scholarly journals Salt-Inducible Kinase 1 Terminates cAMP Signaling by an Evolutionarily Conserved Negative-Feedback Loop in β-Cells

Diabetes ◽  
2015 ◽  
Vol 64 (9) ◽  
pp. 3189-3202 ◽  
Author(s):  
Min-Jung Kim ◽  
Su-Kyung Park ◽  
Ji-Hyun Lee ◽  
Chang-Yun Jung ◽  
Dong Jun Sung ◽  
...  
Keyword(s):  
Negative Feedback ◽  
Feedback Loop ◽  
Camp Signaling ◽  
Negative Feedback Loop ◽  
Β Cells ◽  
Evolutionarily Conserved

scholarly journals Smad2/3 Activation Regulates Smad1/5/8 Signaling via a Negative Feedback Loop to Inhibit 3T3-L1 Adipogenesis

2021 ◽  
Vol 22 (16) ◽  
pp. 8472
Author(s):  
Senem Aykul ◽  
Jordan Maust ◽  
Vijayalakshmi Thamilselvan ◽  
Monique Floer ◽  
Erik Martinez-Hackert
Keyword(s):  
Negative Feedback ◽  
Feedback Loop ◽  
Negative Feedback Loop ◽  
Adipose Tissues ◽  
Family Growth ◽  
Simultaneous Activation ◽  
Adipocyte Hypertrophy ◽  
Adipocyte Development ◽  
Energy Surplus

Adipose tissues (AT) expand in response to energy surplus through adipocyte hypertrophy and hyperplasia. The latter, also known as adipogenesis, is a process by which multipotent precursors differentiate to form mature adipocytes. This process is directed by developmental cues that include members of the TGF-β family. Our goal here was to elucidate, using the 3T3-L1 adipogenesis model, how TGF-β family growth factors and inhibitors regulate adipocyte development. We show that ligands of the Activin and TGF-β families, several ligand traps, and the SMAD1/5/8 signaling inhibitor LDN-193189 profoundly suppressed 3T3-L1 adipogenesis. Strikingly, anti-adipogenic traps and ligands engaged the same mechanism of action involving the simultaneous activation of SMAD2/3 and inhibition of SMAD1/5/8 signaling. This effect was rescued by the SMAD2/3 signaling inhibitor SB-431542. By contrast, although LDN-193189 also suppressed SMAD1/5/8 signaling and adipogenesis, its effect could not be rescued by SB-431542. Collectively, these findings reveal the fundamental role of SMAD1/5/8 for 3T3-L1 adipogenesis, and potentially identify a negative feedback loop that links SMAD2/3 activation with SMAD1/5/8 inhibition in adipogenic precursors.

scholarly journals HIC1 and miR-23~27~24 clusters form a double-negative feedback loop in breast cancer

2016 ◽  
Vol 24 (3) ◽  
pp. 421-432 ◽  
Author(s):  
Yanbo Wang ◽  
Hongwei Liang ◽  
Geyu Zhou ◽  
Xiuting Hu ◽  
Zhengya Liu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Negative Feedback ◽  
Feedback Loop ◽  
Negative Feedback Loop ◽  
Double Negative

scholarly journals An Actomyosin-Arf-GEF Negative Feedback Loop for Tissue Elongation under Stress

2017 ◽  
Vol 27 (15) ◽  
pp. 2260-2270.e5 ◽  
Author(s):  
Junior J. West ◽  
Teresa Zulueta-Coarasa ◽  
Janna A. Maier ◽  
Donghoon M. Lee ◽  
Ashley E.E. Bruce ◽  
...  
Keyword(s):  
Negative Feedback ◽  
Feedback Loop ◽  
Negative Feedback Loop

THE NATURE OF DEPRESSIVE RUMINATION AND ITS CONNECTION WITH DEPRESSIVE SYMPTOMS

2020 ◽  
Vol 39 (9) ◽  
pp. 761-787
Author(s):  
Marta M. Maslej ◽  
Benoit H. Mulsant ◽  
Paul W. Andrews
Keyword(s):  
Factor Analysis ◽  
Depressive Symptoms ◽  
Problem Solving ◽  
Beck Depression Inventory ◽  
Negative Feedback ◽  
Dynamic Process ◽  
Feedback Loop ◽  
Negative Feedback Loop ◽  
Depressive Rumination ◽  
Joint Factor Analysis

Introduction: Researchers have proposed several theories of depressive rumination. To compare among them, we conducted a joint factor analysis. Methods: An online sample (n = 498) completed four rumination questionnaires and the Beck Depression Inventory. We examined associations between emerging factors and depressive symptoms. Results: Most commonly, people ruminated about solving problems in their lives, followed by the causes or consequences of negative situations. They least commonly ruminated about their symptoms and sadness. Thoughts about symptoms and causes or consequences of negative situations uniquely related to depressive symptoms. There was a circular covariance relation between depressive symptoms, thoughts about causes or consequences, and problem-solving, suggesting that symptoms are regulated by a negative feedback loop involving problem-solving. This feedback was not present unless models included thoughts about causes or consequences, suggesting that these thoughts benefit problem-solving. Discussion: Depressive rumination may be a dynamic process involving various thoughts, with different combinations of thoughts having different consequences for depression.

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