A Whole-Genome RNA Interference Screen Reveals a Role forSpry2in Insulin Transcription and the Unfolded Protein Response

Zachary Pappalardo; Deeksha Gambhir Chopra; Thomas G. Hennings; Hunter Richards; Justin Choe; Katherine Yang; Luc Baeyens; Kenny Ang; Steven Chen; Michelle Arkin; Michael S. German; Michael T. McManus; Gregory M. Ku

doi:10.2337/db16-0962

A Whole-Genome RNA Interference Screen Reveals a Role forSpry2in Insulin Transcription and the Unfolded Protein Response

Diabetes ◽

10.2337/db16-0962 ◽

2017 ◽

Vol 66 (6) ◽

pp. 1703-1712 ◽

Cited By ~ 10

Author(s):

Zachary Pappalardo ◽

Deeksha Gambhir Chopra ◽

Thomas G. Hennings ◽

Hunter Richards ◽

Justin Choe ◽

...

Keyword(s):

Rna Interference ◽

Unfolded Protein Response ◽

Whole Genome ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response

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Oestrogen-driven changes in the bovine uterus are associated with activation of the unfolded protein response

Reproduction Abstracts ◽

10.1530/repabs.1.p007 ◽

2014 ◽

Author(s):

Mohammed A Alfattah ◽

Paul Anthony McGettigan ◽

John Arthur Browne ◽

Khalid M Alkhodair ◽

Katarzyna Pluta ◽

...

Keyword(s):

Unfolded Protein Response ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response

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Faculty Opinions recommendation of The unfolded protein response modulates disease severity in Pelizaeus-Merzbacher disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1007041.165807 ◽

2002 ◽

Author(s):

David Ron

Keyword(s):

Unfolded Protein Response ◽

Disease Severity ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response ◽

Pelizaeus Merzbacher Disease

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Faculty Opinions recommendation of Plasma cell differentiation and the unfolded protein response intersect at the transcription factor XBP-1.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1013206.189603 ◽

2003 ◽

Author(s):

Dan Conrad

Keyword(s):

Transcription Factor ◽

Cell Differentiation ◽

Unfolded Protein Response ◽

Plasma Cell ◽

Plasma Cell Differentiation ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response

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Faculty Opinions recommendation of Proteasome inhibitors disrupt the unfolded protein response in myeloma cells.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1015247.196201 ◽

2003 ◽

Author(s):

David Ron

Keyword(s):

Unfolded Protein Response ◽

Proteasome Inhibitors ◽

Myeloma Cells ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response

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Faculty Opinions recommendation of XBP1: a link between the unfolded protein response, lipid biosynthesis, and biogenesis of the endoplasmic reticulum.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1022175.251745 ◽

2004 ◽

Author(s):

Suresh Subramani

Keyword(s):

Endoplasmic Reticulum ◽

Unfolded Protein Response ◽

Lipid Biosynthesis ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response

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Faculty Opinions recommendation of Gcn4p and novel upstream activating sequences regulate targets of the unfolded protein response.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1022351.253712 ◽

2004 ◽

Author(s):

Richard J Maraia

Keyword(s):

Unfolded Protein Response ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response

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Faculty Opinions recommendation of Activation of the unfolded protein response is required for defenses against bacterial pore-forming toxin in vivo.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1125928.583037 ◽

2008 ◽

Author(s):

Guy Tran Van Nhieu

Keyword(s):

Unfolded Protein Response ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response

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Faculty Opinions recommendation of BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.4390977.4264054 ◽

2010 ◽

Author(s):

Davis Ng ◽

Guillaume Thibault

Keyword(s):

Er Stress ◽

Unfolded Protein Response ◽

Stress Sensor ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response

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Faculty Opinions recommendation of Accumulation of mutant alpha1-antitrypsin Z in the endoplasmic reticulum activates caspases-4 and -12, NFkappaB, and BAP31 but not the unfolded protein response.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5021.461624 ◽

2005 ◽

Author(s):

Neil Kaplowitz

Keyword(s):

Endoplasmic Reticulum ◽

Unfolded Protein Response ◽

Unfolded Protein ◽

Alpha1 Antitrypsin ◽

The Unfolded Protein Response ◽

Protein Response

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Faculty Opinions recommendation of ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein response.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.718319725.793492560 ◽

2014 ◽

Author(s):

Marian Waterman

Keyword(s):

Er Stress ◽

Unfolded Protein Response ◽

Intestinal Epithelial ◽

Rapid Loss ◽

Unfolded Protein ◽

The Unfolded Protein Response ◽

Protein Response

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