scholarly journals Cannabinoid Type 1 Receptors Are Upregulated During Acute Activation of Brown Adipose Tissue

Diabetes ◽  
2018 ◽  
Vol 67 (7) ◽  
pp. 1226-1236 ◽  
Author(s):  
Minna Lahesmaa ◽  
Olof Eriksson ◽  
Thorsten Gnad ◽  
Vesa Oikonen ◽  
Marco Bucci ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose

Inhibition of Type 1 Iodothyronine Deiodinase by Bisphenol A

2019 ◽  
Vol 51 (10) ◽  
pp. 671-677 ◽  
Author(s):  
Maurício Martins da Silva ◽  
Carlos Frederico Lima Gonçalves ◽  
Leandro Miranda-Alves ◽  
Rodrigo Soares Fortunato ◽  
Denise P. Carvalho ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Thyroid Hormone ◽  
Bisphenol A ◽  
Brown Adipose Tissue ◽  
Tissue Type ◽  
Deiodinase Activity ◽  
Brown Adipose

AbstractPlastics are ubiquitously present in our daily life and some components of plastics are endocrine-disrupting chemicals, such as bisphenol A and phthalates. Herein, we aimed to evaluate the effect of plastic endocrine disruptors on type 1 and type 2 deiodinase activities, enzymes responsible for the conversion of the pro-hormone T4 into the biologically active thyroid hormone T3, both in vitro and in vivo. Initially, we incubated rat liver type 1 deiodinase and brown adipose tissue type 2 deiodinase samples with 0.5 mM of the plasticizers, and the deiodinase activity was measured. Among them, only BPA was capable to inhibit both type 1 and type 2 deiodinases. Then, adult male Wistar rats were treated orally with bisphenol A (40 mg/kg b.w.) for 15 days and hepatic type 1 deiodinase and brown adipose tissue type 2 deiodinase activities and serum thyroid hormone concentrations were measured. In vivo bisphenol A treatment significantly reduced hepatic type 1 deiodinase activity but did not affect brown adipose tissue type 2 deiodinase activity. Serum T4 levels were higher in bisphenol A group, while T3 remained unchanged. T3/T4 ratio was decreased in rats treated with bisphenol A, reinforcing the idea that peripheral metabolism of thyroid hormone was affected by bisphenol A exposure. Therefore, our results suggest that bisphenol A can affect the metabolism of thyroid hormone thus disrupting thyroid signaling.

scholarly journals Metabolically Active Brown Adipose Tissue Is Found in Adult Subjects with Type 1 Diabetes

2019 ◽  
Vol 20 (23) ◽  
pp. 5827 ◽  
Author(s):  
Eriksson ◽  
Selvaraju ◽  
Berglund ◽  
Espes
Keyword(s):  
Skeletal Muscle ◽  
Type 1 Diabetes ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Metabolic Control ◽  
Metabolic Activity ◽  
Glucose Utilization ◽  
Insulin Requirements ◽  
Brown Adipose

Type 1 diabetes (T1D) is characterized by the loss of insulin-producing cells and hence insulin secretion and metabolic control. In addition to insulin, there are a number of hormones and cytokines that influence metabolism, and many of these can be secreted from brown adipose tissue (BAT). However, the presence and activity of BAT in T1D have not been studied, despite the fact that preclinical studies have shown that transplantation of BAT in mouse models of T1D can restore metabolic control. The metabolic activity of BAT, white adipose tissue (WAT), and skeletal muscle was investigated in patients with T1D (n = 11) by 2-deoxy-2-(18F)fluoro-D-glucose PET/CT after cold stimulation. Functional BAT was detected in 4 out of 11 individuals with T1D with a prevalence of 36%. The glucose utilization rate in the supraclavicular BAT regions ranged from 0.75–38.7 µmol × min−1 × 100 g−1. The glucose utilization per gram tissue was higher in BAT when compared with both WAT (p = 0.049) and skeletal muscle (p = 0.039). However, no correlation between BAT activity and metabolic control or insulin requirements was found. In conclusion, for the first time, cold-induced BAT was detected in patients with T1D with a wide range in metabolic activity. Contrary to findings in animal models, the metabolic activity of BAT had negligible impact on insulin requirements or metabolic control in T1D under normal physiological conditions.

scholarly journals Deiodinase Activities in Thyroids and Tissues of Iodine-Deficient Female Rats

Endocrinology ◽  
2013 ◽  
Vol 154 (1) ◽  
pp. 529-536 ◽  
Author(s):  
Rosalia Lavado-Autric ◽  
Rosa Maria Calvo ◽  
Raquel Martinez de Mena ◽  
Gabriella Morreale de Escobar ◽  
Maria-Jesus Obregon
Keyword(s):  
Skeletal Muscle ◽  
Adipose Tissue ◽  
Cerebral Cortex ◽  
Brown Adipose Tissue ◽  
Female Rats ◽  
Iodothyronine Deiodinase ◽  
Brown Adipose ◽  
Type 3

Severe iodine deficiency is characterized by goiter, preferential synthesis, and secretion of T3 in thyroids, hypothyroxinemia in plasma and tissues, normal or low plasma T3, and slightly increased plasma TSH. We studied changes in deiodinase activities and mRNA in several tissues of rats maintained on low-iodine diets (LIDs) or LIDs supplemented with iodine (LID+I). T4 and T3 concentrations decreased in plasma, tissues, and thyroids of LID rats, and T4 decreased more than T3 (50%). The highest type 1 iodothyronine deiodinase (D1) activities were found in the thyroid, kidney, and the liver; pituitary, lung, and ovary had lower D1 activities; but the lowest levels were found in the heart and skeletal muscle. D1 activity decreased in all tissues of LID rats (10–40% of LID+I rats), except for ovary and thyroids, which D1 activity increased 2.5-fold. Maximal type 2 iodothyronine deiodinase (D2) activities were found in thyroid, brown adipose tissue, and pituitary, increasing 6.5-fold in thyroids of LID rats and about 20-fold in the whole gland. D2 always increased in response to LID, and maximal increases were found in the cerebral cortex (19-fold), thyroid, brown adipose tissue, and pituitary (6-fold). Lower D2 activities were found in the ovary, heart, and adrenal gland, which increased in LID. Type 3 iodothyronine deiodinase activity was undetectable. Thyroidal Dio1 and Dio2 mRNA increased in the LID rats, and Dio1 decreased in the lung, with no changes in mRNA expression in other tissues. Our data indicate that LID induces changes in deiodinase activities, especially in the thyroid, to counteract the low T4 synthesis and secretion, contributing to maintain the local T3 concentrations in the tissues with D2 activity.

scholarly journals Functional brown adipose tissue and sympathetic activity after cold exposure in humans with type 1 narcolepsy

SLEEP ◽  
2018 ◽  
Vol 41 (8) ◽  
Author(s):  
Lotte Hahn Enevoldsen ◽  
Marie Tindborg ◽  
Nichlas Lindegaard Hovmand ◽  
Christina Christoffersen ◽  
Helga Ellingsgaard ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Cold Exposure ◽  
Sympathetic Activity ◽  
Brown Adipose

Blunted Response of Pituitary Type 1 and Brown Adipose Tissue Type 2 Deiodinases to Swimming Training in Ovariectomized Rats

2012 ◽  
Vol 44 (11) ◽  
pp. 797-803 ◽  
Author(s):  
D. Ignacio ◽  
R. Fortunato ◽  
R.A. Neto ◽  
D. da Silva Silvestre ◽  
M. Nigro ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Ovariectomized Rats ◽  
Tissue Type ◽  
Swimming Training ◽  
Brown Adipose

scholarly journals Effect of suckling and adrenergic stimulation on peripheral deiodination in lactating rats: differential expression of type 1 deiodinase mRNA forms

2001 ◽  
Vol 171 (3) ◽  
pp. 533-540 ◽  
Author(s):  
C Aceves ◽  
R Rojas-Huidobro
Keyword(s):  
Adipose Tissue ◽  
Mammary Gland ◽  
Brown Adipose Tissue ◽  
Adrenergic Stimulation ◽  
Adrenergic Agonist ◽  
Large Form ◽  
Brown Adipose ◽  
Sympathetic Nervous ◽  
Beta Adrenergic Agonist

Previous works led us to propose that peripheral iodothyronine deiodination is mainly regulated by the reciprocal interaction between the thyroid and the sympathetic nervous system (SNS). In this study, we analyzed the role suckling exerts, through SNS activation, upon deiodination of thyronines in liver, heart, brown adipose tissue and mammary gland during lactation. Our results showed that resuckling causes a concurrent stimulatory response on deiodinase type 1 (D1) in heart and mammary gland, but not in liver and brown adipose tissue. The stimulatory response was mimicked by norepinephrine and by the beta-adrenergic agonist isoproterenol, through the overexpression of the large form of D1 mRNA. These results suggested that, during lactation, peripheral thyronine deiodination is co-ordinated by the SNS, and suckling is a major modulatory influence.

scholarly journals Role of Brown Adipose Tissue in Adiposity Associated With Narcolepsy Type 1

2020 ◽  
Vol 11 ◽  
Author(s):  
Maaike E. Straat ◽  
Mink S. Schinkelshoek ◽  
Rolf Fronczek ◽  
Gerrit Jan Lammers ◽  
Patrick C. N. Rensen ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Brown Adipose
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