Inhibitory Effects of Intranasal Insulin Administration on Fat Oxidation during Exercise Are Diminished in Overweight Young Individuals

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 736-P
Author(s):  
HISAYO YOKOYAMA ◽  
RYOSUKE TAKEDA ◽  
ERIKO KAWAI ◽  
AKEMI OTA ◽  
EMIKO MORITA ◽  
...  
Keyword(s):  
Fat Oxidation ◽  
Insulin Administration ◽  
Intranasal Insulin ◽  
Inhibitory Effects

Acute, but not long-term intranasal insulin administration elevates blood pressure

2004 ◽  
Vol 112 (08) ◽  
Author(s):  
C Benedict ◽  
C Dodt ◽  
M Hallschmid ◽  
HL Fehm ◽  
J Born ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Insulin Administration ◽  
Intranasal Insulin

scholarly journals Inhibitory Effects of Intranasal Administration of Insulin on Fat Oxidation during Exercise Are Diminished in Young Overweight Individuals

2018 ◽  
Vol 7 (10) ◽  
pp. 308 ◽  
Author(s):  
Hisayo Yokoyama ◽  
Ryosuke Takeda ◽  
Eriko Kawai ◽  
Akemi Ota ◽  
Emiko Morita ◽  
...  
Keyword(s):  
Intranasal Administration ◽  
Fat Oxidation ◽  
Inhibitory Effect ◽  
Normal Weight ◽  
Inhibitory Effects ◽  
Glucose Levels ◽  
Graded Exercise ◽  
High Insulin ◽  
Exercise Induced ◽  
The Brain

It remains unknown whether the high insulin (INS) levels in the brain affect fat oxidation during exercise. We examined the effects of the intranasal administration of INS, which increases the INS concentration in the cerebrospinal fluid when peripheral effects are lacking, on the maximum fat oxidation rate (maxFOR) and its intensity (FATmax) during exercise in 15 young normal-weight (N group) and eight young overweight (O group) individuals. On two separate days, either INS or placebo (PL) was randomly administered intranasally before a graded exercise test. Indirect calorimetry was used to assess maxFOR and FATmax during exercise. Blood INS and glucose levels did not change after INS administration. In the N group, maxFOR and FATmax were significantly smaller in the INS trial than in the PL trial. MaxFOR was significantly smaller in the O group than in the N group and was not influenced by INS administration. Exercise-induced elevation in blood epinephrine levels tended to be reduced by INS administration only in the N group. Intranasal INS administration reduces fat oxidation during exercise without any peripheral effects, possibly by suppressing sympathetic nerve activity. This inhibitory effect is diminished in overweight subjects, suggesting that cerebral insulin effects are attenuated in this population.

scholarly journals Intranasal insulin administration does not modulate incretin secretion, gastric emptying, and appetite in healthy young adults

2016 ◽  
Vol 3 (3) ◽  
pp. 682-687
Author(s):  
Yoshikazu Hirasawa ◽  
Hisayo Yokoyama ◽  
Nooshin Naghavi ◽  
Yoshihiro Yamashina ◽  
Ryosuke Takeda ◽  
...  
Keyword(s):  
Young Adults ◽  
Gastric Emptying ◽  
Insulin Administration ◽  
Intranasal Insulin ◽  
Incretin Secretion
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