Extreme Hyperglycemia Causes Vascular Hypoperfusion at Optic Nerve Head in Diabetic Patients (DM)

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 602-P
Author(s):  
TAKAKO MITSUMATSU ◽  
FUMIHIKO YAGI ◽  
YUKO KONDO ◽  
AYAKO ANRAKU ◽  
SUMIE OKAHATA ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Diabetic Patients ◽  
Vascular Hypoperfusion

scholarly journals Quantification of Microvascular Density of the Optic Nerve Head in Diabetic Retinopathy Using Optical Coherence Tomographic Angiography

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Jianfeng Huang ◽  
Bodi Zheng ◽  
Yingyi Lu ◽  
Xiaoya Gu ◽  
Hong Dai ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Roc Curve ◽  
Mixed Model ◽  
Diabetic Patients ◽  
Optical Coherence ◽  
Binary Logistic Regression Model ◽  
Fiber Layer ◽  
Tomographic Angiography

Aims. To quantify the capillary density of the optic nerve head in healthy control eyes and different stages of diabetic retinopathy (DR) eyes and identify the parameters to detect eyes with or without DR using optical coherence tomographic angiography (OCTA). Methods. In this cross-sectional study, 211 eyes of 121 participants with type 2 diabetes with different stages of DR or without DR and 73 eyes of 38 healthy age-matched controls were imaged by OCTA. Radial peripapillary capillary (RPC) plexus density and retinal nerve fiber layer (RNFL) thickness were examined. The mixed model binary logistic regression model was used to identify the parameters to detect eyes with or without DR. The area under the receiver operating characteristic (ROC) curve was calculated. Results. RPC density decreased significantly in diabetic patients without DR compared with the healthy controls, and it was negatively correlated with the severity of DR (P<0.01). RPC density was a significant parameter to distinguish diabetic eyes with or without DR (P<0.01). The area under the ROC curve was 0.743. Conclusions. Quantification of RPC density by OCTA provides evidence of microvascular changes in the optic nerve in diabetic patients. RPC density can serve as a possible biomarker in detecting eyes with DR. Larger cohort studies need to support this statement.

Synchronous evaluation of early neurovascular changes in macula and optic nerve head in early diabetic retinopathy using combined optical coherence tomography angiography parameters

2019 ◽  
Author(s):  
Xin Wen ◽  
Zijing Li ◽  
Jiaqi Liang ◽  
Jianhui Xiao ◽  
Yichi Zhang ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Diabetic Retinopathy ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Optical Coherence Tomography Angiography ◽  
Diabetic Patients ◽  
Healthy Controls ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Type 2 Diabetic Patients

Abstract Background This study aim to evaluate neurovascular changes in both macula and optic nerve head (ONH) in early stages of diabetic retinopathy (DR) using combined quantitative optical coherence tomography angiography (OCTA) parameters.Methods We studied 194 right eyes from 64 type 2 diabetic patients without DR (DM), 64 diabetic patients with nonproliferative diabetic retinopathy (NPDR) and 64 age-matched healthy controls. OCTA parameters were analyzed using binary logistic regression models and receiver operating characteristic (ROC) curves.Results There was significant reduction of vessel density (VD) in both macula and ONH comparing DM patients with and without NPDR to controls. The area under the curve (AUC) of the ROC curve for NPDR versus control was 0.963 ( p <0.001), with sensitivity of 93.8% and specificity of 90.6%. The ROC curves for NPDR patients versus NoDR patients (including DM and control groups) exhibited an AUC of 0.923 ( p <0.001), with sensitivity of 90.6% and specificity of 82.8%. The thickness of the retinal nerve fiber layer (RNFL) in both macula and ONH was not significantly different among these three groups.Conclusions VD in both macula and ONH was simultaneously decreased prior to RNFL thinning in DM patients through the course proceeding from preclinical DR to NPDR. Combined analysis of macula and ONH parameters was an comprehensive and accurate OCTA metric to distinguish NPDR patients from healthy controls and DM patients without DR.

scholarly journals Choroidal microvasculature dropout is spatially associated with optic nerve head microvasculature loss in open-angle glaucoma

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Min Kyung Song ◽  
Joong Won Shin ◽  
Jin Yeong Lee ◽  
Ji Wook Hong ◽  
Michael S. Kook
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Optical Coherence Tomography Angiography ◽  
Open Angle Glaucoma ◽  
Spatial Relationship ◽  
Vascular Supply ◽  
Open Angle ◽  
Regression Analyses ◽  
Angular Extent ◽  
Choroidal Vessels

AbstractThe presence of parapapillary choroidal microvasculature dropout (CMvD) may affect optic nerve head (ONH) perfusion in glaucoma patients, since parapapillary choroidal vessels provide vascular supply to the neighboring ONH. However, it remains to be determined whether the presence of parapapillary CMvD is associated with diminished perfusion in the nearby ONH. The present study investigated the spatial relationship between CMvD and ONH vessel density (ONH-VD) loss in open-angle glaucoma (OAG) eyes using optical coherence tomography angiography (OCT-A). This study included 48 OAG eyes with a single localized CMvD confined to the inferotemporal parapapillary sector and 48 OAG eyes without CMvD, matched for demographic and ocular characteristics. Global and regional ONH-VD values were compared between eyes with and without CMvD. The relationships between ONH-VD outcomes and clinical variables were assessed. ONH-VDs at the inferotemporal ONH sectors corresponding to the CMvD location were significantly lower in eyes with compared to those without CMvD. Multivariable linear regression analyses indicated that a lower inferotemporal ONH-VD was independently associated with CMvD presence and a greater CMvD angular extent (both P < 0.05). The localized presence of parapapillary CMvD in OAG eyes is significantly associated with ONH-VD loss in the neighboring ONH location, with a spatial correlation.

scholarly journals Coloboma of the Optic Nerve Head in Benbal Tiger Kittens (Panthera tigris tigris)

1985 ◽  
Vol 26 (1) ◽  
pp. 136-139
Author(s):  
H. H. Dietz ◽  
E. Eriksen ◽  
O. A. Jensen
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Panthera Tigris ◽  
Panthera Tigris Tigris

scholarly journals Blue light blind-spot stimulation upregulates b-wave and pattern ERG activity in myopes

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ana Amorim-de-Sousa ◽  
Tim Schilling ◽  
Paulo Fernandes ◽  
Yeshwanth Seshadri ◽  
Hamed Bahmani ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Electrical Activity ◽  
Blue Light ◽  
Optic Nerve Head ◽  
Plexiform Layer ◽  
Pattern Electroretinogram ◽  
Blind Spot ◽  
Inner Plexiform Layer ◽  
Pattern Erg ◽  
Myopia Progression

AbstractUpregulation of retinal dopaminergic activity may be a target treatment for myopia progression. This study aimed to explore the viability of inducing changes in retinal electrical activity with short-wavelength light targeting melanopsin-expressing retinal ganglion cells (ipRGCs) passing through the optic nerve head. Fifteen healthy non-myopic or myopic young adults were recruited and underwent stimulation with blue light using a virtual reality headset device. Amplitudes and implicit times from photopic 3.0 b-wave and pattern electroretinogram (PERG) were measured at baseline and 10 and 20 min after stimulation. Relative changes were compared between non-myopes and myopes. The ERG b-wave amplitude was significantly larger 20 min after blind-spot stimulation compared to baseline (p < 0.001) and 10 min (p < 0.001) post-stimulation. PERG amplitude P50-N95 also showed a significant main effect for ‘Time after stimulation’ (p < 0.050). Implicit times showed no differences following blind-spot stimulation. PERG and b-wave changes after blind-spot stimulation were stronger in myopes than non-myopes. It is possible to induce significant changes in retinal electrical activity by stimulating ipRGCs axons at the optic nerve head with blue light. The results suggest that the changes in retinal electrical activity are located at the inner plexiform layer and are likely to involve the dopaminergic system.

scholarly journals Large-scale machine learning-based phenotyping significantly improves genomic discovery for optic nerve head morphology

2021 ◽  
Author(s):  
Babak Alipanahi ◽  
Farhad Hormozdiari ◽  
Babak Behsaz ◽  
Justin Cosentino ◽  
Zachary R. McCaw ◽  
...  
Keyword(s):  
Machine Learning ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Large Scale ◽  
Head Morphology

Blind Source Separation of Retinal Pulsatile Patterns in Optic Nerve Head Video-Recordings

2020 ◽  
pp. 1-1
Author(s):  
Ivana Labounkova ◽  
Rene Labounek ◽  
Igor Nestrasil ◽  
Jan Odstrcilik ◽  
Ralf P. Tornow ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Blind Source Separation ◽  
Optic Nerve Head ◽  
Source Separation ◽  
Video Recordings
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