scholarly journals Role of PKCδ in Insulin Sensitivity and Skeletal Muscle Metabolism

Diabetes ◽  
2015 ◽  
Vol 64 (12) ◽  
pp. 4023-4032 ◽  
Author(s):  
Mengyao Li ◽  
Sara G. Vienberg ◽  
Olivier Bezy ◽  
Brian T. O’Neill ◽  
C. Ronald Kahn
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Muscle Metabolism ◽  
Skeletal Muscle Metabolism

Emerging role of neuregulin as a modulator of muscle metabolism

2010 ◽  
Vol 298 (4) ◽  
pp. E742-E750 ◽  
Author(s):  
Anna Gumà ◽  
Vicente Martínez-Redondo ◽  
Iliana López-Soldado ◽  
Carles Cantó ◽  
Antonio Zorzano
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Neuromuscular Junction ◽  
Muscle Contraction ◽  
Neurotrophic Factor ◽  
Muscle Metabolism ◽  
Metabolic Effects ◽  
Energetic Metabolism ◽  
Insulin Responsiveness

Neuregulin was described initially as a neurotrophic factor involved in the formation of the neuromuscular junction in skeletal muscle. However, in recent years, neuregulin has been reported to be a myokine that exerts relevant effects on myogenesis and the regulation of muscle metabolism. In this new context, the rapid and chronic metabolic effects of neuregulin appear to be related to muscle contraction. Indeed, the effects of neuregulin resemble those of exercise, which are accompanied by an improvement in insulin sensitivity. In this review, we challenge the classical role assigned to neuregulin in muscle and propound the emerging concept of its involvement in the regulation of energetic metabolism and insulin responsiveness.

scholarly journals The role of lactate in sepsis and COVID‐19: Perspective from contracting skeletal muscle metabolism

2021 ◽  
Author(s):  
U. W. Iepsen ◽  
R. R. Plovsing ◽  
K. Tjelle ◽  
N. B. Foss ◽  
C. S. Meyhoff ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Metabolism ◽  
Skeletal Muscle Metabolism

Role of Pro-inflammatory Cytokines in Regulation of Skeletal Muscle Metabolism: A Systematic Review

2020 ◽  
Vol 27 (13) ◽  
pp. 2161-2188 ◽  
Author(s):  
Bhawana Sharma ◽  
Rajesh Dabur
Keyword(s):  
Skeletal Muscle ◽  
Inflammatory Cytokines ◽  
Proinflammatory Cytokines ◽  
Skeletal Muscles ◽  
Muscle Wasting ◽  
Muscular Atrophy ◽  
Muscle Metabolism ◽  
Skeletal Muscle Metabolism ◽  
Pro Inflammatory Cytokines

Background: Metabolic pathways perturbations lead to skeletal muscular atrophy in the cachexia and sarcopenia due to increased catabolism. Pro-inflammatory cytokines induce the catabolic pathways that impair the muscle integrity and function. Hence, this review primarily concentrates on the effects of pro-inflammatory cytokines in regulation of skeletal muscle metabolism. Objective: This review will discuss the role of pro-inflammatory cytokines in skeletal muscles during muscle wasting conditions. Moreover, the coordination among the pro-inflammatory cytokines and their regulated molecular signaling pathways which increase the protein degradation will be discussed. Results: During normal conditions, pro-inflammatory cytokines are required to balance anabolism and catabolism and to maintain normal myogenesis process. However, during muscle wasting their enhanced expression leads to marked destructive metabolism in the skeletal muscles. Proinflammatory cytokines primarily exert their effects by increasing the expression of calpains and E3 ligases as well as of Nf-κB, required for protein breakdown and local inflammation. Proinflammatory cytokines also locally suppress the IGF-1and insulin functions, hence increase the FoxO activation and decrease the Akt function, the central point of carbohydrates lipid and protein metabolism. Conclusion: Current advancements have revealed that the muscle mass loss during skeletal muscular atrophy is multifactorial. Despite great efforts, not even a single FDA approved drug is available in the market. It indicates the well-organized coordination among the pro-inflammatory cytokines that need to be further understood and explored.

Role of mTOR in the regulation of skeletal muscle metabolism

2014 ◽  
Vol 40 (5) ◽  
pp. 580-588 ◽  
Author(s):  
N. D. Golberg ◽  
A. M. Druzhevskaya ◽  
V. A. Rogozkin ◽  
I. I. Ahmetov
Keyword(s):  
Skeletal Muscle ◽  
Muscle Metabolism ◽  
Skeletal Muscle Metabolism

The metabolic syndrome: Role of skeletal muscle metabolism

2006 ◽  
Vol 38 (6) ◽  
pp. 389-402 ◽  
Author(s):  
Craig S. Stump ◽  
Erik J. Henriksen ◽  
Yongzhong Wei ◽  
James R. Sowers
Keyword(s):  
Skeletal Muscle ◽  
Metabolic Syndrome ◽  
Muscle Metabolism ◽  
Skeletal Muscle Metabolism ◽  
The Metabolic Syndrome
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