scholarly journals Adipose Cell Size and Regional Fat Deposition as Predictors of Metabolic Response to Overfeeding in Insulin-Resistant and Insulin-Sensitive Humans

Diabetes ◽  
2016 ◽  
Vol 65 (5) ◽  
pp. 1245-1254 ◽  
Author(s):  
Tracey McLaughlin ◽  
Colleen Craig ◽  
Li-Fen Liu ◽  
Dalia Perelman ◽  
Candice Allister ◽  
...  
Keyword(s):  
Cell Size ◽  
Metabolic Response ◽  
Fat Deposition ◽  
Adipose Cell ◽  
Insulin Resistant ◽  
Adipose Cell Size

Adipose cell size-function relationships: insulin binding and degradation

1981 ◽  
Vol 240 (2) ◽  
pp. E166-E174
Author(s):  
S. W. Cushman ◽  
D. Noda ◽  
L. B. Salans
Keyword(s):  
Steady State ◽  
Cell Size ◽  
Plasma Insulin ◽  
Metabolic Response ◽  
Biological Response ◽  
Insulin Binding ◽  
Small Degree ◽  
Adipose Cell ◽  
Adipose Cell Size ◽  
Adipose Cells

125I-insulin binding and degradation have been studied in isolated rat adipose cells of increasing size. Binding at 24 degrees C reaches a steady state by 40-60 min in the absence of significant degradation. At 37 degrees C, binding reaches only a transient maximum by 10-15 min because insulin is rapidly degraded. Cellular enlargement is associated with increasing steady-state binding per cell at 24 degrees C, and increasing maximum binding and degradation per cell at 37 degrees C, in spite of increasing plasma insulin concentrations in the rats from which cells were prepared. Detailed steady-state studies at 24 degrees C, however, fail to delineate the mechanism of these alterations. Although dissociation experiments are consistent with the presence of a small degree of negatively cooperative binding site interaction, its magnitude is unchanged with increasing cell size. Furthermore, binding levels per unit cellular surface at 24 degrees C, at least at those insulin concentrations eliciting a biological response, remain relatively constant. None of the alterations in insulin binding observed here can explain the enlarged adipose cell's markedly decreased metabolic response to insulin.

ADIPOSE-CELL SIZE AND IMMUNOREACTIVE INSULIN LEVELS IN OBESE AND NORMAL-WEIGHT ADULTS

The Lancet ◽  
1972 ◽  
Vol 300 (7784) ◽  
pp. 948-951 ◽  
Author(s):  
JudithS. Stern ◽  
Nina Hollander ◽  
BruceR. Batchelor ◽  
CalK. Cohn ◽  
Jules Hirsch
Keyword(s):  
Cell Size ◽  
Normal Weight ◽  
Immunoreactive Insulin ◽  
Adipose Cell ◽  
Insulin Levels ◽  
Adipose Cell Size

scholarly journals Amelioration of insulin resistance by rosiglitazone is associated with increased adipose cell size in obese type 2 diabetics

2012 ◽  
Vol 26 (S1) ◽  
Author(s):  
Jian Yang ◽  
Bjorn Eliasson ◽  
Ulf Smith ◽  
Samuel W. Cushman ◽  
Arthur Sherman
Keyword(s):  
Insulin Resistance ◽  
Cell Size ◽  
Adipose Cell ◽  
Type 2 Diabetics ◽  
Adipose Cell Size

scholarly journals Amelioration of insulin resistance by rosiglitazone is associated with increased adipose cell size in obese type 2 diabetic patients

Adipocyte ◽  
2014 ◽  
Vol 3 (4) ◽  
pp. 314-321 ◽  
Author(s):  
Bjorn Eliasson ◽  
Ulf Smith ◽  
Shawn Mullen ◽  
Samuel W Cushman ◽  
Arthur S Sherman ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cell Size ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Adipose Cell ◽  
Adipose Cell Size ◽  
Type 2 Diabetic

Adipose cell size in spontaneously hypertensive rats (SHR)

1979 ◽  
Vol 33 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Peter Singer ◽  
Siegfried Voigt ◽  
Vera Moritz ◽  
Rudolf Baumann
Keyword(s):  
Cell Size ◽  
Spontaneously Hypertensive Rats ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive ◽  
Adipose Cell ◽  
Adipose Cell Size

scholarly journals Adipose cell size and number in obese children.

1970 ◽  
Vol 45 (244) ◽  
pp. 819-819 ◽  
Author(s):  
C G Brook ◽  
J K Lloyd
Keyword(s):  
Cell Size ◽  
Obese Children ◽  
Adipose Cell ◽  
Adipose Cell Size

Deletion of the Angiotensin Type 2 Receptor (AT2R) Reduces Adipose Cell Size and Protects From Diet-Induced Obesity and Insulin Resistance

Diabetes ◽  
2005 ◽  
Vol 54 (4) ◽  
pp. 991-999 ◽  
Author(s):  
L. Yvan-Charvet ◽  
P. Even ◽  
M. Bloch-Faure ◽  
M. Guerre-Millo ◽  
N. Moustaid-Moussa ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Cell Size ◽  
Adipose Cell ◽  
Diet Induced Obesity ◽  
Angiotensin Type 2 Receptor ◽  
Adipose Cell Size ◽  
Angiotensin Type
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