scholarly journals Autologous Pancreatic Islet Transplantation in Human Bone Marrow

Diabetes ◽  
2013 ◽  
Vol 62 (10) ◽  
pp. 3523-3531 ◽  
Author(s):  
P. Maffi ◽  
G. Balzano ◽  
M. Ponzoni ◽  
R. Nano ◽  
V. Sordi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Pancreatic Islet Transplantation

scholarly journals Autologous Pancreatic Islet Transplantation in Human Bone Marrow. Diabetes 2013;62:3523-3531

Diabetes ◽  
2013 ◽  
Vol 63 (1) ◽  
pp. 377-377
Author(s):  
P. Maffi ◽  
G. Balzano ◽  
M. Ponzoni ◽  
R. Nano ◽  
V. Sordi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Pancreatic Islet Transplantation

Bone marrow as an alternative site for islet transplantation

Blood ◽  
2009 ◽  
Vol 114 (20) ◽  
pp. 4566-4574 ◽  
Author(s):  
Elisa Cantarelli ◽  
Raffaella Melzi ◽  
Alessia Mercalli ◽  
Valeria Sordi ◽  
Giuliana Ferrari ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Bone Structure ◽  
Fold Increase ◽  
Lymphocytic Choriomeningitis ◽  
Pancreatic Islet Transplantation ◽  
Safe Alternative ◽  
Cellular Transplantation ◽  
Alternative Site

Abstract The liver is the current site for pancreatic islet transplantation, but has many drawbacks due to immunologic and nonimmunologic factors. We asked whether pancreatic islets could be engrafted in the bone marrow (BM), an easily accessible and widely distributed transplant site that may lack the limitations seen in the liver. Syngeneic islets engrafted efficiently in the BM of C57BL/6 mice rendered diabetic by streptozocin treatment. For more than 1 year after transplantation, these animals showed parameters of glucose metabolism that were similar to those of nondiabetic mice. Islets in BM had a higher probability to reach euglycemia than islets in liver (2.4-fold increase, P = .02), showed a compact morphology with a conserved ratio between α and β cells, and affected bone structure only very marginally. Islets in BM did not compromise hematopoietic activity, even when it was strongly induced in response to a BM aplasia-inducing infection with lymphocytic choriomeningitis virus. In conclusion, BM is an attractive and safe alternative site for pancreatic islet transplantation. The results of our study open a research line with potentially significant clinical impact, not only for the treatment of diabetes, but also for other diseases amenable to treatment with cellular transplantation.

Bone marrow as a site for pancreatic islet transplantation

Blood ◽  
2010 ◽  
Vol 115 (17) ◽  
pp. 3643-3644 ◽  
Author(s):  
Anastasio Salazar-Bañuelos ◽  
Luis Benitez-Bribiesca ◽  
David L. Sigalet ◽  
Greg Korbutt ◽  
James R. Wright
Keyword(s):  
Bone Marrow ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation ◽  
A Site

Pancreatic islet transplantation into the bone marrow of the rat

2008 ◽  
Vol 195 (5) ◽  
pp. 674-678 ◽  
Author(s):  
Anastasio Salazar-Bañuelos ◽  
James R. Wright ◽  
David Sigalet ◽  
Luis Benítez-Bribiesca
Keyword(s):  
Bone Marrow ◽  
Islet Transplantation ◽  
Pancreatic Islet ◽  
Pancreatic Islet Transplantation

The human bone marrow (BM) niche in acute leukaemia

2017 ◽  
Author(s):  
D Pal ◽  
H Blair ◽  
S Boyd ◽  
P Bakelis ◽  
A Elder ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Acute Leukaemia ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Bm Niche
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