scholarly journals Going With the Flow: Adaptation of  -Cell Function to Glucose Fluxes After Bariatric Surgery

Diabetes ◽  
2013 ◽  
Vol 62 (11) ◽  
pp. 3671-3673 ◽  
Author(s):  
M. Salehi ◽  
D. A. D'Alessio
Keyword(s):  
Bariatric Surgery ◽  
Cell Function ◽  
Flow Adaptation

Bases conceptuales de la cirugía metabólica

2021 ◽  
Vol 64 (3) ◽  
pp. 6-19
Author(s):  
Juan Carlos Arana Reyes ◽  
Fernando Cerón Rodríguez ◽  
Juan Javier Díaz Rodríguez ◽  
Raúl Vázquez Pelcastre ◽  
Rodolfo Aparicio Ponce ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Cell Function ◽  
Glycosylated Hemoglobin ◽  
Insulin Resistance Syndrome ◽  
Mini Gastric Bypass ◽  
Lifestyle Modifications ◽  
Nutrition Survey ◽  
Health And Nutrition ◽  
Quitting Smoking

The term Metabolic Syndrome (MS) has been used since its introduction in 2001 by the National Cholesterol Program (NCEP: ATP III). The concept has been discussed in the scientific literature for decades. The X Syndrome and other terms such as "death quartet" and insulin resistance syndrome have been used to describe the association between metabolic and cardiovascular risk factors. In Mexico, the prevalence of MS in the National Health and Nutrition Survey (Encuesta Nacional de Salud y Nutrición, ENSANUT) was 34% in 2000 and 41% in 2012. Lifestyle modifications along with increased physical activity, quitting smoking, and limiting alcohol consumption are essential for management and prevention because they play a central role in metabolic abnormalities. However, despite the large amount of medications available for diabetes, up to 50% of patients have been reported to fail to achieve adequate control goals, as defined by the American Diabetes Association (glycosylated hemoglobin <7%). In contrast, bariatric surgery (BS) has clearly confirmed that it contributes to improved beta cell function in patients with BMI > 35 kg / m 2 , as well as control of dyslipidemia and other metabolic disorders. Keywords: Metabolic surgery; surgery and metabolic syndrome; syndrome X; mini gastric bypass; bypass of an anastomosis; Roux-en-Y bypass; bariatric surgery.

Medical Management of Endocrine Disorders after Bariatric Surgery

2018 ◽  
Author(s):  
Sangeeta Kashyap
Keyword(s):  
Bariatric Surgery ◽  
Weight Loss ◽  
Cell Function ◽  
Pancreatic Beta Cell ◽  
Sglt2 Inhibitor ◽  
Treatment Strategies ◽  
Glucose Absorption ◽  
Hyperinsulinemic Hypoglycemia ◽  
Endocrine Disorders ◽  
High Fiber

Endocrine complications after bariatric surgery include persistent hyperglycemia in patients with type 2 diabetes who experience initial success with weight loss. This complication occurs in those with a prolonged duration of diabetes (> 8 years) and is related to poor residual pancreatic beta-cell function. Often, weight regain is associated with recurrent diabetes, and strategies that target both weight loss and glycemic control are required. New diabetes agents, such as the SGLT2 inhibitor drug class, offer advantages to diabetes treatment after bariatric surgery. On the other end of the glycemic spectrum, hyperinsulinemic hypoglycemia occurs in patients with and without diabetes prior to surgery and often presents with little or no symptoms (i.e., neuroglycopenia). Treatment strategies involve careful monitoring of blood glucose levels and the use of low-glycemic/high-fiber diets as well as drugs that lower glucose absorption and insulin secretion. Glycemic management after bariatric surgery requires close observation.

Preoperative Beta Cell Function Is Predictive of Diabetes Remission After Bariatric Surgery

2016 ◽  
Vol 27 (2) ◽  
pp. 288-294 ◽  
Author(s):  
Pedro Souteiro ◽  
Sandra Belo ◽  
João Sérgio Neves ◽  
Daniela Magalhães ◽  
Rita Bettencourt Silva ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Diabetes Remission

scholarly journals Long-Term Effects of Bariatric Surgery on Meal Disposal and  -Cell Function in Diabetic and Nondiabetic Patients

Diabetes ◽  
2013 ◽  
Vol 62 (11) ◽  
pp. 3709-3717 ◽  
Author(s):  
S. Camastra ◽  
E. Muscelli ◽  
A. Gastaldelli ◽  
J. J. Holst ◽  
B. Astiarraga ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Cell Function ◽  
Long Term Effects

scholarly journals Intravital imaging of islet Ca2+ dynamics reveals enhanced β cell connectivity after bariatric surgery in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Elina Akalestou ◽  
Kinga Suba ◽  
Livia Lopez-Noriega ◽  
Eleni Georgiadou ◽  
Pauline Chabosseau ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Clinical Utility ◽  
Cell Function ◽  
Diabetes Remission ◽  
Vertical Sleeve Gastrectomy ◽  
Β Cell ◽  
Β Cell Function ◽  
Time Courses ◽  
The Impact

AbstractBariatric surgery improves both insulin sensitivity and secretion and can induce diabetes remission. However, the mechanisms and time courses of these changes, particularly the impact on β cell function, are difficult to monitor directly. In this study, we investigated the effect of Vertical Sleeve Gastrectomy (VSG) on β cell function in vivo by imaging Ca2+ dynamics in islets engrafted into the anterior eye chamber. Mirroring its clinical utility, VSG in mice results in significantly improved glucose tolerance, and enhanced insulin secretion. We reveal that these benefits are underpinned by augmented β cell function and coordinated activity across the islet. These effects involve changes in circulating GLP-1 levels which may act both directly and indirectly on the β cell, in the latter case through changes in body weight. Thus, bariatric surgery leads to time-dependent increases in β cell function and intra-islet connectivity which are likely to contribute to diabetes remission.

scholarly journals Is Insulin Resistance at Baseline a Predictor of Weight Loss After Bariatric Surgery?

2021 ◽  
Vol 5 (Supplement_1) ◽  
pp. A18-A19
Author(s):  
Marta Borges-Canha ◽  
João Sérgio Neves ◽  
Fernando Mendonça ◽  
Maria Manuel Silva ◽  
Cláudia Costa ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Weight Loss ◽  
Cell Function ◽  
First Year ◽  
Model Assessment ◽  
Post Surgery ◽  
Homeostatic Model Assessment ◽  
Homeostatic Model

Abstract Background: Obesity is a multifactorial disease that is strongly associated to other metabolic disorders, such as insulin resistance and type 2 diabetes. Bariatric surgery is nowadays considered the most effective treatment of morbid obesity. The role of insulin resistance (IR) in weight loss after bariatric surgery is highly unknown. Aim: To evaluate the association between Insulin Resistance (IR) and percentage of excess weight loss (EWL%) one, two, three and four years after bariatric surgery in patients with morbid obesity. Methods: Retrospective longitudinal study in patients with morbid obesity followed in our centre between January 2010 and July 2018 were included. Patients were excluded if they had diabetes. We evaluated baseline Homeostatic Model Assessment of IR (HOMA-IR), Homeostatic Model Assessment of β-cell function (HOMA-beta), Quantitative Insulin Sensitivity Check Index (QUICKI) and Matsuda and DeFronzo index, and performed a linear regression concerning each year’s EWL%. Results: After applying the exclusion criteria, 1723 patients were included in this analysis. The logarithm of HOMA-beta was negatively associated with EWL% at second-, third- and fourth-years post-surgery (β=-1.04 [-1.82 to -0.26], p<0.01; β=-1.16 [-2.13 to -0.19], p=0.02; β=-1.29 [-2.64 to 0.06], p=0.061, respectively), adjusting for age, sex, body mass index and type of surgery. This was not observed in the first-year post-surgery nor for the other indexes. Glycaemia at baseline was also positively associated to EWL% at second- and third-years post-surgery. Conclusion: IR at baseline seems to be associated to long term weight loss, explicitly after the first year post bariatric surgery.

scholarly journals Beta Cell Function as a Baseline Predictor of Weight Loss After Bariatric Surgery

2021 ◽  
Vol 12 ◽  
Author(s):  
Marta Borges-Canha ◽  
João Sérgio Neves ◽  
Fernando Mendonça ◽  
Maria Manuel Silva ◽  
Cláudia Costa ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Weight Loss ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Model Assessment ◽  
Post Surgery ◽  
Homeostatic Model Assessment ◽  
Β Cell Function

BackgroundObesity is a multifactorial disease, which is strongly associated to other metabolic disorders. Bariatric surgery is the most effective treatment of morbid obesity. The role of beta cell function in weight loss after bariatric surgery is uncertain.AimTo evaluate the association between beta cell function and percentage of total body weight loss (TBWL%) 1, 2, 3, and 4 years after bariatric surgery in patients with morbid obesity.MethodsRetrospective longitudinal study in patients with morbid obesity followed in our center between January 2010 and July 2018. Patients were excluded if they had diabetes at baseline or missing data on the needed parameters. We evaluated baseline Homeostatic Model Assessment of IR, Homeostatic Model Assessment of β-cell function (HOMA-beta), Quantitative Insulin Sensitivity Check Index, and Matsuda and DeFronzo index, and TBWL% at years 1 to 4. Linear regression models were used to evaluate the association of indexes of insulin resistance with TBWL% (unadjusted and adjusted for age, sex, BMI, and type of surgery).ResultsThere were 1,561 patients included in this analysis. HOMA-beta was negatively associated with TBWL% at second, third, and fourth years post-surgery (β = −1.04 [−1.82 to −0.26], p<0.01; β = −1.16 [−2.13 to −0.19], p=0.02; β = −1.29 [−2.64 to 0.06], p=0.061, respectively). This was not observed in the first year post-surgery nor for the other indexes. Glycemia at baseline was positively associated to EWL% at second and third years post-surgery.Conclusionβ-cell function at baseline seems to be associated to long-term weight loss, explicitly after the first year post bariatric surgery. This might be a helpful predictor of weight loss in clinical practice.

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