scholarly journals Increased Interaction With Insulin Receptor Substrate 1, a Novel Abnormality in Insulin Resistance and Type 2 Diabetes

Diabetes ◽  
2014 ◽  
Vol 63 (6) ◽  
pp. 1933-1947 ◽  
Author(s):  
Michael Caruso ◽  
Danjun Ma ◽  
Zaher Msallaty ◽  
Monique Lewis ◽  
Berhane Seyoum ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Insulin Receptor ◽  
Insulin Receptor Substrate ◽  
Insulin Receptor Substrate 1

Echinops Spp. Polysaccharide B Ameliorates Metabolic Abnormalities in a Rat Model of Type 2 Diabetes Mellitus

2020 ◽  
Vol 19 (1) ◽  
pp. 106-114
Author(s):  
Guang Hao ◽  
Xiaoyu Ma ◽  
Mengru Jiang ◽  
Zhenzhen Gao ◽  
Ying Yang
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Secretion ◽  
Insulin Receptor ◽  
Skeletal Muscles ◽  
Insulin Receptor Substrate ◽  
Sprague Dawley

This study examined the in vivo effects of Echinops spp. polysaccharide B on type 2 diabetes mellitus in Sprague-Dawley rats. We constructed a type 2 diabetes mellitus Sprague-Dawley rat models by feeding a high-fat and high-sugar diet plus intraperitoneal injection of a small dose of streptozotocin. Using this diabetic rat model, different doses of Echinops polysaccharide B were administered orally for seven weeks. Groups receiving Xiaoke pill and metformin served as positive controls. The results showed that Echinops polysaccharide B treatment normalized the weight and blood sugar levels in the type 2 diabetes mellitus rats, increased muscle and liver glycogen content, improved glucose tolerance, increased insulin secretion, and reduced glucagon and insulin resistance indices. More importantly, Echinops polysaccharide B treatment upregulated the expression of insulin receptor in the liver, skeletal muscles, and pancreas, and significantly improved the expression levels of insulin receptor substrate-2 protein in the liver and pancreas, as well as it increased insulin receptor substrate-1 expression in skeletal muscles. These two proteins play crucial roles in increasing insulin secretion and in controlling type 2 diabetes mellitus. The findings of the present study suggest that Echinops polysaccharide B could improve the status of diabetes in type 2 diabetes mellitus rats, which may be achieved by improving insulin resistance. Our study provides a new insight into the development of a natural drug for the control of type 2 diabetes mellitus.

scholarly journals MicroRNA 144 Impairs Insulin Signaling by Inhibiting the Expression of Insulin Receptor Substrate 1 in Type 2 Diabetes Mellitus

PLoS ONE ◽  
2011 ◽  
Vol 6 (8) ◽  
pp. e22839 ◽  
Author(s):  
Dwi Setyowati Karolina ◽  
Arunmozhiarasi Armugam ◽  
Subramaniam Tavintharan ◽  
Michael T. K. Wong ◽  
Su Chi Lim ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Receptor ◽  
Insulin Signaling ◽  
Insulin Receptor Substrate ◽  
Insulin Receptor Substrate 1

scholarly journals Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes

Diabetologia ◽  
2007 ◽  
Vol 50 (6) ◽  
pp. 1209-1217 ◽  
Author(s):  
J. C. Florez ◽  
M. Sjögren ◽  
C. M. Agapakis ◽  
N. P. Burtt ◽  
P. Almgren ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Receptor ◽  
Insulin Receptor Substrate ◽  
Common Variants ◽  
Insulin Receptor Substrate 1 ◽  
Association Testing

scholarly journals Relationship Between Insulin-Receptor Substrate 1 and Langerhans’ Islet in a Rat Model of Type 2 Diabetes Mellitus

In Vivo ◽  
2021 ◽  
Vol 35 (1) ◽  
pp. 291-297
Author(s):  
WAHYUNI LUKITA ATMODJO ◽  
YOUNG OTHIWI LARASATI ◽  
JUANDY JO ◽  
RISKA NUFIKA ◽  
STEFFI NAOMI ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Insulin Receptor ◽  
Rat Model ◽  
Insulin Receptor Substrate ◽  
Insulin Receptor Substrate 1
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