Vitamin D, Prediabetes, and Diabetes—Bidirectional Mendelian Randomization Analysis

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1602-P
Author(s):  
NINGJIAN WANG ◽  
LI ZHAO ◽  
CHI CHEN ◽  
YI CHEN ◽  
YINGLI LU
Keyword(s):  
Vitamin D ◽  
Mendelian Randomization ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Observational and Causal Association of Blood Vitamin D with Gut Microbiota: Evidence from a Prospective Cohort and Mendelian Randomization Analysis

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1513-1513
Author(s):  
Ju-Sheng Zheng ◽  
Xu Fengzhe ◽  
Yu-Ming Chen
Keyword(s):  
Vitamin D ◽  
Gut Microbiota ◽  
Prospective Cohort ◽  
Mendelian Randomization ◽  
Vitamin D Status ◽  
Causal Association ◽  
Mendelian Randomization Analysis ◽  
Prospective Association ◽  
Randomization Analysis ◽  
Microbiota Diversity

Abstract Objectives Little is known about the relationship between blood vitamin D status and gut microbiota. We aimed to investigate the prospective association of blood 25-hydroxyvitamin D (25(OH)D) with gut microbiota and assess their potential causal relationship. Methods Our study was based on the Guangzhou Nutrition and Health Study, a community-based prospective cohort in China. We examined the prospective association of baseline 25(OH)D with gut microbiota diversity, composition and individual taxa (mean 4.3 years of follow-up) (n = 1757) using linear or logistic regression models. Using genetic variants as instrument variables, we used a Mendelian randomization analysis to assess the causal relationship between 25(OH)D and gut microbiota. Results Higher blood 25(OH)D levels were associated with higher alpha-diversity indicators: including Chao1 index, Shannon index and Observed OUTs index (all P < 0.01, comparing extreme quartiles (Q) of 25(OH)D). Significant difference (P < 0.01) in beta-diversity was also found between Q1 and Q4 of 25(OH)D. Meanwhile, high 25(OH)D (Q4 versus Q1) was prospectively associated with the gut enterotype (Prevotella) and with differences in 37 individual taxa of gut microbiota (P < 0.05). Mendelian randomization analysis suggested that higher 25(OH)D was causally associated with higher abundance of Erysipelotrichaceae and with presence of Rothia. Conclusions Blood vitamin D status is prospectively associated with future gut microbiota diversity and composition. Available evidence suggests a potential causal association of vitamin D with some gut bacteria, and more research is needed to confirm these results. Funding Sources National Natural Science Foundation of China (81,903,316, 81,773,416).

scholarly journals Causal Relationship between Obesity and Vitamin D Status: Bi-Directional Mendelian Randomization Analysis of Multiple Cohorts

PLoS Medicine ◽  
2013 ◽  
Vol 10 (2) ◽  
pp. e1001383 ◽  
Author(s):  
Karani S. Vimaleswaran ◽  
Diane J. Berry ◽  
Chen Lu ◽  
Emmi Tikkanen ◽  
Stefan Pilz ◽  
...  
Keyword(s):  
Vitamin D ◽  
Causal Relationship ◽  
Mendelian Randomization ◽  
Vitamin D Status ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals 25-Hydroxyvitamin D and Risk of Osteoporotic Fractures: Mendelian Randomization Analysis in 2 Large Population-Based Cohorts

2020 ◽  
Vol 66 (5) ◽  
pp. 676-685 ◽  
Author(s):  
Yunus Çolak ◽  
Shoaib Afzal ◽  
Børge G Nordestgaard
Keyword(s):  
Vitamin D ◽  
Mendelian Randomization ◽  
Osteoporotic Fractures ◽  
Population Based ◽  
Hydroxyvitamin D ◽  
Mendelian Randomization Analysis ◽  
Hazard Ratios ◽  
Increased Risk ◽  
25 Hydroxyvitamin D ◽  
Randomization Analysis

Abstract Background Whether low plasma 25-hydroxyvitamin D concentrations cause osteoporotic fractures is unclear. We tested the hypothesis that low plasma 25-hydroxyvitamin D concentrations are associated with increased risk of osteoporotic fractures using a Mendelian randomization analysis. Methods We genotyped 116 335 randomly chosen white Danish persons aged 20–100 years in 2 population-based cohort studies for plasma 25-hydroxyvitamin D decreasing genotypes in CYP2R1 (rs117913124 and rs12794714), DHCR7 (rs7944926 and rs11234027), GEMIN2 (rs2277458), and HAL (rs3819817); 35 833 had information on plasma 25-hydroxyvitamin D. We assessed risk of total, osteoporotic, and anatomically localized fractures from 1981 through 2017. Information on fractures and vital status was obtained from nationwide registries. Results During up to 36 years of follow-up, we observed 17 820 total fractures, 10 861 osteoporotic fractures, and 3472 fractures of hip or femur. Compared with individuals with 25-hydroxyvitamin D ≥ 50nmol/L, multivariable adjusted hazard ratios (95% CIs) for total fractures were 1.03 (0.97–1.09) for individuals with 25–49.9 nmol/L, 1.19 (1.10–1.28) for individuals with 12.5–24.9 nmol/L, and 1.39 (1.21–1.60) for individuals with 25-hydroxyvitamin D < 12.5 nmol/L. Corresponding hazard ratios were 1.07 (1.00–1.15), 1.25 (1.13–1.37), and 1.49 (1.25–1.77) for osteoporotic fractures and 1.09 (0.98–1.22), 1.37 (1.18–1.57), and 1.41 (1.09–1.81) for fractures of hip or femur, respectively. Hazard ratios per 1 increase in vitamin D allele score, corresponding to 3.0% (approximately 1.6 nmol/L) lower 25-hydroxyvitamin D concentrations, were 0.99 (0.98–1.00) for total fractures, 0.99 (0.97–1.00) for osteoporotic fractures, and 0.98 (0.95–1.00) for fractures of hip or femur. Conclusions Low plasma 25-hydroxyvitamin D concentrations were associated with osteoporotic fractures; however, Mendelian randomization analysis provided no evidence supporting a causal role for vitamin D in the risk for osteoporotic fractures.

Vitamin D, prediabetes and type 2 diabetes: bidirectional Mendelian randomization analysis

2019 ◽  
Vol 59 (4) ◽  
pp. 1379-1388 ◽  
Author(s):  
Ningjian Wang ◽  
Chiyu Wang ◽  
Xiaoman Chen ◽  
Heng Wan ◽  
Yi Chen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Vitamin D ◽  
Mendelian Randomization ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis

scholarly journals Mendelian randomization analysis demonstrates that low vitamin D is unlikely causative for pediatric asthma

2016 ◽  
Vol 138 (6) ◽  
pp. 1747-1749.e4 ◽  
Author(s):  
Erik B. Hysinger ◽  
Jeffrey D. Roizen ◽  
Frank D. Mentch ◽  
Lyam Vazquez ◽  
John J. Connolly ◽  
...  
Keyword(s):  
Vitamin D ◽  
Mendelian Randomization ◽  
Pediatric Asthma ◽  
Mendelian Randomization Analysis ◽  
Randomization Analysis
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