scholarly journals Fyn Deficiency Promotes a Preferential Increase in Subcutaneous Adipose Tissue Mass and Decreased Visceral Adipose Tissue Inflammation

Diabetes ◽  
2013 ◽  
Vol 62 (5) ◽  
pp. 1537-1546 ◽  
Author(s):  
T.-W. A. Lee ◽  
H. Kwon ◽  
H. Zong ◽  
E. Yamada ◽  
M. Vatish ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Tissue Mass ◽  
Tissue Inflammation ◽  
Adipose Tissue Mass ◽  
Visceral Adipose ◽  
Subcutaneous Adipose

scholarly journals Exercise-Induced Changes in Visceral Adipose Tissue Mass Are Regulated by IL-6 Signaling: A Randomized Controlled Trial

2019 ◽  
Vol 29 (4) ◽  
pp. 844-855.e3 ◽  
Author(s):  
Anne-Sophie Wedell-Neergaard ◽  
Louise Lang Lehrskov ◽  
Regitse Højgaard Christensen ◽  
Grit Elster Legaard ◽  
Emma Dorph ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Controlled Trial ◽  
Tissue Mass ◽  
Randomized Controlled ◽  
Adipose Tissue Mass ◽  
Exercise Induced ◽  
Induced Changes ◽  
Visceral Adipose

Regional Variation in Plasminogen Activator Inhibitor-1 Expression in Adipose Tissue from Obese Individuals

2000 ◽  
Vol 83 (04) ◽  
pp. 545-548 ◽  
Author(s):  
Vanessa Van Harmelen ◽  
Johan Hoffstedt ◽  
Per Lundquist ◽  
Hubert Vidal ◽  
Veronika Stemme ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Subcutaneous Adipose Tissue ◽  
Plasminogen Activator Inhibitor ◽  
Plasminogen Activator Inhibitor 1 ◽  
Visceral Adipose ◽  
Subcutaneous Adipose ◽  
Activator Inhibitor ◽  
Pai 1

SummaryHigh plasma plasminogen activator inhibitor-1 (PAI-1) activity is a frequent finding in obesity and adipose tissue has recently been suggested to be a source of circulating PAI-1 in humans. In the present study, differences in adipose tissue gene expression and protein secretion rate of PAI-1 between subcutaneous and visceral adipose tissue was analysed in specimens obtained from 22 obese individuals. The secretion rate of PAI-1 was two-fold higher in subcutaneous adipose tissue than in visceral adipose tissue (292 ± 50 vs 138 ± 24 ng PAI-1/107 cells, P <0.05). In accordance with the secretion data, subcutaneous adipose tissue contained about three-fold higher levels of PAI-1 mRNA than visceral adipose tissue (2.43 ± 0.37 vs 0.81 ± 0.12 attomole PAI-1 mRNA/µg total RNA, P <0.001). PAI-1 secretion from subcutaneous but not from visceral adipose tissue correlated significantly with cell size (r = 0.43, P <0.05). In summary, subcutaneous adipose tissue secreted greater amounts of PAI-1 and had a higher PAI-1 gene expression than visceral adipose tissue from the same obese individuals. Bearing in mind that subcutaneous adipose tissue is the largest fat depot these finding may be important for the coagulation abnormalities associated with obesity.

scholarly journals miR-30a Remodels Subcutaneous Adipose Tissue Inflammation to Improve Insulin Sensitivity in Obesity

Diabetes ◽  
2018 ◽  
Vol 67 (12) ◽  
pp. 2541-2553 ◽  
Author(s):  
Eun-Hee Koh ◽  
Natasha Chernis ◽  
Pradip K. Saha ◽  
Liuling Xiao ◽  
David A. Bader ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Insulin Sensitivity ◽  
Subcutaneous Adipose Tissue ◽  
Adipose Tissue Inflammation ◽  
Improve Insulin Sensitivity ◽  
Tissue Inflammation ◽  
Subcutaneous Adipose
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