scholarly journals Manganese-Enhanced Magnetic Resonance Imaging Detects Declining Pancreatic β-Cell Mass in a Cyclophosphamide-Accelerated Mouse Model of Type 1 Diabetes

Diabetes ◽  
2012 ◽  
Vol 62 (1) ◽  
pp. 44-48 ◽  
Author(s):  
Patrick F. Antkowiak ◽  
Brian K. Stevens ◽  
Craig S. Nunemaker ◽  
Marcia McDuffie ◽  
Frederick H. Epstein
Keyword(s):  
Magnetic Resonance Imaging ◽  
Type 1 Diabetes ◽  
Magnetic Resonance ◽  
Mouse Model ◽  
Cell Mass ◽  
Pancreatic Β Cell ◽  
Resonance Imaging ◽  
Β Cell

scholarly journals Magnetic resonance imaging can diagnostic early morphofunctional changes in the myocardium in young people with type 1 diabetes

2019 ◽  
Vol 10 (1) ◽  
pp. 29-35
Author(s):  
Kirill A. Popov ◽  
Irina Z. Bondarenko ◽  
Elena V. Biryukova ◽  
Elena V. Averkieva ◽  
Alexander V. Vorontsov
Keyword(s):  
Magnetic Resonance Imaging ◽  
Type 1 Diabetes ◽  
Magnetic Resonance ◽  
Young People ◽  
Left Ventricle ◽  
Contrast Agent ◽  
Young Patients ◽  
Resonance Imaging ◽  
Functional Changes

Aim. To study the morphofunctional state of the myocardium in young people with diabetes mellitus 1 using magnetic resonance imaging (MRI) technology. Materials and methods. 38 patients (14 men, 24 women), aged 18 to 36 years old, with an experience of type 1 diabetes from 5 to 16 years old were underwent contrastive MRI of the heart. The exclusion criteria were: pronounced electrolyte disorders in the blood, dysproteinemia, chronic liver and kidney failure - glomerular filtration rate (EPI)≤60 ml/min/1.73 m2, thyroid dysfunction, obesity (body mass index ≥30 kg/m2), diagnosed cardiovascular diseases, contraindications for MRI. The indicators of functional changes in the left ventricle (circular strain, strain relaxation index - SRI), peak early diastolic strain (PSRDS) were obtained and the accumulation of the contrast agent in the delayed period were assessed. Results. The obtained results of strain, SRI, PSRDS do not allow to exclude the presence of functional changes in the myocardium of the left ventricle. In 42.11%, zones of accumulation of the contrast agent were visualized in the delayed period (insignificant - 28.95% and moderate accumulation - 13.16%), mainly by the endocardium of the cardiac apparatus (mitral and tricuspid), and in one observation (2.9%) - in combination with unexpressed diffuse heterogeneity of the myocardium of the left ventricle. Conclusion. MRI of the heart is a promising direction in the assessment of early morphofunctional changes in the structure of the myocardium, which will probably make it possible to predict life-threatening changes in the heart muscle in young patients with type 1 diabetes.

scholarly journals The Effects of Empagliflozin, an SGLT2 Inhibitor, on Pancreatic β-Cell Mass and Glucose Homeostasis in Type 1 Diabetes

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0147391 ◽  
Author(s):  
Sam Tsz Wai Cheng ◽  
Lihua Chen ◽  
Stephen Yu Ting Li ◽  
Eric Mayoux ◽  
Po Sing Leung
Keyword(s):  
Type 1 Diabetes ◽  
Glucose Homeostasis ◽  
Cell Mass ◽  
Sglt2 Inhibitor ◽  
Pancreatic Β Cell ◽  
Β Cell
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