scholarly journals Endothelial Fcγ Receptor IIB Activation Blunts Insulin Delivery to Skeletal Muscle to Cause Insulin Resistance in Mice

Diabetes ◽  
2016 ◽  
Vol 65 (7) ◽  
pp. 1996-2005 ◽  
Author(s):  
Keiji Tanigaki ◽  
Ken L. Chambliss ◽  
Ivan S. Yuhanna ◽  
Anastasia Sacharidou ◽  
Mohamed Ahmed ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Insulin Delivery ◽  
Fcγ Receptor

scholarly journals Endothelial Transcytosis of Insulin: Does It Contribute to Insulin Resistance?

Physiology ◽  
2016 ◽  
Vol 31 (5) ◽  
pp. 336-345 ◽  
Author(s):  
Warren L. Lee ◽  
Amira Klip
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Insulin Delivery ◽  
Capillary Endothelium ◽  
Second Stage

Most research on insulin resistance has focused on impaired signaling at the level of target tissues like skeletal muscle. Insulin delivery is also important and includes recruitment and perfusion of capillaries bearing insulin, but also the transit of insulin across the capillary endothelium. The mechanisms of this second stage (insulin transcytosis) and whether it contributes to insulin resistance remain uncertain.

scholarly journals Rapid changes in the microvascular circulation of skeletal muscle impair insulin delivery during sepsis

2019 ◽  
Vol 316 (6) ◽  
pp. E1012-E1023 ◽  
Author(s):  
Nicholas A. Mignemi ◽  
P. Mason McClatchey ◽  
Kameron V. Kilchrist ◽  
Ian M. Williams ◽  
Bryan A. Millis ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Blood Flow ◽  
Capillary Flow ◽  
Insulin Delivery ◽  
Microvascular Blood Flow ◽  
Early Event ◽  
Rapid Reduction ◽  
Arterial Blood ◽  
Skeletal Muscle Microcirculation

Sepsis costs the healthcare system $23 billion annually and has a mortality rate between 10 and 40%. An early indication of sepsis is the onset of hyperglycemia, which is the result of sepsis-induced insulin resistance in skeletal muscle. Previous investigations have focused on events in the myocyte (e.g., insulin signaling and glucose transport and subsequent metabolism) as the causes for this insulin-resistant state. However, the delivery of insulin to the skeletal muscle is also an important determinant of insulin action. Skeletal muscle microvascular blood flow, which delivers the insulin to the muscle, is known to be decreased during sepsis. Here we test whether the reduced capillary blood flow to skeletal muscle belies the sepsis-induced insulin resistance by reducing insulin delivery to the myocyte. We hypothesize that decreased capillary flow and consequent decrease in insulin delivery is an early event that precedes gross cardiovascular alterations seen with sepsis. This hypothesis was examined in mice treated with either lipopolysaccharide (LPS) or polymicrobial sepsis followed by intravital microscopy of the skeletal muscle microcirculation. We calculated insulin delivery to the myocyte using two independent methods and found that LPS and sepsis rapidly reduce insulin delivery to the skeletal muscle by ~50%; this was driven by decreases in capillary flow velocity and the number of perfused capillaries. Furthermore, the changes in skeletal muscle microcirculation occur before changes in both cardiac output and arterial blood pressure. These data suggest that a rapid reduction in skeletal muscle insulin delivery contributes to the induction of insulin resistance during sepsis.

Extracts of Hymenocardia acida ameliorate insulin resistance in skeletal muscle cells

Planta Medica ◽  
2016 ◽  
Vol 81 (S 01) ◽  
pp. S1-S381
Author(s):  
II Ezeigbo ◽  
C Wheeler-Jones ◽  
S Gibbons ◽  
ME Cleasby
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Muscle Cells ◽  
Skeletal Muscle Cells ◽  
Ameliorate Insulin Resistance

IRAK-1/IRS-1 Signaling Cross Talk in Human Skeletal Muscle—Role in Insulin Resistance

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 159-OR
Author(s):  
THEODORE P. CIARALDI ◽  
SUNDER MUDALIAR ◽  
LIWU LI ◽  
ROSARIO SCALIA ◽  
XIAO JIAN SUN ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Cross Talk ◽  
Human Skeletal Muscle

1931-P: Skeletal Muscle (SM) Insulin Resistance (IR) in Coronary Artery Disease (CAD) in Type 1 Diabetes (T1D)

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1931-P
Author(s):  
KATHERINE V. WILLIAMS ◽  
CHRISTINA M. SHAY ◽  
JULIE PRICE ◽  
TREVOR J. ORCHARD ◽  
DAVID KELLEY
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Coronary Artery Disease ◽  
Type 1 Diabetes ◽  
Coronary Artery ◽  
Artery Disease

1891-P: Palmitate-Enriched Lipid Ingestion Acutely Induces Insulin Resistance Associated with PKCγ Activation and Impaired Mitochondrial Function in Human Skeletal Muscle

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1891-P
Author(s):  
THERESIA SARABHAI ◽  
CHRYSI KOLIAKI ◽  
SABINE KAHL ◽  
DOMINIK PESTA ◽  
LUCIA MASTROTOTARO ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Mitochondrial Function ◽  
Human Skeletal Muscle

Indirect effect of catecholamines on development of insulin resistance in skeletal muscle from diabetic rats

Diabetes ◽  
1989 ◽  
Vol 38 (7) ◽  
pp. 906-910 ◽  
Author(s):  
M. Bostrom ◽  
Z. Nie ◽  
G. Goertz ◽  
J. Henriksson ◽  
H. Wallberg-Henriksson
Keyword(s):  
Insulin Resistance ◽  
Skeletal Muscle ◽  
Indirect Effect ◽  
Diabetic Rats
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