scholarly journals Fibroblast Growth Factor 21 (FGF21) and Glucagon-Like Peptide 1 Contribute to Diabetes Resistance in Glucagon Receptor-Deficient Mice

Diabetes ◽  
2013 ◽  
Vol 63 (1) ◽  
pp. 101-110 ◽  
Author(s):  
B. A. Omar ◽  
B. Andersen ◽  
J. Hald ◽  
K. Raun ◽  
E. Nishimura ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Glucagon Receptor ◽  
Glucagon Like Peptide ◽  
Glucagon Like Peptide 1 ◽  
Deficient Mice

scholarly journals Fibroblast growth factor 21 is required for beneficial effects of exercise during chronic high-fat feeding

2016 ◽  
Vol 121 (3) ◽  
pp. 687-698 ◽  
Author(s):  
Christine Loyd ◽  
I. Jack Magrisso ◽  
Michael Haas ◽  
Sowmya Balusu ◽  
Radha Krishna ◽  
...  
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Metabolic Effects ◽  
Fibroblast Growth Factor 21 ◽  
Protein Kinase Activity ◽  
Fibroblast Growth ◽  
High Fat ◽  
Glucagon Receptor ◽  
The Metabolic Syndrome ◽  
Physiological Tests

Exercise is an effective therapy against the metabolic syndrome. However, the molecular pathways underlying the advantageous effects of exercise are elusive. Glucagon receptor signaling is essential for exercise benefits, and recent evidence indicates that a downstream effector of glucagon, fibroblast growth factor 21 (FGF21), is implicated in this response. Therefore, we tested the hypothesis that FGF21 action is necessary in mediating metabolic effects of exercise. We utilized acute exhaustive treadmill exercise in Wistar rats to identify a putative, concomitant increase in plasma glucagon and FGF21 with the increase in glucose and lactate following exercise. To test the necessity of FGF21 action in the exercise response, we exposed FGF21 congenitally deficient mice ( Fgf21 −/−) and their wild-type (Wt) littermates to chronic high-fat (HF) feeding and inoperable (sedentary) or operable (exercise) voluntary running wheels. Physiological tests were performed to assess the role of FGF21 in the beneficial effect of exercise on glucose metabolism. Wt and Fgf21 −/− littermates exhibited similar running behavior, and exercise was effective in suppressing weight and fat mass gain and dyslipidemia independently of genotype. However, exercise failed to positively affect hepatic triglyceride content and glucose tolerance in HF diet-fed Fgf21 −/− mice. Furthermore, Fgf21 −/− mice exhibited an impaired adaptation to exercise training, including reduced AMP-activated protein kinase activity in skeletal muscle. This study demonstrates that FGF21 action is necessary to achieve the full metabolic benefits of exercise during chronic HF feeding.

scholarly journals Roux-en-Y gastric bypass surgery is effective in fibroblast growth factor-21 deficient mice

2016 ◽  
Vol 5 (10) ◽  
pp. 1006-1014 ◽  
Author(s):  
Christopher D. Morrison ◽  
Zheng Hao ◽  
Michael B. Mumphrey ◽  
R. Leigh Townsend ◽  
Heike Münzberg ◽  
...  
Keyword(s):  
Gastric Bypass ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Bypass Surgery ◽  
Gastric Bypass Surgery ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Deficient Mice

scholarly journals Fibroblast Growth Factor 21-Deficient Mice Demonstrate Impaired Adaptation to Ketosis

Endocrinology ◽  
2009 ◽  
Vol 150 (11) ◽  
pp. 4931-4940 ◽  
Author(s):  
Michael K. Badman ◽  
Anja Koester ◽  
Jeffrey S. Flier ◽  
Alexei Kharitonenkov ◽  
Eleftheria Maratos-Flier
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Deficient Mice

scholarly journals Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21

Diabetes ◽  
2018 ◽  
Vol 67 (9) ◽  
pp. 1773-1782 ◽  
Author(s):  
Teayoun Kim ◽  
Shelly Nason ◽  
Cassie Holleman ◽  
Mark Pepin ◽  
Landon Wilson ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Farnesoid X Receptor ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Receptor Signaling ◽  
Glucagon Receptor
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