scholarly journals Loss of Pulsatile Insulin Secretion: A Factor in the Pathogenesis of Type 2 Diabetes?

Diabetes ◽  
2012 ◽  
Vol 61 (9) ◽  
pp. 2228-2229 ◽  
Author(s):  
J. Wahren ◽  
A. Kallas
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Pulsatile Insulin Secretion

scholarly journals Assessment of pulsatile insulin secretion derived from peripheral plasma C-peptide concentrations by nonparametric stochastic deconvolution

2019 ◽  
Vol 316 (5) ◽  
pp. E687-E694 ◽  
Author(s):  
Marcello C. Laurenti ◽  
Adrian Vella ◽  
Ron T. Varghese ◽  
James C. Andrews ◽  
Anu Sharma ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Hepatic Vein ◽  
A Priori ◽  
Simulated Data ◽  
Systemic Circulation ◽  
C Peptide ◽  
Pulsatile Insulin Secretion ◽  
Do So

The characteristics of pulsatile insulin secretion are important determinants of type 2 diabetes pathophysiology, but they are understudied due to the difficulties in measuring pulsatile insulin secretion noninvasively. Deconvolution of either peripheral C-peptide or insulin concentrations offers an appealing alternative to hepatic vein catheterization. However, to do so, there are a series of methodological challenges to overcome. C-peptide has a relatively long half-life and accumulates in the circulation. On the other hand, peripheral insulin concentrations reflect relatively fast clearance and hepatic extraction as it leaves the portal circulation to enter the systemic circulation. We propose a method based on nonparametric stochastic deconvolution of C-peptide concentrations, using individually determined C-peptide kinetics, to overcome these limitations. The use of C-peptide (instead of insulin) concentrations allows estimation of portal (and not post-hepatic) insulin pulses, whereas nonparametric stochastic deconvolution allows evaluation of pulsatile signals without any a priori assumptions of pulse shape and occurrence. The only assumption required is the degree of smoothness of the (unknown) secretion rate. We tested this method first on simulated data and then on 29 nondiabetic subjects studied during euglycemia and hyperglycemia and compared our estimates with the profiles obtained from hepatic vein insulin concentrations. This method produced satisfactory results both in the ability to fit the data and in providing reliable estimates of pulsatile secretion, in agreement with hepatic vein measurements. In conclusion, the proposed method enables reliable and noninvasive measurement of pulsatile insulin secretion. Future studies will be needed to validate this method in people with type 2 diabetes.

Metabolic and electrical oscillations: partners in controlling pulsatile insulin secretion

2007 ◽  
Vol 293 (4) ◽  
pp. E890-E900 ◽  
Author(s):  
Richard Bertram ◽  
Arthur Sherman ◽  
Leslie S. Satin
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Cell Model ◽  
Physiological Role ◽  
Pancreatic Islets Of Langerhans ◽  
The Subject ◽  
Pulsatile Insulin Secretion ◽  
Direct Confirmation ◽  
Made In

Impairment of insulin secretion from the β-cells of the pancreatic islets of Langerhans is central to the development of type 2 diabetes mellitus and has therefore been the subject of much investigation. Great advances have been made in this area, but the mechanisms underlying the pulsatility of insulin secretion remain controversial. The period of these pulses is 4–6 min and reflects oscillations in islet membrane potential and intracellular free Ca2+. Pulsatile blood insulin levels appear to play an important physiological role in insulin action and are lost in patients with type 2 diabetes and their near relatives. We present evidence for a recently developed β-cell model, the “dual oscillator model,” in which oscillations in activity are due to both electrical and metabolic mechanisms. This model is capable of explaining much of the available data on islet activity and offers possible resolutions of a number of longstanding issues. The model, however, still lacks direct confirmation and raises new issues. In this article, we highlight both the successes of the model and the challenges that it poses for the field.

scholarly journals Failure of physiological plasma glucose excursions to entrain high-frequency pulsatile insulin secretion in type 2 diabetes

Diabetes ◽  
2000 ◽  
Vol 49 (8) ◽  
pp. 1334-1340 ◽  
Author(s):  
M. Hollingdal ◽  
C. B. Juhl ◽  
S. M. Pincus ◽  
J. Sturis ◽  
J. D. Veldhuis ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Plasma Glucose ◽  
High Frequency ◽  
Pulsatile Insulin Secretion

scholarly journals Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes

2015 ◽  
Vol 42 ◽  
pp. 61-77 ◽  
Author(s):  
Leslie S. Satin ◽  
Peter C. Butler ◽  
Joon Ha ◽  
Arthur S. Sherman
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Glucose Tolerance ◽  
Impaired Glucose Tolerance ◽  
Pulsatile Insulin Secretion

scholarly journals Acute and Short-Term Administration of a Sulfonylurea (Gliclazide) Increases Pulsatile Insulin Secretion in Type 2 Diabetes

Diabetes ◽  
2001 ◽  
Vol 50 (8) ◽  
pp. 1778-1784 ◽  
Author(s):  
C. B. Juhl ◽  
N. Porksen ◽  
S. M. Pincus ◽  
A. P. Hansen ◽  
J. D. Veldhuis ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Short Term ◽  
Term Administration ◽  
Pulsatile Insulin Secretion

1516-P: A Comparison of the Contributions of Impaired Insulin Secretion and Insulin Resistance to the Development of Type 2 Diabetes in a Japanese Community: The Hisayama Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 1516-P
Author(s):  
MASAHITO YOSHINARI ◽  
YOICHIRO HIRAKAWA ◽  
JUN HATA ◽  
MAYU HIGASHIOKA ◽  
TAKANORI HONDA ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Impaired Insulin Secretion ◽  
Impaired Insulin

755-P: A Plant-Based Meal Stimulates Incretin and Insulin Secretion More than an Energy- and Macronutrient-Matched Standard Meal in Type 2 Diabetes: A Randomized Crossover Study

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 755-P
Author(s):  
HANA KAHLEOVA ◽  
ANDREA TURA ◽  
MARTA KLEMENTOVA ◽  
LENKA BELINOVA ◽  
MARTIN HALUZIK ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Secretion ◽  
Crossover Study ◽  
Standard Meal ◽  
Randomized Crossover Study
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