Dapagliflozin plus Saxagliptin Add-On to Metformin Reduces Liver Fat and Adipose Tissue Volume in Patients with Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1175-P
Author(s):  
JOHN P. WILDING ◽  
PAUL HOCKINGS ◽  
EVA K. JOHNSSON ◽  
JILL MAASKE ◽  
RICARDO GARCIA-SANCHEZ ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Liver Fat ◽  
Tissue Volume ◽  
Adipose Tissue Volume

scholarly journals Dapagliflozin plus saxagliptin add‐on to metformin reduces liver fat and adipose tissue volume in patients with type 2 diabetes

2020 ◽  
Vol 22 (7) ◽  
pp. 1094-1101 ◽  
Author(s):  
Lars Johansson ◽  
Paul D. Hockings ◽  
Eva Johnsson ◽  
Nalina Dronamraju ◽  
Jill Maaske ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Liver Fat ◽  
Tissue Volume ◽  
Adipose Tissue Volume

Effect of Type 2 Diabetes Mellitus on Epicardial Adipose Tissue Volume and Coronary Vasomotor Function

2014 ◽  
Vol 113 (1) ◽  
pp. 90-97 ◽  
Author(s):  
Weena J.Y. Chen ◽  
Ibrahim Danad ◽  
Pieter G. Raijmakers ◽  
Rick Halbmeijer ◽  
Hendrik J. Harms ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Tissue Volume ◽  
Vasomotor Function ◽  
Adipose Tissue Volume ◽  
Coronary Vasomotor Function

scholarly journals Genetic Evidence for Different Adiposity Phenotypes and their Opposing Influence on Ectopic Fat and Risk of Cardiometabolic Disease

2021 ◽  
Author(s):  
Susan Martin ◽  
Madeleine Cule ◽  
Nicolas Basty ◽  
Jessica Tyrrell ◽  
Robin N. Beaumont ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Metabolic Profile ◽  
Liver Fat ◽  
Metabolic Effects ◽  
Ectopic Fat ◽  
Alcoholic Fatty Liver ◽  
Cardiometabolic Diseases ◽  
Risk Of Disease

To understand the causal role of adiposity and ectopic fat in type 2 diabetes and cardiometabolic diseases, we aimed to identify two clusters of adiposity genetic variants, one with ‘adverse’ metabolic effects (UFA) and the other with, paradoxically, ‘favourable’ metabolic effects (FA). We performed a multivariate genome-wide association study using body fat percentage and metabolic biomarkers from UK Biobank and identified 38 UFA and 36 FA variants. Adiposity-increasing alleles were associated with an adverse metabolic profile, higher risk of disease, higher CRP, higher fat in subcutaneous and visceral adipose tissue, liver and pancreas for UFA; and a favourable metabolic profile, lower risk of disease, higher CRP, higher subcutaneous adipose tissue but lower liver fat for FA. We detected no sexual dimorphism. The Mendelian randomization studies provided evidence for risk-increasing effect of UFA and protective effect of FA on type 2 diabetes, heart disease, hypertension, stroke, non-alcoholic fatty liver disease and polycystic ovary syndrome. FA is distinct from UFA by its association with lower liver fat, and protection from cardiometabolic diseases; it was not associated with visceral or pancreatic fat. Understanding the difference in FA and UFA may lead to new insights in preventing, predicting and treating of cardiometabolic diseases.

Increased Liver Fat, Impaired Insulin Clearance, and Hepatic and Adipose Tissue Insulin Resistance in Type 2 Diabetes

2008 ◽  
Vol 135 (1) ◽  
pp. 122-130 ◽  
Author(s):  
Anna Kotronen ◽  
Leena Juurinen ◽  
Mirja Tiikkainen ◽  
Satu Vehkavaara ◽  
Hannele Yki–Järvinen
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Insulin Clearance ◽  
Liver Fat ◽  
Impaired Insulin

Liver fat in obesity: role of type 2 diabetes mellitus and adipose tissue distribution

2010 ◽  
Vol 41 (1) ◽  
pp. 39-44 ◽  
Author(s):  
Lutgarda Bozzetto ◽  
Anna Prinster ◽  
Marcello Mancini ◽  
Rosalba Giacco ◽  
Claudia De Natale ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Adipose Tissue ◽  
Tissue Distribution ◽  
Liver Fat ◽  
Adipose Tissue Distribution

Liver fat content is linked to inflammatory changes in subcutaneous adipose tissue in type 2 diabetes patients

2013 ◽  
pp. n/a-n/a
Author(s):  
Henry J. Jansen ◽  
Gerald M. Vervoort ◽  
Marinette van der Graaf ◽  
Rinke Stienstra ◽  
Cees J. Tack
Keyword(s):  
Type 2 Diabetes ◽  
Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Subcutaneous Adipose ◽  
Inflammatory Changes ◽  
Diabetes Patients
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