Mechanisms of Therapeutic Effects of Conditioned Media from Cultured Dental Pulp Stem Cells on Diabetic Polyneuropathy

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 554-P
Author(s):  
ERIKO MAKINO ◽  
NOBUHISA NAKAMURA ◽  
MEGUMI MIYABE ◽  
MIZUHO ITO ◽  
SAKI KANADA ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Diabetic Polyneuropathy ◽  
Dental Pulp Stem Cells ◽  
Conditioned Media ◽  
Therapeutic Effects

scholarly journals Direct Comparison of Therapeutic Effects on Diabetic Polyneuropathy between Transplantation of Dental Pulp Stem Cells and Administration of Dental Pulp Stem Cell-Secreted Factors

2020 ◽  
Vol 21 (17) ◽  
pp. 6064
Author(s):  
Saki Kanada ◽  
Eriko Makino ◽  
Nobuhisa Nakamura ◽  
Megumi Miyabe ◽  
Mizuho Ito ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Sciatic Nerve ◽  
Dental Pulp ◽  
Skeletal Muscles ◽  
Diabetic Polyneuropathy ◽  
Diabetic Rats ◽  
Dental Pulp Stem Cells ◽  
Therapeutic Effects ◽  
Secreted Factors

Stem cell transplantation is a potential novel therapy for diabetic polyneuropathy. Dental pulp stem cells (DPSCs) are attractive stem cell sources because DPSCs can be isolated from extracted teeth and cryopreserved while retaining viability. In this study, we directly compared the efficacy of the transplantation of DPSCs and the administration of the secreted factors from DPSCs (DPSC-SFs) on diabetic polyneuropathy. Eight weeks after streptozotocin injection, DPSCs (1.0 × 106 cells/rat) or DPSC-SFs (1.0 mL/rat) were administered into the unilateral hindlimb skeletal muscles of diabetic Sprague–Dawley rats. DPSC transplantation and DPSC-SF administration did not affect blood glucose levels and body weights in the diabetic rats. Both DPSC transplantation and DPSC-SF administration significantly ameliorated sciatic nerve conduction velocity and sciatic nerve blood flow, accompanied by increases in muscle bundle size, vascular density in the skeletal muscles and intraepidermal nerve fiber density in the diabetic rats, while there was no difference between the results for DPSCs and DPSC-SFs. These results suggest that the efficacy of both DPSC transplantation and DPSC-SF administration for diabetic polyneuropathy four weeks after transplantation/administration was mainly due to the multiple secretomes secreted from transplanted DPSCs or directly injected DPSC-SFs in the early phase of transplantation/administration.

Conditioned media derived from dental pulp stem cells prevent myocardial ischemic injury

2015 ◽  
Vol 44 ◽  
pp. e309
Author(s):  
S. Yamaguchi ◽  
R. Shibata ◽  
N. Yamamoto ◽  
M. Nishikawa ◽  
T. Murohara ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Ischemic Injury ◽  
Dental Pulp Stem Cells ◽  
Conditioned Media ◽  
Myocardial Ischemic Injury

Secreted Factors from Dental Pulp Stem Cells Ameliorated Diabetic Polyneuropathy in Streptozotocin-Induced Diabetic Mice

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 566-P
Author(s):  
EMIRI MIURA-YURA ◽  
SHIN TSUNEKAWA ◽  
TATSUHITO HIMENO ◽  
KEIKO NARUSE ◽  
MIKIO MOTEGI ◽  
...  
Keyword(s):  
Stem Cells ◽  
Dental Pulp ◽  
Diabetic Polyneuropathy ◽  
Dental Pulp Stem Cells ◽  
Diabetic Mice ◽  
Secreted Factors

549-P: Transplantation of Human Dental Pulp Stem Cells Ameliorates Diabetic Polyneuropathy via Increasing Angiogenic and Neurotrophic Gene Expression in the Transplanted Muscles

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 549-P
Author(s):  
MASAKI HATA ◽  
MAIKO OMI ◽  
NOBUHISA NAKAMURA ◽  
MEGUMI MIYABE ◽  
MIZUHO ITO ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Dental Pulp ◽  
Diabetic Polyneuropathy ◽  
Dental Pulp Stem Cells ◽  
Human Dental Pulp
Sign in / Sign up

Export Citation Format

Share Document