scholarly journals Comment on: Sorensen et al. Maternal Serum Levels of 25-Hydroxy-Vitamin D During Pregnancy and Risk of Type 1 Diabetes in the Offspring. Diabetes 2012;61:175-178

Diabetes ◽  
2012 ◽  
Vol 61 (7) ◽  
pp. e8-e8 ◽  
Author(s):  
S. Niinisto ◽  
L. Uusitalo ◽  
M. E. Miettinen ◽  
S. M. Virtanen
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Serum Levels ◽  
Maternal Serum ◽  
25 Hydroxy Vitamin D

scholarly journals Maternal Serum Levels of 25-Hydroxy-Vitamin D During Pregnancy and Risk of Type 1 Diabetes in the Offspring

Diabetes ◽  
2011 ◽  
Vol 61 (1) ◽  
pp. 175-178 ◽  
Author(s):  
I. M. Sorensen ◽  
G. Joner ◽  
P. A. Jenum ◽  
A. Eskild ◽  
P. A. Torjesen ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Serum Levels ◽  
Maternal Serum ◽  
25 Hydroxy Vitamin D

scholarly journals A dose–response meta-analysis between serum concentration of 25-hydroxy vitamin D and risk of type 1 diabetes mellitus

2020 ◽  
Author(s):  
Yilin Hou ◽  
An Song ◽  
Yuxin Jin ◽  
Qiuyang Xia ◽  
Guangyao Song ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Type 1 Diabetes Mellitus ◽  
Dose Response ◽  
Meta Analysis ◽  
Cochrane Library ◽  
25 Hydroxy Vitamin D ◽  
Meta Regression

AbstractIt remains debatable whether vitamin D plays any role as a risk factor for type 1 diabetes mellitus (T1DM). We have summarized the effect of circulating 25-hydroxy vitamin D [25(OH)D] concentration on the risk of developing T1DM via a dose–response meta-analysis. We undertook a database search on PubMed, Embase, and Cochrane Library from inception to January 2020. A meta-analysis based on random-effects model was applied. Subgroup analysis and meta-regression were performed to inspect the source of heterogeneity. Dose–response data were examined using the generalized least squares trend estimation method. This study was registered with the PROSPERO (ID: CRD42020166174). In total, 16 studies including 10,605 participants (3913 case patients) were included. The pooled odds ratios (OR) and 95% confidence intervals (95% CI) for the highest versus the lowest 25(OH)D concentration was 0.39 (0.27, 0.57), with a high heterogeneity (I2 = 76.7%, P < 0.001). Meta-regression analysis identified latitude (P = 0.02), adjustment for gender (P = 0.001), and 25(OH)D stratification (P < 0.001) as sources of heterogeneity. Furthermore, the nonlinear dose–response analysis determined the OR (95% CI) of T1DM to be 0.91 (0.90, 0.93) per 10 nmol/L increase in the 25(OH)D concentration. A ‘U’-shaped association was found between serum 25(OH)D concentration and risk of T1DM. The present study highlights the significant inverse association between the circulating 25(OH)D concentration and the risk of T1DM.

Association of Serum Levels of Vitamin D and Interleukin 6 in Type 1 Diabetes in an Egyptian Population

2020 ◽  
Vol 11 (2) ◽  
pp. 1180
Author(s):  
Ashraf M. Osman ◽  
Hanan M. Kamel ◽  
Lamia H. Ali ◽  
Hend M. Moness ◽  
Dalia A. Meshref
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Interleukin 6 ◽  
Serum Levels ◽  
Egyptian Population

scholarly journals Association of Average Telomere Length with Body-Mass Index and Vitamin D Status in Juvenile Population with Type 1 Diabetes / Povezava Povprečnih Dolžin Telomerov Z Indeksom Telesne Teže in Vitaminom D Pri Mladostnikih S Sladkorno Boleznijo Tipa 1

2015 ◽  
Vol 54 (2) ◽  
pp. 74-78 ◽  
Author(s):  
Tine Tesovnik ◽  
Jernej Kovac ◽  
Tinka Hovnik ◽  
Primoz Kotnik ◽  
Tadej Battelino ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Vitamin D ◽  
Type 1 Diabetes ◽  
Serum Vitamin ◽  
Serum Levels ◽  
Glycated Haemoglobin ◽  
Lower Serum ◽  
Serum Vitamin D ◽  
Vitamin D Levels

Abstract Background. Type 1 diabetes (T1D) is an autoimmune chronic disease where hyperglycemia, increased risk of oxidative stress, advanced glycation end-products and other genetic and environmental factors lead to T1D complications. Shorter telomeres are associated with hyperglycemic levels and lower serum vitamin D levels. Methods. Average telomere length (ATL) in whole blood DNA samples was assessed with qPCR method in 53 Slovenian T1D children/adolescents (median age 8.7 years, 1:1.3 male/female ratio). Body mass index standard deviation score (BMI-SDS), glycated haemoglobin and serum level of vitamin D metabolite (25-(OH)-D3) and the age at the onset of T1D were collected from the available medical documentation. Results. Results indicate shorter ATL in subjects with higher BMI-SDS when compared to those with longer ATL (0.455 ± 0.438, -0.63 ± 0.295; p=0.049). Subjects with higher BMI-SDS had lower serum vitamin D levels when compared to those with lower BMI-SDS (40.66 ± 3.07 vs. 52.86 ± 4.85 nmol/L; p=0.045). Vitamin D serum levels did not significantly differ between subjects with longer/shorter ATL. Conclusion. T1D children/adolescents with shorter ATL tend to have higher BMI-SDS. Lower serum vitamin D levels were associated with higher BMI-SDS, while associations between vitamin D serum levels, age at the onset of T1D, glycated haemoglobin and ATL were not observed. Additional studies with more participants are required to clarify the role of the telomere dynamics in T1D aetiology and development of complications.

scholarly journals Dysregulation of the Intrarenal Vitamin D Endocytic Pathway in a Nephropathy-Prone Mouse Model of Type 1 Diabetes

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
John L. Fowlkes ◽  
R. Clay Bunn ◽  
Gael E. Cockrell ◽  
Lindsey M. Clark ◽  
Elizabeth C. Wahl ◽  
...  
Keyword(s):  
Vitamin D ◽  
Type 1 Diabetes ◽  
Target Genes ◽  
Diabetic Mouse ◽  
Endocytic Pathway ◽  
Diabetic Mice ◽  
Vitamin D Metabolism ◽  
25 Hydroxy Vitamin D ◽  
And Control

Microalbuminuria in humans with Type 1 diabetes (T1D) is associated with increased urinary excretion of megalin, as well as many megalin ligands, including vitamin-D-binding protein (VDBP). We examined the DBA/2J diabetic mouse, nephropathy prone model, to determine if megalin and VDBP excretion coincide with the development of diabetic nephropathy. Megalin, VDBP, and 25-hydroxy-vitamin D (25-OHD) were measured in urine, and genes involved in vitamin D metabolism were assessed in renal tissues from diabetic and control mice at 10, 15, and 18 weeks following the onset of diabetes. Megalin, VDBP, and 25-OHD were increased in the urine of diabetic mice. 1-α hydroxylase (CYP27B1) mRNA in the kidney was persistently increased in diabetic mice, as were several vitamin D-target genes. These studies show that intrarenal vitamin D handling is altered in the diabetic kidney, and they suggest that in T1D, urinary losses of VDBP may portend risk for intrarenal and extrarenal vitamin D deficiencies.

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