The Effect of Two Isocaloric and Energy-Matched Plant-Based and Processed-Meat Meals on Glucose Metabolism, Gastrointestinal Hormones, and Satiety in Subjects with T2D, Obese Subjects, and Healthy Controls—A Randomized Crossover Study

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 784-P ◽  
Author(s):  
MARTA KLEMENTOVA ◽  
LENKA BELINOVA ◽  
MARTIN HALUZIK ◽  
RENATA PAVLOVICOVA ◽  
MARTIN HILL ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Crossover Study ◽  
Gastrointestinal Hormones ◽  
Processed Meat ◽  
Healthy Controls ◽  
Obese Subjects ◽  
Randomized Crossover Study

scholarly journals Black pepper-based beverage induced appetite-suppressing effects without altering postprandial glycaemia, gut and thyroid hormones or gastrointestinal well-being: a randomized crossover study in healthy subjects

2018 ◽  
Vol 9 (5) ◽  
pp. 2774-2786 ◽  
Author(s):  
Yoghatama Cindya Zanzer ◽  
Merichel Plaza ◽  
Anestis Dougkas ◽  
Charlotta Turner ◽  
Elin Östman
Keyword(s):  
Glucose Metabolism ◽  
Thyroid Hormones ◽  
Crossover Study ◽  
Healthy Subjects ◽  
Clinical Investigation ◽  
Well Being ◽  
Black Pepper ◽  
Pleiotropic Effects ◽  
Energy Regulation ◽  
Randomized Crossover Study

Pleiotropic effects of spices on health, particularly on glucose metabolism and energy regulation, deserve further clinical investigation into their efficacy.

scholarly journals Effects of branched-chain amino acids on glucose metabolism in obese, prediabetic men and women: a randomized, crossover study

2019 ◽  
Vol 109 (6) ◽  
pp. 1569-1577 ◽  
Author(s):  
Shih-Lung Woo ◽  
Jieping Yang ◽  
Mark Hsu ◽  
Alicia Yang ◽  
Lijun Zhang ◽  
...  
Keyword(s):  
Amino Acids ◽  
Glucose Metabolism ◽  
Crossover Study ◽  
Plasma Concentrations ◽  
Area Under The Curve ◽  
Branched Chain Amino Acids ◽  
Oral Glucose ◽  
Monocyte Chemoattractant Protein 1 ◽  
Branched Chain ◽  
Randomized Crossover Study

ABSTRACT Background Recent studies have shown that circulating branched-chain amino acids (BCAAs) are elevated in obese, insulin-resistant individuals. However, it is not known if supplementation of additional BCAAs will further impair glucose metabolism. Objectives The aim of this pilot study was to determine the effects of BCAA supplementation on glucose metabolism in obese, prediabetic individuals. Methods This is a randomized crossover study involving 12 obese individuals with prediabetes. Participants were randomly assigned to receive a daily supplement containing either 20 g BCAA or protein low in BCAAs for 4 wk with a 2-wk washout in between. At each visit, an oral-glucose-tolerance test (OGTT) was performed. Collected blood samples were used to measure glucose, insulin, and insulin resistance–associated biomarkers. Results BCAA supplementation tended to decrease the plasma glucose area under the curve (AUC) measured by the OGTT (AUC percentage change from supplementation baseline, BCAA: −3.3% ± 3%; low-BCAA: 10.0% ± 6%; P = 0.08). However, BCAA supplementation did not affect plasma insulin during OGTT challenge (BCAA: −3.9% ± 8%; low-BCAA: 14.8% ± 10%; P = 0.28). The plasma concentrations of nerve growth factor (BCAA: 4.0 ± 1 pg/mL; low-BCAA: 5.7 ± 1 pg/mL; P = 0.01) and monocyte chemoattractant protein-1 (BCAA: −0.4% ± 9%; low-BCAA: 29.0% ± 18%; P = 0.02) were significantly lowered by BCAA supplementation compared to low-BCAA control. Plasma interleukin 1β was significantly elevated by BCAA supplementation (BCAA: 231.4% ± 187%; low-BCAA: 20.6% ± 33%; P = 0.05). BCAA supplementation did not affect the circulating concentrations of the BCAAs leucine (BCAA: 9.0% ± 12%; low-BCAA: 9.2% ± 11%), valine (BCAA: 9.1% ± 11%; low-BCAA: 12.0% ± 13%), or isoleucine (BCAA: 2.5% ± 11%; low-BCAA: 7.3% ± 11%). Conclusions Our data suggest that BCAA supplementation did not impair glucose metabolism in obese, prediabetic subjects. Further studies are needed to confirm the results seen in the present study. This study was registered at clinicaltrials.gov as NCT03715010.

755-P: A Plant-Based Meal Stimulates Incretin and Insulin Secretion More than an Energy- and Macronutrient-Matched Standard Meal in Type 2 Diabetes: A Randomized Crossover Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 755-P
Author(s):  
HANA KAHLEOVA ◽  
ANDREA TURA ◽  
MARTA KLEMENTOVA ◽  
LENKA BELINOVA ◽  
MARTIN HALUZIK ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Crossover Study ◽  
Standard Meal ◽  
Randomized Crossover Study
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