scholarly journals Longitudinal Associations Between Ambient Air Pollution With Insulin Sensitivity, β-Cell Function, and Adiposity in Los Angeles Latino Children

Diabetes ◽  
2017 ◽  
Vol 66 (7) ◽  
pp. 1789-1796 ◽  
Author(s):  
Tanya L. Alderete ◽  
Rima Habre ◽  
Claudia M. Toledo-Corral ◽  
Kiros Berhane ◽  
Zhanghua Chen ◽  
...  
Keyword(s):  
Air Pollution ◽  
Insulin Sensitivity ◽  
Los Angeles ◽  
Cell Function ◽  
Ambient Air ◽  
Ambient Air Pollution ◽  
Latino Children ◽  
Β Cell ◽  
Β Cell Function ◽  
Longitudinal Associations

scholarly journals The Macrophage Activation Marker Soluble CD163 is Longitudinally Associated With Insulin Sensitivity and β-cell Function

2019 ◽  
Vol 105 (3) ◽  
pp. e285-e294 ◽  
Author(s):  
Zhila Semnani-Azad ◽  
Philip W Connelly ◽  
Luke W Johnston ◽  
Ravi Retnakaran ◽  
Stewart B Harris ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Sensitivity ◽  
Cell Function ◽  
Sensitivity Index ◽  
Insulinogenic Index ◽  
Β Cell ◽  
Soluble Cd163 ◽  
Β Cell Function ◽  
Longitudinal Associations

Abstract Context Chronic inflammation arising from adipose tissue macrophage (ATM) activation may be central in type 2 diabetes etiology. Our objective was to assess the longitudinal associations of soluble CD163 (sCD163), a novel biomarker of ATM activation, with insulin sensitivity, β-cell function, and dysglycemia in high-risk subjects. Methods Adults at risk for type 2 diabetes in the Prospective Metabolism and Islet Cell Evaluation (PROMISE) study had 3 assessments over 6 years (n = 408). Levels of sCD163 were measured using fasting serum. Insulin sensitivity was assessed by HOMA2-%S and the Matsuda index (ISI). β-cell function was determined by insulinogenic index (IGI) over HOMA-IR and insulin secretion-sensitivity index-2 (ISSI-2). Incident dysglycemia was defined as the onset of impaired fasting glucose, impaired glucose tolerance, or type 2 diabetes. Generalized estimating equations (GEE) evaluated longitudinal associations of sCD163 with insulin sensitivity, β-cell function, and incident dysglycemia adjusting for demographic and lifestyle covariates. Areas under receiver-operating-characteristic curve (AROC) tested whether sCD163 improved dysglycemia prediction in a clinical model. Results Longitudinal analyses showed significant inverse associations between sCD163 and insulin sensitivity (% difference per standard deviation increase of sCD163 for HOMA2-%S (β = −7.01; 95% CI, −12.26 to −1.44) and ISI (β = −7.60; 95% CI, −11.09 to −3.97) and β-cell function (ISSI-2 (β = −4.67; 95 %CI, −8.59 to −0.58) and IGI/HOMA-IR (β = −8.75; 95% CI, −15.42 to −1.56)). Increased sCD163 was associated with greater risk for incident dysglycemia (odds ratio = 1.04; 95% CI, 1.02-1.06; P < 0.001). Adding sCD163 data to a model with clinical variables improved prediction of incident dysglycemia (AROC=0.6731 vs 0.638; P < 0.05). Conclusions sCD163 was longitudinally associated with core disorders that precede the onset of type 2 diabetes.

Liver Fat Reduction After Gastric Banding and Associations with Changes in Insulin Sensitivity and β‐Cell Function

Obesity ◽  
2021 ◽  
Author(s):  
Anny H. Xiang ◽  
Mayra P. Martinez ◽  
Enrique Trigo ◽  
Kristina M. Utzschneider ◽  
Melanie Cree‐Green ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Gastric Banding ◽  
Cell Function ◽  
Liver Fat ◽  
Β Cell ◽  
Fat Reduction ◽  
Β Cell Function

β‐cell function, incretin response, and insulin sensitivity of glucose and fat metabolism in obese youth: Relationship to OGTT‐time‐to‐glucose‐peak

2019 ◽  
Vol 21 (1) ◽  
pp. 18-27
Author(s):  
Joon Young Kim ◽  
Hala Tfayli ◽  
Fida Bacha ◽  
SoJung Lee ◽  
Sara F. Michaliszyn ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Cell Function ◽  
Fat Metabolism ◽  
Β Cell ◽  
Obese Youth ◽  
Β Cell Function

scholarly journals Adiponectin, Insulin Sensitivity, β-Cell Function, and Racial/Ethnic Disparity in Treatment Failure Rates in TODAY

Diabetes Care ◽  
2016 ◽  
Vol 40 (1) ◽  
pp. 85-93 ◽  
Author(s):  
Silva Arslanian ◽  
Laure El ghormli ◽  
Fida Bacha ◽  
Sonia Caprio ◽  
Robin Goland ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Treatment Failure ◽  
Cell Function ◽  
Ethnic Disparity ◽  
Failure Rates ◽  
Β Cell ◽  
Β Cell Function ◽  
Racial Ethnic

scholarly journals Leptin Levels, β-Cell Function, and Insulin Sensitivity in Families with Congenital and Acquired Generalized Lipoatropic Diabetes1

1998 ◽  
Vol 83 (2) ◽  
pp. 503-508
Author(s):  
Victor C. Pardini ◽  
Ivana M. N. Victória ◽  
Selma M. V. Rocha ◽  
Danielle G. Andrade ◽  
Aline M. Rocha ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Temporal Relationship ◽  
Cell Function ◽  
Model Assessment ◽  
Homeostasis Model Assessment ◽  
Β Cell ◽  
Insulin Levels ◽  
Β Cell Function ◽  
Plasma Leptin ◽  
Specific Insulin

Lipoatropic diabetes (LD) designates a group of syndromes characterized by diabetes mellitus with marked insulin resistance and either a localized or generalized absence of adipose tissue. In this study, we evaluated plasma leptin levels in subjects with congenital generalized lipoatropic diabetes (CGLD, n = 11) or acquired generalized lipoatropic diabetes (AGLD, n = 11), and assessed correlations between leptin levels and estimations of insulin secretion and insulin sensitivity using homeostasis model assessment (HOMA). Leptin levels were 0.86 ± 0.32, 1.76 ± 0.78, and 6.9 ± 4.4 ng/mL in subjects with CGLD, AGLD, and controls (n = 19), respectively (ANOVA P < 0.0001). Specific insulin levels were 154 ± 172, 177 ± 137 and 43 ± 22 pmol/L, respectively (P < 0.0001). Insulin sensitivity was significantly decreased in both groups with LD (P< 0.0001), whereas HOMA β-cell function was not significantly different when compared with controls. Leptin levels were significantly correlated with body mass index, insulin levels, and HOMA β-cell function, and inversely correlated with insulin sensitivity in control subjects but not in subjects with generalized LD. In conclusion, decreased leptin levels were observed in subjects with generalized LD, with a trend towards lower levels in the acquired than in the congenital form (P = 0.06). The temporal relationship between the decrease in leptin levels and the development of lipoatrophy should be investigated in at-risk young relatives of subjects with the acquired forms to assess the usefulness of leptin levels as a marker of lipoatrophy.

scholarly journals Distinctive postprandial modulation of β cell function and insulin sensitivity by dietary fats: monounsaturated compared with saturated fatty acids

2008 ◽  
Vol 88 (3) ◽  
pp. 638-644 ◽  
Author(s):  
Sergio López ◽  
Beatriz Bermúdez ◽  
Yolanda M Pacheco ◽  
José Villar ◽  
Rocío Abia ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Insulin Sensitivity ◽  
Cell Function ◽  
Saturated Fatty Acids ◽  
Dietary Fats ◽  
Β Cell ◽  
Β Cell Function

Simple measurements of insulin sensitivity and β-cell function

2000 ◽  
Vol 50 ◽  
pp. 68
Author(s):  
M. Albareda ◽  
J. Rodríguez-Espinosa ◽  
M. Moruño ◽  
A. de Leiva ◽  
R. Corcoy
Keyword(s):  
Insulin Sensitivity ◽  
Cell Function ◽  
Β Cell ◽  
Β Cell Function
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