Alterations in Histone Acetylation in Diabetic Painful Neuropathy

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 583-P
Author(s):  
MUNMUN CHATTOPADHYAY ◽  
VIKRAM THAKUR
Keyword(s):  
Histone Acetylation ◽  
Painful Neuropathy ◽  
Diabetic Painful Neuropathy

Role of Acupuncture in the Management of Diabetic Painful Neuropathy (Dpn): A Pilot Rct

2014 ◽  
Vol 32 (3) ◽  
pp. 242-249 ◽  
Author(s):  
Adam P Garrow ◽  
Mei Xing ◽  
Joanne Vere ◽  
Barbara Verrall ◽  
LiFen Wang ◽  
...  
Keyword(s):  
Lower Limb ◽  
Short Form ◽  
Pain Scale ◽  
Sham Acupuncture ◽  
Additional Treatment ◽  
Acupuncture Points ◽  
Painful Neuropathy ◽  
Diabetic Painful Neuropathy ◽  
Lower Limb Pain

Aims To examine the role of acupuncture in the treatment of diabetic painful neuropathy (DPN) using a single-blind, placebo-controlled RCT and to collect data that would be required in a future definitive study of the efficacy of acupuncture in DPN. Methods 45 patients were allocated to receive a 10-week course either of real (53%) or sham (47%) acupuncture. Five standardised acupuncture points on the lower limb of each leg were used in the study: LR3, KI3, SP6, SP10 and ST36. Outcome measures included the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) scale, lower limb pain (Visual Analogue Scale, VAS); Sleep Problem Scale (SPS); Measure Yourself Medical Outcome Profile (MYMOP); 36-item Short Form 36 Health Survey and resting blood pressure (BP). Results Over the 10-week treatment period, small improvements were seen in VAS −15 (−26 to −3.5), MYMOP −0.89 (−1.4 to −0.3), SPS −2.5 (−4.2 to −0.82) and resting diastolic BP −5.2 (−10.4 to −0.14) in the true acupuncture group. In contrast, there was little change in those receiving sham acupuncture. A moderate treatment effect in favour of active acupuncture was detected in MYMOP scores −0.66 (−0.96 to −0.35) but non-significant effect sizes in LANSS Pain Scale −0.37 (−2.2 to 1.4), resting diastolic BP −0.50 (−3.0 to 1.99) and the SPS −0.51 (−2.2 to 1.16). Conclusions We have demonstrated the practicality and feasibility of acupuncture as an additional treatment for people with DPN. The treatment was well tolerated with no appreciable side effects. Larger randomised trials are needed to confirm the clinical and cost-effectiveness of acupuncture in the treatment of DPN. Trial Registration Number ISRCTN number: 39740785.

scholarly journals Proteomics Analysis of the Spinal Dorsal Horn in Diabetic Painful Neuropathy Rats With Electroacupuncture Treatment

2021 ◽  
Vol 12 ◽  
Author(s):  
Xiangmei Yu ◽  
Xiaomei Chen ◽  
Weiting Liu ◽  
Menghong Jiang ◽  
Zhifu Wang ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Dorsal Horn ◽  
Spinal Dorsal Horn ◽  
Fasting Blood Glucose ◽  
Male Rats ◽  
Tandem Mass ◽  
Painful Neuropathy ◽  
Proteomics Analysis ◽  
Spinal Dorsal ◽  
Diabetic Painful Neuropathy

BackgroundClinical evidence demonstrates that electro-acupuncture (EA) of the Zu sanli (ST36) and Shen shu (BL23) acupoints is effective in relieving diabetic painful neuropathy (DPN); however, the underlying molecular mechanism requires further investigation, including the protein molecules associated with EA’s effects on DPN.MethodsSprague-Dawley adult male rats (n =36) were randomly assigned into control, DPN, and EA groups (n=12 each). After four weeks of EA treatment, response to mechanical pain and fasting blood glucose were analyzed. A tandem mass tag (TMT) labeling approach coupled with liquid chromatography with tandem mass spectrometry was used to identify potential biomarkers in the spinal dorsal horn. Further, proteomics analysis was used to quantify differentially expressed proteins (DEPs), and gene ontology, KEGG pathways, cluster, and string protein network interaction analyses conducted to explore the main protein targets of EA.ResultsCompared with the DPN model group, the mechanical pain threshold was significantly increased, while the fasting blood glucose levels were clearly decreased in EA group rats. Proteomics analysis was used to quantify 5393 proteins, and DEPs were chosen for further analyses, based on a threshold of 1.2-fold difference in expression level (P < 0.05) compared with control groups. Relative to the control group, 169 down-regulated and 474 up-regulated proteins were identified in the DPN group, while 107 and 328 proteins were up- and down-regulated in the EA treatment group compared with the DPN group. Bioinformatics analysis suggested that levels of proteins involved in oxidative stress injury regulation were dramatically altered during the EA effects on DPN.ConclusionsOur results provide the valuable protein biomarkers, which facilitates unique mechanistic insights into the DPN pathogenesis and EA analgesic, antioxidant stress and hypoglycemic effect.

Upregulation of NLRP3 via STAT3-dependent histone acetylation contributes to painful neuropathy induced by bortezomib

2018 ◽  
Vol 302 ◽  
pp. 104-111 ◽  
Author(s):  
Cui-Cui Liu ◽  
Zhu-Xi Huang ◽  
Xiao Li ◽  
Kai-Feng Shen ◽  
Meng Liu ◽  
...  
Keyword(s):  
Histone Acetylation ◽  
Painful Neuropathy

Single- Versus Multiple-Drug Pharmacotherapy in the Management of Diabetic Painful Neuropathy

2016 ◽  
Vol 30 (3) ◽  
pp. 184-194
Author(s):  
Kuan-Ling Kuo ◽  
Diana Brixner ◽  
Arthur G. Lipman ◽  
Michael Goodman ◽  
Man Hung ◽  
...  
Keyword(s):  
Multiple Drug ◽  
Painful Neuropathy ◽  
Diabetic Painful Neuropathy ◽  
Single Versus

scholarly journals Fibromyalgia and neuropathic pain - differences and similarities. A comparison of 3057 patients with diabetic painful neuropathy and fibromyalgia

BMC Neurology ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Jana Koroschetz ◽  
Stefanie E Rehm ◽  
Ulrich Gockel ◽  
Mathias Brosz ◽  
Rainer Freynhagen ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Painful Neuropathy ◽  
Diabetic Painful Neuropathy

scholarly journals Characteristics of Combination Pharmacotherapy in Patients with Diabetic Painful Neuropathy (DPN)

2015 ◽  
Vol 18 (3) ◽  
pp. A299
Author(s):  
K. Kuo ◽  
D. Brixner ◽  
A. Lipman ◽  
M. Hung ◽  
G. Oderda
Keyword(s):  
Painful Neuropathy ◽  
Diabetic Painful Neuropathy ◽  
Combination Pharmacotherapy
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