

2012 ◽  
Vol 79 (1-2) ◽  
pp. 21-33 ◽  
Author(s):  
Silvia Hüttner ◽  
Christiane Veit ◽  
Jennifer Schoberer ◽  
Josephine Grass ◽  
Richard Strasser
Keyword(s):  
Arabidopsis Thaliana ◽  
Endoplasmic Reticulum ◽  
Endoplasmic Reticulum Associated Degradation
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