scholarly journals Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants

Diabetes ◽  
2016 ◽  
Vol 65 (12) ◽  
pp. 3805-3811 ◽  
Author(s):  
Soren K. Thomsen ◽  
Alessandro Ceroni ◽  
Martijn van de Bunt ◽  
Carla Burrows ◽  
Amy Barrett ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Functional Characterization ◽  
Diabetes Risk ◽  
Risk Variants ◽  
Causal Genes

scholarly journals No Association of Type 2 Diabetes Risk Variants and Prostate Cancer Risk: the Multiethnic Cohort and PAGE: Table 1.

2011 ◽  
Vol 20 (9) ◽  
pp. 1979-1981 ◽  
Author(s):  
Kevin M. Waters ◽  
Lynne R. Wilkens ◽  
Kristine R. Monroe ◽  
Daniel O. Stram ◽  
Laurence N. Kolonel ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Type 2 Diabetes ◽  
Cancer Risk ◽  
Prostate Cancer Risk ◽  
Diabetes Risk ◽  
Risk Variants ◽  
Multiethnic Cohort ◽  
Page Table

scholarly journals Type 2 diabetes risk variants and colorectal cancer risk: the Multiethnic Cohort and PAGE studies

Gut ◽  
2011 ◽  
Vol 60 (12) ◽  
pp. 1703-1711 ◽  
Author(s):  
I. Cheng ◽  
C. P. Caberto ◽  
A. Lum-Jones ◽  
A. Seifried ◽  
L. R. Wilkens ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Type 2 Diabetes ◽  
Cancer Risk ◽  
Diabetes Risk ◽  
Colorectal Cancer Risk ◽  
Risk Variants ◽  
Multiethnic Cohort

A replication study of 49 Type 2 diabetes risk variants in a Punjabi Pakistani population

2015 ◽  
Vol 33 (8) ◽  
pp. 1112-1117
Author(s):  
A. Zia ◽  
X. Wang ◽  
A. Bhatti ◽  
F. Y. Demirci ◽  
W. Zhao ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Risk ◽  
Replication Study ◽  
Pakistani Population ◽  
Risk Variants

scholarly journals Common Type 2 Diabetes Risk Gene Variants Associate with Gestational Diabetes

2009 ◽  
Vol 94 (1) ◽  
pp. 145-150 ◽  
Author(s):  
Jeannet Lauenborg ◽  
Niels Grarup ◽  
Peter Damm ◽  
Knut Borch-Johnsen ◽  
Torben Jørgensen ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Receiver Operating Characteristic ◽  
Operating Characteristic ◽  
Diabetes Risk ◽  
Gene Variants ◽  
Risk Alleles ◽  
Risk Variants ◽  
Receiver Operating

Abstract Objective: We aimed to examine the association between gestational diabetes mellitus (GDM) and 11 recently identified type 2 diabetes susceptibility loci. Research Design and Methods: Type 2 diabetes risk variants in TCF7L2, CDKAL1, SLC30A8, HHEX/IDE, CDKN2A/2B, IGF2BP2, FTO, TCF2, PPARG, KCNJ11, and WFS1 loci were genotyped in a cohort of women with a history of GDM (n = 283) and glucose-tolerant women of the population-based Inter99 cohort (n = 2446). Results: All the risk alleles in the 11 examined type 2 diabetes risk variants showed an odds ratio (OR) greater than 1 for the GDM group compared with the control group ranging from 1.13 [95% confidence interval (CI) 0.88–1.46] to 1.44 (95% CI 1.19–1.74) except for the WFS1 rs10010131 variant with OR 0.87 (95% CI 0.73–1.05). Combined analysis of all 11 variants showed a highly significant additive effect of multiple risk alleles on risk of GDM [OR 1.18 (95% CI 1.10–1.27)] per risk allele, P = 3.2 × 10−6). Applying receiver-operating characteristic showed an area under the receiver-operating characteristic curve of 0.62 for the genetic test alone and 0.73 when combining information on age, body mass index, and genotypes of the 11 gene variants. Conclusions: The prevalence in a prior GDM group of several previously proven type 2 diabetes risk alleles equals the findings from association studies on type 2 diabetes. This supports the hypothesis that GDM and type 2 diabetes are two of the same entity.

scholarly journals Evaluation of Common Type 2 Diabetes Risk Variants in a South Asian Population of Sri Lankan Descent

PLoS ONE ◽  
2014 ◽  
Vol 9 (6) ◽  
pp. e98608 ◽  
Author(s):  
Neelam Hassanali ◽  
N. Maneka G. De Silva ◽  
Neil Robertson ◽  
N. William Rayner ◽  
Amy Barrett ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
South Asian ◽  
Asian Population ◽  
Common Type ◽  
Diabetes Risk ◽  
Sri Lankan ◽  
South Asian Population ◽  
Risk Variants

scholarly journals Prioritising Causal Genes at Type 2 Diabetes Risk Loci

2017 ◽  
Vol 17 (9) ◽  
Author(s):  
Antje K. Grotz ◽  
Anna L. Gloyn ◽  
Soren K. Thomsen
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Risk ◽  
Causal Genes

Functional characterization of the type 2 diabetes associated variant rs3832490 in repin1

2013 ◽  
Vol 8 (S 01) ◽  
Author(s):  
J Krüger ◽  
K Weidle ◽  
M Kern ◽  
B Enigk ◽  
M Prellberg ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Functional Characterization

scholarly journals A genetic risk score that includes common type 2 diabetes risk variants is associated with gestational diabetes

2017 ◽  
Vol 87 (2) ◽  
pp. 149-155 ◽  
Author(s):  
V. K. Kawai ◽  
R. T. Levinson ◽  
A. Adefurin ◽  
D. Kurnik ◽  
S. P. Collier ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Gestational Diabetes ◽  
Risk Score ◽  
Genetic Risk ◽  
Genetic Risk Score ◽  
Common Type ◽  
Diabetes Risk ◽  
Risk Variants

scholarly journals Consistent Directions of Effect for Established Type 2 Diabetes Risk Variants Across Populations: The Population Architecture using Genomics and Epidemiology (PAGE) Consortium

Diabetes ◽  
2012 ◽  
Vol 61 (6) ◽  
pp. 1642-1647 ◽  
Author(s):  
C. A. Haiman ◽  
M. D. Fesinmeyer ◽  
K. L. Spencer ◽  
P. Buzkova ◽  
V. S. Voruganti ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Diabetes Risk ◽  
Risk Variants
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