scholarly journals A Cyclic Guanosine Monophosphate-Dependent Pathway Can Regulate Net Hepatic Glucose Uptake in Vivo

Diabetes ◽  
2012 ◽  
Vol 61 (10) ◽  
pp. 2433-2441 ◽  
Author(s):  
Z. An ◽  
J. J. Winnick ◽  
M. C. Moore ◽  
B. Farmer ◽  
M. Smith ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Cyclic Guanosine Monophosphate ◽  
Guanosine Monophosphate ◽  
Hepatic Glucose ◽  
Hepatic Glucose Uptake ◽  
Dependent Pathway

Factors Which Regulate Net Hepatic Glucose Uptake In Vivo

1991 ◽  
Vol 15 (3) ◽  
pp. 71S-73S ◽  
Author(s):  
Alan D. Cherrington ◽  
Michael J. Pagliassotti ◽  
Sharon R. Myers ◽  
Bess Adkins-Marshall ◽  
Owen P. Mcguinness
Keyword(s):  
Glucose Uptake ◽  
Hepatic Glucose ◽  
Hepatic Glucose Uptake

scholarly journals A physiological increase in the hepatic glycogen level does not affect the response of net hepatic glucose uptake to insulin

2009 ◽  
Vol 297 (2) ◽  
pp. E358-E366 ◽  
Author(s):  
Jason J. Winnick ◽  
Zhibo An ◽  
Mary Courtney Moore ◽  
Christopher J. Ramnanan ◽  
Ben Farmer ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Glycogen Synthesis ◽  
Control Period ◽  
In Vivo Studies ◽  
Hepatic Glycogen ◽  
Glycogen Level ◽  
Hepatic Glucose ◽  
Glycogen Deposition ◽  
Hepatic Glucose Uptake

To determine the effect of an acute increase in hepatic glycogen on net hepatic glucose uptake (NHGU) and disposition in response to insulin in vivo, studies were performed on two groups of dogs fasted 18 h. During the first 4 h of the study, somatostatin was infused peripherally, while insulin and glucagon were replaced intraportally in basal amounts. Hyperglycemia was brought about by glucose infusion, and either saline ( n = 7) or fructose ( n = 7; to stimulate NHGU and glycogen deposition) was infused intraportally. A 2-h control period then followed, during which the portal fructose and saline infusions were stopped, allowing NHGU and glycogen deposition in the fructose-infused animals to return to rates similar to those of the animals that received the saline infusion. This was followed by a 2-h experimental period, during which hyperglycemia was continued but insulin infusion was increased fourfold in both groups. During the initial 4-h glycogen loading period, NHGU averaged 1.18 ± 0.27 and 5.55 ± 0.53 mg·kg−1·min−1 and glycogen synthesis averaged 0.72 ± 0.24 and 3.98 ± 0.57 mg·kg−1·min−1 in the saline and fructose groups, respectively ( P < 0.05). During the 2-h hyperinsulinemic period, NHGU rose from 1.5 ± 0.4 and 0.9 ± 0.2 to 3.1 ± 0.6 and 2.5 ± 0.5 mg·kg−1·min−1 in the saline and fructose groups, respectively, a change of 1.6 mg·kg−1·min−1 in both groups despite a significantly greater liver glycogen level in the fructose-infused group. Likewise, the metabolic fate of the extracted glucose (glycogen, lactate, or carbon dioxide) was not different between groups. These data indicate that an acute physiological increase in the hepatic glycogen content does not alter liver glucose uptake and storage under hyperglycemic/hyperinsulinemic conditions in the dog.

Kupffer cells play a major role in insulin-mediated hepatic glucose uptake in vivo

1992 ◽  
Vol 186 (1) ◽  
pp. 455-460 ◽  
Author(s):  
Zoltán Spolarics ◽  
Aurél Ottlakán ◽  
Charles H. Lang ◽  
John J. Spitzer
Keyword(s):  
Glucose Uptake ◽  
Kupffer Cells ◽  
Hepatic Glucose ◽  
Hepatic Glucose Uptake

scholarly journals Regulation of Hepatic Glucose Uptake and Storage In Vivo

2012 ◽  
Vol 3 (3) ◽  
pp. 286-294 ◽  
Author(s):  
Mary Courtney Moore ◽  
Katie C. Coate ◽  
Jason J. Winnick ◽  
Zhibo An ◽  
Alan D. Cherrington
Keyword(s):  
Glucose Uptake ◽  
Hepatic Glucose ◽  
Hepatic Glucose Uptake ◽  
And Storage

Effects of the nitric oxide donor SIN-1 on net hepatic glucose uptake in the conscious dog

2008 ◽  
Vol 294 (2) ◽  
pp. E300-E306 ◽  
Author(s):  
Zhibo An ◽  
Catherine A. DiCostanzo ◽  
Mary C. Moore ◽  
Dale S. Edgerton ◽  
Dominique P. Dardevet ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Glucose Uptake ◽  
Experimental Period ◽  
In Vivo Studies ◽  
Nitric Oxide Donor ◽  
Control Group ◽  
Hepatic Glucose ◽  
Carbon Retention ◽  
Hepatic Glucose Uptake

To determine the role of nitric oxide in regulating net hepatic glucose uptake (NHGU) in vivo, studies were performed on three groups of 42-h-fasted conscious dogs using a nitric oxide donor [3-morpholinosydnonimine (SIN-1)]. The experimental period was divided into period 1 (0–90 min) and period 2 (P2; 90–240 min). At 0 min, somatostatin was infused peripherally, and insulin (4-fold basal) and glucagon (basal) were given intraportally. Glucose was delivered intraportally (22.2 μmol·kg−1·min−1) and peripherally (as needed) to increase the hepatic glucose load twofold basal. At 90 min, an infusion of SIN-1 (4 μg·kg−1·min−1) was started in a peripheral vein (PeSin-1, n = 10) or the portal vein (PoSin-1, n = 12) while the control group received saline (SAL, n = 8). Both peripheral and portal infusion of SIN-1, unlike saline, significantly reduced systolic and diastolic blood pressure. Heart rate rose in PeSin-1 and PoSin-1 (96 ± 5 to 120 ± 10 and 88 ± 6 to 107 ± 5 beats/min, respectively, P < 0.05) but did not change in response to saline. NHGU during P2 was 31.0 ± 2.4 and 29.9 ± 2.0 μmol·kg−1·min−1 in SAL and PeSin-1, respectively but was 23.7 ± 1.7 in PoSin-1 ( P < 0.05). Net hepatic carbon retention during P2 was significantly lower in PoSin-1 than SAL or PeSin-1 (21.4 ± 1.2 vs. 27.1 ± 1.5 and 26.1 ± 1.0 μmol·kg−1·min−1). Nonhepatic glucose uptake did not change in response to saline or SIN-1 infusion. In conclusion, portal but not peripheral infusion of the nitric oxide donor SIN-1 inhibited NHGU.

Insulin, glucagon, and glucose as regulators of hepatic glucose uptake and production in vivo

1987 ◽  
Vol 3 (1) ◽  
pp. 307-332 ◽  
Author(s):  
A. D. Cherrington ◽  
R. W. Stevenson ◽  
K. E. Steiner ◽  
M. A. Davis ◽  
S. R. Myers ◽  
...  
Keyword(s):  
Glucose Uptake ◽  
Hepatic Glucose ◽  
Hepatic Glucose Uptake

Regulation of Net Hepatic Glucose Uptake in VIVO

1992 ◽  
Vol 54 (1) ◽  
pp. 847-860 ◽  
Author(s):  
M J Pagliassotti ◽  
A D Cherrington
Keyword(s):  
Glucose Uptake ◽  
Hepatic Glucose ◽  
Hepatic Glucose Uptake
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