IER3IP1 Regulates Beta-Cell Survival

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 2103-P
Author(s):  
JUAN SUN ◽  
KENNETH POLONSKY ◽  
DECHENG REN
Keyword(s):  
Beta Cell ◽  
Cell Survival

2123-P: Peroxiredoxin6 Is a Novel Promoter of Pancreatic Beta-Cell Survival

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 2123-P
Author(s):  
FRANCESCA PACIFICI ◽  
DAVID DELLA-MORTE ◽  
BARBARA CAPUANI ◽  
DONATELLA PASTORE ◽  
ROBERTO ARRIGA ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Survival ◽  
Pancreatic Beta Cell

W46 ROLE OF LIPOPROTEINS IN PANCREATIC BETA-CELL SURVIVAL, PROLIFERATION AND FUNCTION

2010 ◽  
Vol 11 (2) ◽  
pp. 10
Author(s):  
R.A. Sibler ◽  
S. Rütti ◽  
J.A. Ehses ◽  
R. Prazak ◽  
D.T. Meier ◽  
...  
Keyword(s):  
Beta Cell ◽  
Cell Survival ◽  
Pancreatic Beta Cell ◽  
And Function

Osteoprotegerin, a Novel Downstream Target of Lactogens, Directly Enhances Human Beta-Cell Survival and Proliferation

2011 ◽  
pp. P2-488-P2-488
Author(s):  
Nagesha Guthalu Kondegowda ◽  
Anthony Otero ◽  
Anais Mozar ◽  
Connie Chin ◽  
Rupangi C Vasavada
Keyword(s):  
Beta Cell ◽  
Cell Survival ◽  
Downstream Target ◽  
Human Beta Cell ◽  
Cell Survival And Proliferation

Differential Importance of Glucose-Dependent Insulinotropic Polypeptide vs Glucagon-Like Peptide 1 Receptor Signaling for Beta Cell Survival in Mice

2009 ◽  
Vol 137 (6) ◽  
pp. 2146-2157 ◽  
Author(s):  
Adriano Maida ◽  
Tanya Hansotia ◽  
Christine Longuet ◽  
Yutaka Seino ◽  
Daniel J. Drucker
Keyword(s):  
Beta Cell ◽  
Cell Survival ◽  
Receptor Signaling ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1

scholarly journals Loss of Free Fatty Acid Receptor 2 leads to impaired islet mass and beta cell survival

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Stephanie R. Villa ◽  
Medha Priyadarshini ◽  
Miles H. Fuller ◽  
Tanya Bhardwaj ◽  
Michael R. Brodsky ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Free Fatty Acid ◽  
Beta Cell ◽  
Cell Survival ◽  
Acid Receptor ◽  
Islet Mass ◽  
Free Fatty Acid Receptor ◽  
Fatty Acid Receptor

Ceramide formation as a target in beta-cell survival and function

2011 ◽  
Vol 15 (9) ◽  
pp. 1061-1071 ◽  
Author(s):  
Florian Lang ◽  
Susanne Ullrich ◽  
Erich Gulbins
Keyword(s):  
Beta Cell ◽  
Cell Survival ◽  
And Function

scholarly journals Type 1 diabetes risk genes mediate pancreatic beta cell survival in response to proinflammatory cytokines

2021 ◽  
Author(s):  
Paola Benaglio ◽  
Han Zhu ◽  
Mei-Lin Okino ◽  
Jian Yan ◽  
Ruth Elgamal ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Cell Survival ◽  
Beta Cells ◽  
High Throughput ◽  
Proinflammatory Cytokines ◽  
Pancreatic Beta Cell ◽  
Regulatory Elements ◽  
A Genome

Beta cells intrinsically contribute to the pathogenesis of type 1 diabetes (T1D), but the genes and molecular processes that mediate beta cell survival in T1D remain largely unknown. We combined high throughput functional genomics and human genetics to identify T1D risk loci regulating genes affecting beta cell survival in response to the proinflammatory cytokines IL-1b, IFNg, and TNFa. We mapped 38,931 cytokine-responsive candidate cis-regulatory elements (cCREs) active in beta cells using ATAC-seq and single nuclear ATAC-seq (snATAC-seq), and linked cytokine-responsive beta cell cCREs to putative target genes using single cell co-accessibility and HiChIP. We performed a genome-wide pooled CRISPR loss-of-function screen in EndoC-betaH1 cells, which identified 867 genes affecting cytokine-induced beta cell loss. Genes that promoted beta cell survival and had up-regulated expression in cytokine exposure were specifically enriched at T1D loci, and these genes were preferentially involved in inhibiting inflammatory response, ubiquitin-mediated proteolysis, mitophagy and autophagy. We identified 2,229 variants in cytokine-responsive beta cell cCREs altering transcription factor (TF) binding using high-throughput SNP-SELEX, and variants altering binding of TF families regulating stress, inflammation and apoptosis were broadly enriched for T1D association. Finally, through integration with genetic fine mapping, we annotated T1D loci regulating beta cell survival in cytokine exposure. At the 16p13 locus, a T1D variant affected TF binding in a cytokine-induced beta cell cCRE that physically interacted with the SOCS1 promoter, and increased SOCS1 activity promoted beta cell survival in cytokine exposure. Together our findings reveal processes and genes acting in beta cells during cytokine exposure that intrinsically modulate risk of T1D.

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