Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

Amar Abderrahmani; Loïc Yengo; Robert Caiazzo; Mickaël Canouil; Stéphane Cauchi; Violeta Raverdy; Valérie Plaisance; Valérie Pawlowski; Stéphane Lobbens; Julie Maillet; Laure Rolland; Raphael Boutry; Gurvan Queniat; Maxime Kwapich; Mathie Tenenbaum; Julien Bricambert; Sophie Saussenthaler; Elodie Anthony; Pooja Jha; Julien Derop; Olivier Sand; Iandry Rabearivelo; Audrey Leloire; Marie Pigeyre; Martine Daujat-Chavanieu; Sabine Gerbal-Chaloin; Tasnim Dayeh; Guillaume Lassailly; Philippe Mathurin; Bart Staels; Johan Auwerx; Annette Schürmann; Catherine Postic; Clemens Schafmayer; Jochen Hampe; Amélie Bonnefond; François Pattou; Philippe Froguel

doi:10.2337/db17-1539

Increased Hepatic PDGF-AA Signaling Mediates Liver Insulin Resistance in Obesity-Associated Type 2 Diabetes

Diabetes ◽

10.2337/db17-1539 ◽

2018 ◽

Vol 67 (7) ◽

pp. 1310-1321 ◽

Cited By ~ 24

Author(s):

Amar Abderrahmani ◽

Loïc Yengo ◽

Robert Caiazzo ◽

Mickaël Canouil ◽

Stéphane Cauchi ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Liver Insulin Resistance

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Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia

Diabetes ◽

10.2337/diabetes.49.11.1880 ◽

2000 ◽

Vol 49 (11) ◽

pp. 1880-1889 ◽

Cited By ~ 370

Author(s):

N. Kubota ◽

K. Tobe ◽

Y. Terauchi ◽

K. Eto ◽

T. Yamauchi ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Beta Cell ◽

Insulin Receptor ◽

Insulin Receptor Substrate ◽

Cell Hyperplasia ◽

Beta Cell Hyperplasia ◽

Liver Insulin Resistance

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Abstract #162: Dramatic Reduction in Insulin Requirement after Starting Continuous Subcutaneous Insulin Infusion Using U500 Insulin in a Patient With Type 2 Diabetes and Severe Insulin Resistance

Endocrine Practice ◽

10.1016/s1530-891x(20)43960-6 ◽

2006 ◽

Vol 12 ◽

pp. 10

Author(s):

Thottathil Gopan ◽

Elias Siraj

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Continuous Subcutaneous Insulin Infusion ◽

Insulin Infusion ◽

Insulin Requirement ◽

Dramatic Reduction ◽

Subcutaneous Insulin ◽

Severe Insulin Resistance

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Relationship between anthropometric indices and insulin resistance in Nigerians with type 2 diabetes mellitus

Endocrine Abstracts ◽

10.1530/endoabs.38.p294 ◽

2015 ◽

Author(s):

Chikezie Onwukwe ◽

Nkiru Chikezie

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Anthropometric Indices

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Circulating adipokine levels and insulin resistance in type 2 diabetes mellitus and metabolic syndrome

Endocrine Abstracts ◽

10.1530/endoabs.41.ep452 ◽

2016 ◽

Author(s):

Sitwat Zehra ◽

Mozaffer Rahim Hingorjo ◽

Erum Imran ◽

Masood Anwar Qureshi

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Metabolic Syndrome ◽

Type 2 Diabetes Mellitus

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Modification of lifestyle and influence on leptin and insulin resistance to prevent type 2 diabetes mellitus

Endocrine Abstracts ◽

10.1530/endoabs.49.ep591 ◽

2017 ◽

Author(s):

Shishko Elena ◽

Mokhort Elena

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus

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The prevalence of impaired cognitive function and depression in patients with type 2 diabetes mellitus and severe insulin resistance

Endocrine Abstracts ◽

10.1530/endoabs.63.p961 ◽

2019 ◽

Author(s):

Diana Šimonienę ◽

Džilda Veličkienę

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Cognitive Function ◽

Severe Insulin Resistance ◽

Impaired Cognitive Function

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Trabecular bone score and insulin resistance in type 2 diabetes mellitus

Endocrine Abstracts ◽

10.1530/endoabs.70.aep1043 ◽

2020 ◽

Author(s):

Ponce Maria Hayon ◽

Laguna Mª del Carmen Serrano ◽

Perez Maria Dolores Aviles ◽

Beatriz Garcia Fontana ◽

Sheila Gonzalez Salvatierra ◽

...

Keyword(s):

Diabetes Mellitus ◽

Insulin Resistance ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Trabecular Bone ◽

Trabecular Bone Score

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1516-P: A Comparison of the Contributions of Impaired Insulin Secretion and Insulin Resistance to the Development of Type 2 Diabetes in a Japanese Community: The Hisayama Study

Diabetes ◽

10.2337/db19-1516-p ◽

2019 ◽

Vol 68 (Supplement 1) ◽

pp. 1516-P

Author(s):

MASAHITO YOSHINARI ◽

YOICHIRO HIRAKAWA ◽

JUN HATA ◽

MAYU HIGASHIOKA ◽

TAKANORI HONDA ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Insulin Secretion ◽

Impaired Insulin Secretion ◽

Impaired Insulin

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1758-P: Type 2 Diabetes–Associated Mood Disorders: Role of Insulin Resistance in Serotonergic Neurons

Diabetes ◽

10.2337/db20-1758-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 1758-P

Author(s):

HUGO MARTIN ◽

SÉBASTIEN BULLICH ◽

FABIEN DUCROCQ ◽

MARION GRALAND ◽

CLARA OLIVRY ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Mood Disorders ◽

Serotonergic Neurons ◽

P Type

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1746-P: Obese Youth with Type 1 Diabetes (T1D) Have Worse Hepatic Insulin Resistance (IR) Than Youth with Type 2 Diabetes (T2D)

Diabetes ◽

10.2337/db20-1746-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 1746-P

Author(s):

PATTARA WIROMRAT ◽

MELANIE CREE-GREEN ◽

BRYAN C. BERGMAN ◽

KALIE L. TOMMERDAHL ◽

AMY BAUMGARTNER ◽

...

Keyword(s):

Insulin Resistance ◽

Type 2 Diabetes ◽

Type 1 Diabetes ◽

Hepatic Insulin Resistance ◽

Obese Youth

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