scholarly journals Increased Effector Memory Insulin-Specific CD4 + T Cells Correlate With Insulin Autoantibodies in Patients With Recent-Onset Type 1 Diabetes

Diabetes ◽  
2017 ◽  
Vol 66 (12) ◽  
pp. 3051-3060 ◽  
Author(s):  
Justin A. Spanier ◽  
Nathanael L. Sahli ◽  
Joseph C. Wilson ◽  
Tijana Martinov ◽  
Thamotharampillai Dileepan ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Cd4 T Cells ◽  
Insulin Autoantibodies ◽  
Effector Memory ◽  
Recent Onset ◽  
Onset Type

scholarly journals Proteomic Landscape of Patient-Derived CD4+ T Cells in Recent-Onset Type 1 Diabetes

2017 ◽  
Vol 17 (1) ◽  
pp. 618-634 ◽  
Author(s):  
Marlen F. Lepper ◽  
Uli Ohmayer ◽  
Christine von Toerne ◽  
Nicole Maison ◽  
Anette-Gabriele Ziegler ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Cd4 T Cells ◽  
Recent Onset ◽  
Onset Type

scholarly journals CD4 CD25 T Cells in Children with Recent Onset Type 1 Diabetes

2021 ◽  
Vol 89 (6) ◽  
pp. 1079-1087
Author(s):  
MARWA FATHY, M.Sc.; IBRAHIM IBRAHIM M. EL ARABY, M.D. ◽  
NANCY M. EL GUINDY, M.D.; GHADA M. ANWAR, M.D.
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Recent Onset ◽  
Onset Type

scholarly journals One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI15-24

2021 ◽  
Author(s):  
Ada Admin ◽  
Teresa Rodriguez-Calvo ◽  
Lars Krogvold ◽  
Natalie Amirian ◽  
Knut Dahl-Jørgensen ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Cd8 T Cells ◽  
Pancreatic Tissue ◽  
Cell Reactivity ◽  
Tissue Samples ◽  
Recent Onset ◽  
Onset Type

In type 1 diabetes, a lifelong autoimmune disease, T cells infiltrate the islets and the exocrine pancreas in high numbers. CD8+ T cells are the main cell type found in the insulitic lesion, and CD8+ T cells reactive against beta cell antigens have been detected in the periphery and in the pancreas of subjects with short and long disease duration. The Diabetes Virus Detection (DiViD) study collected pancreatic tissue, by pancreatic tail resection, from living patients with recent-onset type 1 diabetes. These tissues have been extensively studied by the scientific community, but the autoreactive nature of the T cell infiltrate has remained unexplored. Our objective was to determine the number and localization of these cells in pancreas samples obtained through the DiViD study. Here, we demonstrate the presence of high frequencies of CD8+ T cells reactive against a highly relevant epitope derived from the preproinsulin signal peptide in pancreatic tissue samples from these donors. We additionally show the heterogeneity of islet distribution and CD8+ T cell infiltration. Our findings contribute to the current limited existing knowledge on T cell reactivity in the pancreas of recent onset type 1 diabetic donors, and indicate that antigen-specific therapies directed towards preproinsulin could have high clinical impact.

Inducible regulatory T cells (iTregs) from recent-onset type 1 diabetes subjects show increased in vitro suppression and higher ITCH levels compared with controls

2010 ◽  
Vol 339 (3) ◽  
pp. 585-595 ◽  
Author(s):  
Sanja Glisic ◽  
Sarah Ehlenbach ◽  
Parthav Jailwala ◽  
Jill Waukau ◽  
Srikanta Jana ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Regulatory T Cells ◽  
Recent Onset ◽  
Onset Type

scholarly journals Demonstration of Tissue Resident Memory CD8 T Cells in Insulitic Lesions in Adult Patients with Recent-Onset Type 1 Diabetes

2017 ◽  
Vol 187 (3) ◽  
pp. 581-588 ◽  
Author(s):  
Enida Kuric ◽  
Peter Seiron ◽  
Lars Krogvold ◽  
Bjørn Edwin ◽  
Trond Buanes ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Cd8 T Cells ◽  
Adult Patients ◽  
Memory Cd8 T Cells ◽  
Recent Onset ◽  
Onset Type

Precursor frequencies of T-cells reactive to insulin in recent onset type 1 diabetes mellitus

2004 ◽  
Vol 23 (1) ◽  
pp. 55-61 ◽  
Author(s):  
Ramachandra G Naik ◽  
Cora Beckers ◽  
Rino Wentwoord ◽  
Arlette Frenken ◽  
Gaby Duinkerken ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
T Cells ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Recent Onset ◽  
Onset Type

scholarly journals One in Ten CD8+ Cells in the Pancreas of Living Individuals With Recent Onset Type 1 Diabetes Recognizes the Preproinsulin Epitope PPI15-24

2021 ◽  
Author(s):  
Ada Admin ◽  
Teresa Rodriguez-Calvo ◽  
Lars Krogvold ◽  
Natalie Amirian ◽  
Knut Dahl-Jørgensen ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
T Cell ◽  
Cd8 T Cells ◽  
Pancreatic Tissue ◽  
Cell Reactivity ◽  
Tissue Samples ◽  
Recent Onset ◽  
Onset Type

In type 1 diabetes, a lifelong autoimmune disease, T cells infiltrate the islets and the exocrine pancreas in high numbers. CD8+ T cells are the main cell type found in the insulitic lesion, and CD8+ T cells reactive against beta cell antigens have been detected in the periphery and in the pancreas of subjects with short and long disease duration. The Diabetes Virus Detection (DiViD) study collected pancreatic tissue, by pancreatic tail resection, from living patients with recent-onset type 1 diabetes. These tissues have been extensively studied by the scientific community, but the autoreactive nature of the T cell infiltrate has remained unexplored. Our objective was to determine the number and localization of these cells in pancreas samples obtained through the DiViD study. Here, we demonstrate the presence of high frequencies of CD8+ T cells reactive against a highly relevant epitope derived from the preproinsulin signal peptide in pancreatic tissue samples from these donors. We additionally show the heterogeneity of islet distribution and CD8+ T cell infiltration. Our findings contribute to the current limited existing knowledge on T cell reactivity in the pancreas of recent onset type 1 diabetic donors, and indicate that antigen-specific therapies directed towards preproinsulin could have high clinical impact.

scholarly journals Decreased CD127 Expression on CD4+ T-Cells and Elevated Frequencies of CD4+CD25+CD127− T-Cells in Children with Long-Lasting Type 1 Diabetes

2013 ◽  
Vol 2013 ◽  
pp. 1-11 ◽  
Author(s):  
Marcin Moniuszko ◽  
Barbara Glowinska-Olszewska ◽  
Malgorzata Rusak ◽  
Marta Jeznach ◽  
Kamil Grubczak ◽  
...  
Keyword(s):  
T Cells ◽  
Type 1 Diabetes ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Recent Onset ◽  
Interleukin 7 ◽  
Inflammatory Parameters ◽  
Regulatory Phenotype ◽  
Cd127 Expression

Pathobiology of type 1 diabetes (T1D) is predominantly associated with T-cell-related actions. Homeostasis of majority of T-cells is critically dependent on signals mediated by CD127 (interleukin-7 receptor, IL-7R). In contrast, regulatory T-cells express very little CD127 and thereby may be delineated by CD4+CD25+CD127− phenotype. Here we aimed to analyze CD127 expression on CD4+ and CD8+ T-cells and enumerate CD4+CD25+CD127− T-cells in long-lasting T1D. T-cells were analyzed by flow cytometry and immunologic data were correlated with vascular, metabolic, and inflammatory parameters. We demonstrated significantly decreased CD127 levels on CD4+, but not CD8+, T cells in T1D pediatric patients. Interestingly, frequencies of CD4+CD25+CD127− T-cells were significantly enhanced in T1D children and correlated well with frequencies of CD34+CD144+ endothelial progenitor cells and CD4+CD25− T-cells. Levels of CD127 on both CD4+ and CD8+ T-cells in T1D patients were not correlated to each other or HbA1C. Interestingly, however, CD127 levels on CD4+ T-cells were significantly correlated to frequencies of CD4+CD25+CD127− T-cells, whereas CD127 levels on CD8+ T-cells were significantly correlated to concentrations of VEGF and triglycerides. Our data indicate that CD127 expression is differentially modulated on CD4+ and CD8+ T-cells in the course of T1D. Moreover, we demonstrated that, in contrast to recent-onset T1D, long-lasting T1D is associated with enhancement of T-cells with regulatory phenotype.

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