scholarly journals Protein Kinase G Activation Reverses Oxidative Stress and Restores Osteoblast Function and Bone Formation in Male Mice With Type 1 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (4) ◽  
pp. 607-623 ◽  
Author(s):  
Hema Kalyanaraman ◽  
Gerburg Schwaerzer ◽  
Ghania Ramdani ◽  
Francine Castillo ◽  
Brian T. Scott ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 1 Diabetes ◽  
Protein Kinase ◽  
Bone Formation ◽  
Protein Kinase G ◽  
Male Mice ◽  
Osteoblast Function

Type 1 diabetes and oxidative stress markers

2021 ◽  
Vol 242 ◽  
pp. 174
Author(s):  
Widad Sobhi ◽  
Rania Derguine ◽  
Saliha Boucheffa ◽  
Abdelhalim Khenchouche ◽  
Nada Boutrid ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 1 Diabetes ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
And Oxidative Stress

Glutathione peroxidase-1 gene (GPX1) variants, oxidative stress and risk of kidney complications in people with type 1 diabetes

Metabolism ◽  
2016 ◽  
Vol 65 (2) ◽  
pp. 12-19 ◽  
Author(s):  
Kamel Mohammedi ◽  
Thiago A. Patente ◽  
Naima Bellili-Muñoz ◽  
Fathi Driss ◽  
Hervé Le Nagard ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 1 Diabetes ◽  
Glutathione Peroxidase ◽  
Glutathione Peroxidase 1

scholarly journals Mitochondrial Alterations and Enhanced Human Leukocyte/Endothelial Cell Interactions in Type 1 Diabetes

2020 ◽  
Vol 9 (7) ◽  
pp. 2155
Author(s):  
Francesca Iannantuoni ◽  
Aranzazu M. de Marañon ◽  
Zaida Abad-Jiménez ◽  
Francisco Canet ◽  
Pedro Díaz-Pozo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 1 Diabetes ◽  
Adhesion Molecules ◽  
Mitochondrial Function ◽  
Mitochondrial Membrane ◽  
Diabetic Patients ◽  
Ros Production ◽  
Mitochondrial Ros ◽  
Type 1 Diabetic Patients

Type 1 diabetes has been associated with oxidative stress. This study evaluates the rates of oxidative stress, mitochondrial function, leukocyte–endothelium interactions and adhesion molecules in type 1 diabetic patients. The study population consisted of 52 diabetic patients and 46 body-composition and age-matched controls. We assessed anthropometric and metabolic parameters, oxidative stress and mitochondrial function by evaluating reactive oxygen species (ROS) production, mitochondrial ROS production, mitochondrial membrane potential and superoxide dismutase (SOD) and catalase (CAT) expression in polymorphonuclear leukocytes from type 1 diabetic patients. In addition, we evaluated interactions between leukocytes and human umbilical vein endothelial cells (HUVEC), and serum expression of adhesion molecules (P-selectin, VCAM-1 and ICAM-1), proinflammatory cytokines (IL-6 and TNFα) and myeloperoxidase (MPO). HbA1C and glucose levels were higher in diabetic patients than in control subjects, as expected. Mitochondrial function was altered and leukocyte–endothelium interactions were enhanced in diabetic patients, which was evident in the increase in total and mitochondrial ROS production, higher mitochondrial membrane potential, enhanced leukocyte rolling and adhesion, and decreased rolling velocity. Furthermore, we observed an increase in levels of adhesion molecules P-selectin, VCAM-1, and ICAM-1 in these subjects. In addition, type 1 diabetic patients exhibited an increase in proinflammatory mediators TNFα and MPO, and a decreased expression of SOD. The enhancement of leukocyte–endothelium interactions and proinflammatory markers correlated with glucose and HbA1Clevels. Mitochondrial alteration, oxidative stress, and enhanced leukocyte–endothelium interactions are features of type 1 diabetes and may be related to cardiovascular implications.

Urinary oxidative stress markers in young patients with type 1 diabetes

2006 ◽  
Vol 48 (1) ◽  
pp. 58-61 ◽  
Author(s):  
IKUE HATA ◽  
MASAYUKI KAJI ◽  
SATOKO HIRANO ◽  
YOSUKE SHIGEMATSU ◽  
HIROKAZU TSUKAHARA ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 1 Diabetes ◽  
Young Patients ◽  
Oxidative Stress Markers ◽  
Stress Markers
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