scholarly journals Zinc Transporter 8 Autoantibodies and Their Association With SLC30A8 and HLA-DQ Genes Differ Between Immigrant and Swedish Patients With Newly Diagnosed Type 1 Diabetes in the Better Diabetes Diagnosis Study

Diabetes ◽  
2012 ◽  
Vol 61 (10) ◽  
pp. 2556-2564 ◽  
Author(s):  
A. J. Delli ◽  
F. Vaziri-Sani ◽  
B. Lindblad ◽  
H. Elding-Larsson ◽  
A. Carlsson ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Zinc Transporter ◽  
Diabetes Diagnosis ◽  
Newly Diagnosed ◽  
Zinc Transporter 8 ◽  
Hla Dq

scholarly journals Diabetes Antibody Standardization Program: First Proficiency Evaluation of Assays for Autoantibodies to Zinc Transporter 8

2011 ◽  
Vol 57 (12) ◽  
pp. 1693-1702 ◽  
Author(s):  
Vito Lampasona ◽  
Michael Schlosser ◽  
Patricia W Mueller ◽  
Alistair JK Williams ◽  
Janet M Wenzlau ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Zinc Transporter ◽  
Immunofluorescent Staining ◽  
Disease Prediction ◽  
Newly Diagnosed ◽  
Binding Assays ◽  
Zinc Transporter 8 ◽  
Polymorphic Variants ◽  
High Degree

BACKGROUND Zinc transporter 8 (ZnT8) is a recently identified major autoantigen in type 1 diabetes, and autoantibodies to ZnT8 (ZnT8A) are new markers for disease prediction and diagnosis. Here we report the results of the first international proficiency evaluation of ZnT8A assays by the Diabetes Antibody Standardization Program (DASP). METHODS After a pilot workshop in 2007, an expanded ZnT8A workshop was held in 2009, with 26 participating laboratories from 13 countries submitting results of 63 different assays. ZnT8A levels were measured in coded sera from 50 patients with newly diagnosed type 1 diabetes and 100 blood donor controls. Results were analyzed comparing area under the ROC curve (ROC-AUC), sensitivity adjusted to 95% specificity (AS95), concordance of sample ZnT8A positive or negative designation, and autoantibody levels. RESULTS ZnT8A radio binding assays (RBAs) based on combined immunoprecipitation of the 2 most frequent ZnT8 COOH-terminal domain polymorphic variants showed a median ROC-AUC of 0.848 [interquartile range (IQR) 0.796–0.878] and a median AS95 of 70% (IQR 60%–72%). These RBAs were more sensitive than assays using as antigen either 1 ZnT8 variant only or chimeric constructs joining NH2- and COOH-terminal domains, assays based on immunoprecipitation and bioluminescent detection, or assays based on immunofluorescent staining of cells transfected with full-length antigen. CONCLUSIONS The DASP workshop identified immunoprecipitation-based ZnT8A assays and antigen constructs that achieved both a high degree of sensitivity and specificity and were suitable for more widespread clinical application.

scholarly journals What has zinc transporter 8 autoimmunity taught us about type 1 diabetes?

Diabetologia ◽  
2019 ◽  
Vol 62 (11) ◽  
pp. 1969-1976 ◽  
Author(s):  
Claire L. Williams ◽  
Anna E. Long
Keyword(s):  
Type 1 Diabetes ◽  
Zinc Transporter ◽  
Zinc Transporter 8

The prevalence and predictive value of the SLC30A8 R325W polymorphism and zinc transporter 8 autoantibodies in the development of GDM and postpartum type 1 diabetes

Endocrine ◽  
2016 ◽  
Vol 53 (3) ◽  
pp. 740-746 ◽  
Author(s):  
Jonatan Dereke ◽  
Sanna Palmqvist ◽  
Charlotta Nilsson ◽  
Mona Landin–Olsson ◽  
Magnus Hillman
Keyword(s):  
Type 1 Diabetes ◽  
Predictive Value ◽  
Zinc Transporter ◽  
Zinc Transporter 8

scholarly journals Humoral Responses to Islet Antigen-2 and Zinc Transporter 8 Are Attenuated in Patients Carrying HLA-A*24 Alleles at the Onset of Type 1 Diabetes

Diabetes ◽  
2013 ◽  
Vol 62 (6) ◽  
pp. 2067-2071 ◽  
Author(s):  
A. E. Long ◽  
K. M. Gillespie ◽  
R. J. Aitken ◽  
J. C. Goode ◽  
P. J. Bingley ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Zinc Transporter ◽  
Zinc Transporter 8 ◽  
Humoral Responses ◽  
Islet Antigen

Zinc transporter 8 autoantibodies in fulminant, acute-onset, and slow-onset patients with type 1 diabetes

2011 ◽  
Vol 27 (8) ◽  
pp. 895-898 ◽  
Author(s):  
Eiji Kawasaki ◽  
Kan Nakamura ◽  
Genpei Kuriya ◽  
Tsuyoshi Satoh ◽  
Masakazu Kobayashi ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Acute Onset ◽  
Zinc Transporter ◽  
Zinc Transporter 8 ◽  
Slow Onset

scholarly journals Changes in Zinc Transporter 8 Autoantibodies Following Type 1 Diabetes Onset: The Type 1 Diabetes Genetics Consortium Autoantibody Workshop

Diabetes Care ◽  
2015 ◽  
Vol 38 (Supplement 2) ◽  
pp. S14-S20 ◽  
Author(s):  
Janet M. Wenzlau ◽  
Lisa M. Frisch ◽  
John C. Hutton ◽  
Pamela R. Fain ◽  
Howard W. Davidson
Keyword(s):  
Type 1 Diabetes ◽  
Zinc Transporter ◽  
Diabetes Onset ◽  
Zinc Transporter 8 ◽  
Diabetes Genetics

scholarly journals Cognitive Function following Diabetic Ketoacidosis in Children with New Onset or Previously Diagnosed Type 1 Diabetes

2020 ◽  
Author(s):  
Simona Ghetti ◽  
Nathan Kuppermann ◽  
Arleta Rewers ◽  
Sage R. Myers ◽  
Jeff E. Schunk ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Diabetic Ketoacidosis ◽  
Hemoglobin A1c ◽  
Economic Status ◽  
Digit Span ◽  
Diabetes Diagnosis ◽  
Newly Diagnosed ◽  
Neurocognitive Assessment ◽  
New Onset

<b>Objective. </b>This study assessed whether a single diabetic ketoacidosis (DKA) episode is associated with cognitive declines in children with newly diagnosed type 1 diabetes, and whether the same is true in children who had been previously diagnosed after accounting for variations in glycemic control and other relevant factors.<b> Design. </b>We prospectively enrolled 758 children, 6- to 18-years-old, who presented with DKA in a randomized multi-site clinical trial evaluating intravenous fluid protocols for DKA treatment. DKA was moderate/severe in 430 children and mild in 328 children. 392 children with DKA had new onset of type 1 diabetes, and the rest were previously diagnosed. Neurocognitive assessment occurred 2-6 months after the DKA episode. A comparison group of 376 children with type 1 diabetes, but no DKA exposure, was also enrolled. <b>Results. </b>Among all patients, moderate/severe DKA was associated with lower IQ (β=-.12, p<0.001), item-color recall (β=-0.08, p=0.010), and forward digit span (β=-0.06, p=0.04). Among newly diagnosed patients, moderate/severe DKA was associated with lower item-color recall (β=-0.08, p=0.04). Among previously diagnosed patients, repeated DKA exposure and higher hemoglobin A1c were independently associated with lower IQ (β=-.10 and β=-0.09, respectively, ps <.01) and higher hemoglobin A1c was associated with lower item-color recall (β=-0.10, p=0.007), after accounting for hypoglycemia, diabetes duration, and socio-economic status.<b> Conclusion. </b>A single DKA episode is associated with subtle memory declines soon after type 1 diabetes diagnosis. Sizable IQ declines are detectable in children with known diabetes, suggesting that DKA effects may be exacerbated in children with chronic exposure to hyperglycemia.<b> <br> </b>

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