scholarly journals Evidence That Hyperglycemia After Recovery From Hypoglycemia Worsens Endothelial Function and Increases Oxidative Stress and Inflammation in Healthy Control Subjects and Subjects With Type 1 Diabetes

Diabetes ◽  
2012 ◽  
Vol 61 (11) ◽  
pp. 2993-2997 ◽  
Author(s):  
A. Ceriello ◽  
A. Novials ◽  
E. Ortega ◽  
L. La Sala ◽  
G. Pujadas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 1 Diabetes ◽  
Endothelial Function ◽  
Control Subjects ◽  
Healthy Control

scholarly journals Parent Report of Mealtime Behavior and Parenting Stress in Young Children With Type 1 Diabetes and in Healthy Control Subjects

Diabetes Care ◽  
2002 ◽  
Vol 25 (2) ◽  
pp. 313-318 ◽  
Author(s):  
S. W. Powers ◽  
K. C. Byars ◽  
M. J. Mitchell ◽  
S. R. Patton ◽  
D. A. Standiford ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Young Children ◽  
Parenting Stress ◽  
Parent Report ◽  
Control Subjects ◽  
Mealtime Behavior ◽  
Healthy Control

scholarly journals Type 1 Diabetes Modifies Brain Activation in Young Patients While Performing Visuospatial Working Memory Tasks

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Geisa B. Gallardo-Moreno ◽  
Andrés A. González-Garrido ◽  
Esteban Gudayol-Ferré ◽  
Joan Guàrdia-Olmos
Keyword(s):  
Working Memory ◽  
Type 1 Diabetes ◽  
Young Patients ◽  
Brain Activation ◽  
Behavioral Performance ◽  
Visuospatial Working Memory ◽  
Control Subjects ◽  
Compensation Mechanisms ◽  
Healthy Control

In recent years, increasing attention has been paid to the effects of Type 1 Diabetes (T1D) on cognitive functions. T1D onset usually occurs during childhood, so it is possible that the brain could be affected during neurodevelopment. We selected young patients of normal intelligence with T1D onset during neurodevelopment, no complications from diabetes, and adequate glycemic control. The purpose of this study was to compare the neural BOLD activation pattern in a group of patients with T1Dversushealthy control subjects while performing a visuospatial working memory task. Sixteen patients and 16 matched healthy control subjects participated. There was no significant statistical difference in behavioral performance between the groups, but, in accordance with our hypothesis, results showed distinct brain activation patterns. Control subjects presented the expected activations related to the task, whereas the patients had greater activation in the prefrontal inferior cortex, basal ganglia, posterior cerebellum, and substantia nigra. These different patterns could be due to compensation mechanisms that allow them to maintain a behavioral performance similar to that of control subjects.

scholarly journals Children and adolescents with type 1 diabetes eat a more atherosclerosis-prone diet than healthy control subjects

Diabetologia ◽  
2006 ◽  
Vol 50 (2) ◽  
pp. 307-316 ◽  
Author(s):  
N. C. Øverby ◽  
V. Flaaten ◽  
M. B. Veierød ◽  
I. Bergstad ◽  
H. D. Margeirsdottir ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Children And Adolescents ◽  
Control Subjects ◽  
Healthy Control

scholarly journals Simultaneous Control of Hyperglycemia and Oxidative Stress Normalizes Endothelial Function in Type 1 Diabetes

Diabetes Care ◽  
2007 ◽  
Vol 30 (3) ◽  
pp. 649-654 ◽  
Author(s):  
A. Ceriello ◽  
S. Kumar ◽  
L. Piconi ◽  
K. Esposito ◽  
D. Giugliano
Keyword(s):  
Oxidative Stress ◽  
Type 1 Diabetes ◽  
Endothelial Function ◽  
Simultaneous Control ◽  
And Oxidative Stress

scholarly journals Detection of Mycobacterium avium subsp. paratuberculosis in Iranian patients with type 1 diabetes mellitus by PCR and ELISA

2016 ◽  
Vol 10 (08) ◽  
pp. 857-862 ◽  
Author(s):  
Sonia Hesam Shariati ◽  
Anoosha Alaei ◽  
Rouhollah Keshavarz ◽  
Nader Mosavari ◽  
Ali Rabbani ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Mycobacterium Avium ◽  
Mycobacterium Avium Subsp ◽  
Blood Samples ◽  
Control Subjects ◽  
Healthy Control ◽  
Mycobacterium Avium Subsp Paratuberculosis

Introduction: Mycobacterium avium subsp. paratuberculosis (MAP) is the causative agent of paratuberculosis or Johne’s disease in ruminants. Its role in triggering autoimmunity, including type 1 diabetes mellitus (T1DM), has been reported in recent years. Due to the high contamination rate of MAP in Iran’s livestock and the increasing outbreak of T1DM, we investigated this association in a small group of patients with T1DM in Iran. Methodology: Blood samples of 29 T1DM patients and 29 healthy control subjects were tested through enzyme-linked immunosorbent assay (ELISA) to detect antibodies against MAP3865c and ZnT8 homologous epitopes and the presence of MAP DNA. Blood samples were also cultured in mycobacterial growth indicator tubes and Herrold's egg yolk medium containing mycobactin J. Results: The results of ELISA showed a significant difference between T1DM patients and healthy group. IS900 was also detected in 51.72% of T1DM patients but in none of the control group. None of the samples grew in culture media. Conclusions: Due to the presence of MAP DNA and antibodies against MAP peptides in a significant number of T1DM patients compared with healthy control subjects, we may consider MAP as a possible trigger of T1DM in Iran. This indicates that exposure to MAP occurred in the positive subjects. Identifying the sources of contamination and routes of MAP transmission to humans seems necessary to prevent and reduce the burden of MAP infection in Iran.

scholarly journals OR08-06 Increased Carotid Intima Media Thickness in Pediatric Type 1 Diabetes Is Associated with Disease Duration

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Michal Cohen ◽  
Meirav Oren ◽  
Raya Gendelman ◽  
Hiba Yaseen ◽  
Ram Weiss ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Type 1 Diabetes ◽  
Endothelial Function ◽  
Disease Duration ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Recent Onset ◽  
Control Subjects

Abstract Background & Objective Patients with type-1-diabetes (T1D) are at risk of long-term micro and macrovascular complications causing significant morbidity and mortality. Overt complications are not common in childhood; however, subclinical impairments in endothelial function, may be found. Better understanding of the timeline for the appearance of diabetic complications and identifying individuals at increased risk is key for developing prevention strategies. We aimed to study endothelial function and it’s determinants in adolescents with T1D at different time points from diagnosis. Methods Forty adolescents 11-20 years of age with T1D followed at our pediatric diabetes clinic and 18 healthy control subjects were included. Two groups of patients were recruited based on time from T1D diagnosis; 20 individuals were diagnosed 2-4 months prior to the study visit and 20 at least 7 years prior to the visit. Investigations included: i) medical and demographic data ii) anthropometrics iii) fasting blood samples iv) EndoPAT testing of endothelial function and heart rate variability (Itamar Medical Ltd., Israel) v) Carotid intima media thickness (CIMT). Results Mean age differed slightly between groups being 14.1±2.0years in individuals with recent-onset T1D, 16.2±2.5 in those with prolonged T1D, and 14.8±2.3 in the control group (p=0.02). There were no significant differences in pubertal stage or in BMI z-score between groups. Thirty-three (57%) females participated. No patient suffered from diabetic complications. Mean CIMT was significantly higher in individuals with prolonged T1D (0.49±0.07mm) compared to control subjects (0.43±0.05mm; p=0.013) and did not differ significantly between patients with recent-onset T1D (0.45±0.07mm) and controls. This difference remained significant when age and sex were included in the model. EndoPAT measures of endothelial function and heart rate variability did not differ significantly between groups. Mean HbA1c at the time of the visit differed between groups (6.7%±0.7, 9.6%±1.8, 5.4%±0.3, p<0.001). However, the average of HbA1c reflecting the 6-7 months prior to the visit did not differ significantly between subjects with recent onset T1D (9.8%±1.3) and those with prolonged T1D (9.5%±1.7). LDL was higher in subjects with prolonged T1D (114±28mg/dl) compared to either controls (93±26mg/dl) or recent onset T1D (88±19mg/dl),p=0.002. Diastolic blood pressure was higher in subjects with prolonged T1D (70±6mmHg) than in controls (61±6, p=0.007). Conclusions Our results demonstrate disease duration to be an important factor in the development of subclinical arterial damage in the pediatric age group. Early in the course of T1D, CIMT results were similar in patients and control subjects, suggesting an important window for prevention. Larger studies could shed light on the precise timeline of endothelial impairment.

scholarly journals Gut Microbiota Differs in Composition and Functionality Between Children With Type 1 Diabetes and MODY2 and Healthy Control Subjects: A Case-Control Study

Diabetes Care ◽  
2018 ◽  
Vol 41 (11) ◽  
pp. 2385-2395 ◽  
Author(s):  
Isabel Leiva-Gea ◽  
Lidia Sánchez-Alcoholado ◽  
Beatriz Martín-Tejedor ◽  
Daniel Castellano-Castillo ◽  
Isabel Moreno-Indias ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gut Microbiota ◽  
Case Control Study ◽  
Case Control ◽  
Control Subjects ◽  
Healthy Control ◽  
Control Study
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