scholarly journals GLP-1R Agonists Modulate Enteric Immune Responses Through the Intestinal Intraepithelial Lymphocyte GLP-1R

Diabetes ◽  
2015 ◽  
Vol 64 (7) ◽  
pp. 2537-2549 ◽  
Author(s):  
Bernardo Yusta ◽  
Laurie L. Baggio ◽  
Jacqueline Koehler ◽  
Dianne Holland ◽  
Xiemin Cao ◽  
...  
Keyword(s):  
Immune Responses ◽  
Intraepithelial Lymphocyte ◽  
Intestinal Intraepithelial Lymphocyte

scholarly journals Osteopontin and iCD8α cells promote intestinal intraepithelial lymphocyte homeostasis

2019 ◽  
Author(s):  
Ali Nazmi ◽  
Michael J. Greer ◽  
Kristen L. Hoek ◽  
M. Blanca Piazuelo ◽  
Joern-Hendrik Weitkamp ◽  
...  
Keyword(s):  
Immune Responses ◽  
Intestinal Inflammation ◽  
Intraepithelial Lymphocytes ◽  
Intestinal Lumen ◽  
Anatomical Location ◽  
List Type ◽  
Intestinal Intraepithelial Lymphocyte ◽  
Critical Components ◽  
Cellular Immune

AbstractIntestinal intraepithelial lymphocytes (IEL) comprise a diverse population of cells residing in the epithelium at the interface between the intestinal lumen and the sterile environment of the lamina propria. Because of this anatomical location, IEL are considered critical components of intestinal immune responses. Indeed, IEL are involved in many different immunological processes ranging from pathogen control to tissue stability. However, despite their critical importance in mucosal immune responses, very little is known about the homeostasis of different IEL subpopulations. The phosphoprotein osteopontin is important for critical physiological processes, including cellular immune responses such as survival of Th17 cells and homeostasis of NK cells, among others. Because of its impact in the immune system, we investigated the role of osteopontin in the homeostasis of IEL. Here, we report that mice deficient in the expression of osteopontin exhibit reduced numbers of the IEL subpopulations TCRγδ+, TCRβ+CD4+, TCRβ+CD4+CD8α+and TCRβ+CD8αα+cells in comparison to wild-type mice. For some IEL subpopulations the decrease in cells numbers could be attributed to apoptosis and reduced cell division. Moreover, we showin vitrothat exogenous osteopontin stimulates the survival of murine IEL subpopulations and unfractionated IEL derived from human intestines, an effect mediated by CD44, a known osteopontin receptor. We also show that iCD8α IEL, but not TCRγδ+IEL, TCRβ+IEL or intestinal epithelial cells, can promote survival of different IEL populations via osteopontin, indicating an important role for iCD8α cells in the homeostasis of IEL.Key PointsOsteopontin promotes homeostasis of mouse and human IEL, mediated by its ligand CD44iCD8α cells produce osteopontin which impacts the survival of other IELLack of osteopontin renders mice susceptible to intestinal inflammation

scholarly journals Intestinal Intraepithelial Lymphocyte-Enterocyte Crosstalk Regulates Production of Bactericidal Angiogenin 4 by Paneth Cells upon Microbial Challenge

PLoS ONE ◽  
2013 ◽  
Vol 8 (12) ◽  
pp. e84553 ◽  
Author(s):  
Catherine R. Walker ◽  
Isabelle Hautefort ◽  
Jane E. Dalton ◽  
Karin Overweg ◽  
Charlotte E. Egan ◽  
...  
Keyword(s):  
Paneth Cells ◽  
Intraepithelial Lymphocyte ◽  
Intestinal Intraepithelial Lymphocyte ◽  
Microbial Challenge
Sign in / Sign up

Export Citation Format

Share Document