Protection of Islet Grafts Through Transforming Growth Factor-β–Induced Tolerogenic Dendritic Cells

David C. Thomas; F. Susan Wong; Paola Zaccone; E. Allison Green; Maja Wållberg

doi:10.2337/db12-1740

Protection of Islet Grafts Through Transforming Growth Factor-β–Induced Tolerogenic Dendritic Cells

Diabetes ◽

10.2337/db12-1740 ◽

2013 ◽

Vol 62 (9) ◽

pp. 3132-3142 ◽

Cited By ~ 26

Author(s):

David C. Thomas ◽

F. Susan Wong ◽

Paola Zaccone ◽

E. Allison Green ◽

Maja Wållberg

Keyword(s):

Dendritic Cells ◽

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Tolerogenic Dendritic Cells

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Blocking of p38 and transforming growth factor β receptor pathways impairs the ability of tolerogenic dendritic cells to suppress murine arthritis

Arthritis & Rheumatism ◽

10.1002/art.37702 ◽

2012 ◽

Vol 65 (1) ◽

pp. 120-129 ◽

Cited By ~ 16

Author(s):

David Gárate ◽

Nicole Rojas-Colonelli ◽

Corina Peña ◽

Lorena Salazar ◽

Paula Abello ◽

...

Keyword(s):

Dendritic Cells ◽

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Tolerogenic Dendritic Cells ◽

Β Receptor

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The siRNA cocktail targeting interleukin 10 receptor and transforming growth factor‐β receptor on dendritic cells potentiates tumour antigen‐specific CD8 + T cell immunity

Clinical & Experimental Immunology ◽

10.1111/cei.12620 ◽

2015 ◽

Vol 181 (1) ◽

pp. 164-178 ◽

Cited By ~ 31

Author(s):

Y.‐H. Ahn ◽

S.‐O. Hong ◽

J. H. Kim ◽

K. H. Noh ◽

K.‐H. Song ◽

...

Keyword(s):

Dendritic Cells ◽

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Cd8 T Cell ◽

Interleukin 10 ◽

T Cell Immunity ◽

Cell Immunity ◽

Β Receptor ◽

Sirna Cocktail

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Increased serum transforming growth factor-β 1 in human colorectal cancer correlates with reduced circulating dendritic cells and increased colonic Langerhans cell infiltration

Clinical & Experimental Immunology ◽

10.1046/j.1365-2249.2003.02295.x ◽

2003 ◽

Vol 134 (2) ◽

pp. 270-278 ◽

Cited By ~ 37

Author(s):

A. HUANG ◽

J. W. GILMOUR ◽

N. IMAMI ◽

P. AMJADI ◽

D. C. HENDERSON ◽

...

Keyword(s):

Colorectal Cancer ◽

Dendritic Cells ◽

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Langerhans Cell ◽

Cell Infiltration ◽

Human Colorectal Cancer

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212. TOLEROGENIC DENDRITIC CELLS REGULATE T CELLS VIA TRANSFORMING GROWTH FACTOR BETA

Rheumatology ◽

10.1093/rheumatology/kex062.213 ◽

2017 ◽

Vol 56 (suppl_2) ◽

Author(s):

Oi Yean Wong ◽

Catharien Hilkens

Keyword(s):

T Cells ◽

Dendritic Cells ◽

Growth Factor ◽

Transforming Growth Factor Beta ◽

Transforming Growth Factor ◽

Tolerogenic Dendritic Cells ◽

Growth Factor Beta

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Transforming growth factor β signaling inhibitor, SB-431542, induces maturation of dendritic cells and enhances anti-tumor activity

Oncology Reports ◽

10.3892/or_00001028 ◽

2010 ◽

Vol 24 (6) ◽

Cited By ~ 27

Author(s):

Tanaka

Keyword(s):

Dendritic Cells ◽

Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Anti Tumor Activity

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Intestinal Dendritic Cells Specialize to Activate Transforming Growth Factor-β and Induce Foxp3+ Regulatory T Cells via Integrin αvβ8

Gastroenterology ◽

10.1053/j.gastro.2011.06.057 ◽

2011 ◽

Vol 141 (5) ◽

pp. 1802-1812 ◽

Cited By ~ 102

Author(s):

John J. Worthington ◽

Beata I. Czajkowska ◽

Andrew C. Melton ◽

Mark A. Travis

Keyword(s):

T Cells ◽

Dendritic Cells ◽

Growth Factor ◽

Regulatory T Cells ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β

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Tolerogenic dendritic cells generated with dexamethasone and vitamin D3 regulate rheumatoid arthritis CD4+T cells partly via transforming growth factor-β1

Clinical & Experimental Immunology ◽

10.1111/cei.12870 ◽

2016 ◽

Vol 187 (1) ◽

pp. 113-123 ◽

Cited By ~ 23

Author(s):

A. E. Anderson ◽

D. J. Swan ◽

O. Y. Wong ◽

M. Buck ◽

O. Eltherington ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

T Cells ◽

Dendritic Cells ◽

Growth Factor ◽

Vitamin D3 ◽

Cd4 T Cells ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β1 ◽

Tolerogenic Dendritic Cells

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Breast cancer-derived transforming growth factor-β and tumor necrosis factor-α compromise interferon-α production by tumor-associated plasmacytoid dendritic cells

International Journal of Cancer ◽

10.1002/ijc.28072 ◽

2013 ◽

Vol 133 (3) ◽

pp. 771-778 ◽

Cited By ~ 43

Author(s):

Vanja Sisirak ◽

Nelly Vey ◽

Nadège Goutagny ◽

Sarah Renaudineau ◽

Marine Malfroy ◽

...

Keyword(s):

Breast Cancer ◽

Dendritic Cells ◽

Growth Factor ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Interferon Α ◽

Factor Α ◽

Necrosis Factor

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Interleukin-1α, Epidermal Growth Factor, and Transforming Growth Factor-β Exhibit Differential Kinetics on Endothelin-1 Synthesis in Amnion Cells

Journal of the Society for Gynecologic Investigation ◽

10.1016/s1071-5576(97)00102-0 ◽

1998 ◽

Vol 5 (1) ◽

pp. 25-30 ◽

Cited By ~ 2

Author(s):

D McKenna

Keyword(s):

Growth Factor ◽

Epidermal Growth Factor ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Endothelin 1 ◽

Epidermal Growth ◽

Interleukin 1Α

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Perianale Fisteln bei CED: vom Mausmodell zur Klinik

Therapeutische Umschau ◽

10.1024/0040-5930/a001000 ◽

2018 ◽

Vol 75 (5) ◽

pp. 287-294

Author(s):

Michael Scharl

Keyword(s):

Growth Factor ◽

Morbus Crohn ◽

Transforming Growth Factor ◽

Transforming Growth Factor Β ◽

Interleukin 13

Zusammenfassung. Fisteln stellen nach wie vor eine der wichtigsten Komplikationen bei Patienten mit Morbus Crohn dar. Bei mindestens einem Drittel aller Morbus Crohn Patienten treten im Laufe der Erkrankung Fisteln auf. Eine dauerhafte Heilung der Fistel wird jedoch, auch unter Ausschöpfung sämtlicher medikamentöser und chirurgischer Therapieoptionen, nur in rund einem Drittel dieser Patienten erreicht. Der genaue molekulare Mechanismus der Fistelentstehung ist bis heute nicht ganz klar. Aus histopathologischer Sichtweise stellen Fisteln eine röhrenartige Struktur dar, welche von flachen epithelartigen Zellen ausgekleidet ist. Als ursächlicher Entstehungsmechanismus wird dabei die sogenannte epitheliale-zu-mesenchymale Transition (EMT) angesehen und es kann eine starke Expression der Entzündungsmediatoren Tumor Nekrose Faktor, Interleukin-13 und Transforming Growth Factor β in den Fistelarealen nachgewiesen werden. Zusätzlich zu den bereits etablierten, medikamentösen Therapieoptionen, also Antibiotika, Immunmodulatoren und anti-TNF Antikörper, stellt insbesondere der Einsatz der mesenchymalen Stammzelltherapie einen erfolgversprechenden Therapieansatz für die Zukunft dar.

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