Diabetic Retinopathy Reversed by Intravitreous Application of Retinol Binding Protein 3

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 245-OR
Author(s):  
HISASHI YOKOMIZO ◽  
KYOUNGMIN PARK ◽  
ALLEN CLERMONT ◽  
YASUTAKA MAEDA ◽  
WARD FICKWEILER ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Binding Protein ◽  
Retinol Binding Protein

586-P: Vitreous and Serum Measurements of Retinol Binding Protein 3 in the Clinical Evaluation of Diabetic Retinopathy

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 586-P
Author(s):  
WARD FICKWEILER ◽  
HISASHI YOKOMIZO ◽  
KYOUNGMIN PARK ◽  
SAMANTHA M. PANIAGUA ◽  
I-HSIEN WU ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Clinical Evaluation ◽  
Binding Protein ◽  
Retinol Binding Protein

87-OR: Vitreous Retinol Binding Protein 3 Is Increased in Patients without Advanced Diabetic Retinopathy in Type 1 and Type 2 Diabetes

Diabetes ◽  
2021 ◽  
Vol 70 (Supplement 1) ◽  
pp. 87-OR
Author(s):  
WARD FICKWEILER ◽  
HYUNSEOK PARK ◽  
KYOUNGMIN PARK ◽  
TAHANI BOUMENNA ◽  
JOHN GAUTHIER ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Retinopathy ◽  
Binding Protein ◽  
Retinol Binding Protein

scholarly journals Retinol binding protein 3 is increased in the retina of patients with diabetes resistant to diabetic retinopathy

2019 ◽  
Vol 11 (499) ◽  
pp. eaau6627 ◽  
Author(s):  
Hisashi Yokomizo ◽  
Yasutaka Maeda ◽  
Kyoungmin Park ◽  
Allen C. Clermont ◽  
Sonia L. Hernandez ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Glucose Uptake ◽  
Inflammatory Cytokines ◽  
Glucose Transporter ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Therapeutic Effects ◽  
Vegf Receptor ◽  
Inverse Association ◽  
Glucose Transporter 1

The Joslin Medalist Study characterized people affected with type 1 diabetes for 50 years or longer. More than 35% of these individuals exhibit no to mild diabetic retinopathy (DR), independent of glycemic control, suggesting the presence of endogenous protective factors against DR in a subpopulation of patients. Proteomic analysis of retina and vitreous identified retinol binding protein 3 (RBP3), a retinol transport protein secreted mainly by the photoreceptors, as elevated in Medalist patients protected from advanced DR. Mass spectrometry and protein expression analysis identified an inverse association between vitreous RBP3 concentration and DR severity. Intravitreal injection and photoreceptor-specific overexpression of RBP3 in rodents inhibited the detrimental effects of vascular endothelial growth factor (VEGF). Mechanistically, our results showed that recombinant RBP3 exerted the therapeutic effects by binding and inhibiting VEGF receptor tyrosine phosphorylation. In addition, by binding to glucose transporter 1 (GLUT1) and decreasing glucose uptake, RBP3 blocked the detrimental effects of hyperglycemia in inducing inflammatory cytokines in retinal endothelial and Müller cells. Elevated expression of photoreceptor-secreted RBP3 may have a role in protection against the progression of DR due to hyperglycemia by inhibiting glucose uptake via GLUT1 and decreasing the expression of inflammatory cytokines and VEGF.

597-P: Retinol Binding Protein 3 in Diabetic Retinopathy: Mechanisms of Protective Activity

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 597-P
Author(s):  
HISASHI YOKOMIZO ◽  
KYOUNGMIN PARK ◽  
ALLEN CLERMONT ◽  
YASUTAKA MAEDA ◽  
WARD FICKWEILER ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Protective Activity

327-OR: Association of Retinol Binding Protein 3 with Retinal Neural Structure and Clinical Parameters in Diabetic Retinopathy

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 327-OR
Author(s):  
WARD FICKWEILER ◽  
KYOUNGMIN PARK ◽  
EMILY WOLFSON ◽  
HYUNSEOK PARK ◽  
HISASHI YOKOMIZO ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Binding Protein ◽  
Retinol Binding Protein ◽  
Clinical Parameters ◽  
Neural Structure

scholarly journals Retinol binding protein 3 as biomarker for diabetic retinopathy

2019 ◽  
Vol 7 (22) ◽  
pp. 706-706
Author(s):  
Ward Fickweiler ◽  
Lloyd P. Aiello ◽  
Jennifer K. Sun ◽  
George L. King
Keyword(s):  
Diabetic Retinopathy ◽  
Binding Protein ◽  
Retinol Binding Protein
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