Protein Kinase C  Phosphorylates Occludin Regulating Tight Junction Trafficking in Vascular Endothelial Growth Factor-Induced Permeability In Vivo

T. Murakami; T. Frey; C. Lin; D. A. Antonetti

doi:10.2337/db11-1367

Protein Kinase C Phosphorylates Occludin Regulating Tight Junction Trafficking in Vascular Endothelial Growth Factor-Induced Permeability In Vivo

Diabetes ◽

10.2337/db11-1367 ◽

2012 ◽

Vol 61 (6) ◽

pp. 1573-1583 ◽

Cited By ~ 86

Author(s):

T. Murakami ◽

T. Frey ◽

C. Lin ◽

D. A. Antonetti

Keyword(s):

Vascular Endothelial Growth Factor ◽

Protein Kinase C ◽

Growth Factor ◽

Protein Kinase ◽

Tight Junction ◽

Vascular Endothelial ◽

Kinase C ◽

Endothelial Growth Factor

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Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor

Diabetes ◽

10.2337/diabetes.46.9.1473 ◽

1997 ◽

Vol 46 (9) ◽

pp. 1473-1480 ◽

Cited By ~ 127

Author(s):

L. P. Aiello ◽

S. E. Bursell ◽

A. Clermont ◽

E. Duh ◽

H. Ishii ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Protein Kinase C ◽

Growth Factor ◽

Protein Kinase ◽

Selective Inhibitor ◽

Vascular Endothelial ◽

Kinase C ◽

Endothelial Growth Factor

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Vascular Endothelial Growth Factor-Induced Retinal Permeability is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective β-Isoform-Selective Inhibitor.

Retina ◽

10.1097/00006982-199805000-00033 ◽

1998 ◽

Vol 18 (5) ◽

pp. 492

Author(s):

L P Aiello ◽

S E Bursell ◽

A Clermont ◽

E Duh ◽

H Ishii ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Protein Kinase C ◽

Growth Factor ◽

Protein Kinase ◽

Selective Inhibitor ◽

Vascular Endothelial ◽

Kinase C ◽

Endothelial Growth Factor

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Vascular Endothelial Growth Factor-Induced Retinal Permeability Is Mediated by Protein Kinase C In Vivo and Suppressed by an Orally Effective -Isoform-Selective Inhibitor

Diabetes ◽

10.2337/diab.46.9.1473 ◽

1997 ◽

Vol 46 (9) ◽

pp. 1473-1480 ◽

Cited By ~ 328

Author(s):

L. P. Aiello ◽

S.-E. Bursell ◽

A. Clermont ◽

E. Duh ◽

H. Ishii ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Protein Kinase C ◽

Growth Factor ◽

Protein Kinase ◽

Selective Inhibitor ◽

Vascular Endothelial ◽

Kinase C ◽

Endothelial Growth Factor

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Blood-retinal barrier breakdown induced by activation of protein kinase C via vascular endothelial growth factor in streptozotocin-induced diabetic rats

Current Eye Research ◽

10.1076/ceyr.28.4.251.27834 ◽

2004 ◽

Vol 28 (4) ◽

pp. 251-256 ◽

Cited By ~ 44

Author(s):

Xun Xu ◽

Qi Zhu ◽

Xin Xia ◽

Shijie Zhang ◽

Qing Gu ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Protein Kinase C ◽

Growth Factor ◽

Protein Kinase ◽

Diabetic Rats ◽

Vascular Endothelial ◽

Blood Retinal Barrier ◽

Kinase C ◽

Barrier Breakdown ◽

Endothelial Growth Factor

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Protein kinase C promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor

Cardiovascular Research ◽

10.1093/cvr/cvm085 ◽

2008 ◽

Vol 78 (2) ◽

pp. 349-355 ◽

Cited By ~ 52

Author(s):

H. Xu ◽

P. Czerwinski ◽

M. Hortmann ◽

H.-Y. Sohn ◽

U. Forstermann ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Endothelial Cells ◽

Protein Kinase C ◽

Growth Factor ◽

Protein Kinase ◽

Vascular Endothelial ◽

Human Endothelial Cells ◽

Angiogenic Activity ◽

Kinase C ◽

Endothelial Growth Factor

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Decay-accelerating Factor Induction on Vascular Endothelium by Vascular Endothelial Growth Factor (VEGF) Is Mediated via a VEGF Receptor-2 (VEGF-R2)- and Protein Kinase C-α/ϵ (PKCα/ϵ)-dependent Cytoprotective Signaling Pathway and Is Inhibited by Cyclosporin A

Journal of Biological Chemistry ◽

10.1074/jbc.m407981200 ◽

2004 ◽

Vol 279 (40) ◽

pp. 41611-41618 ◽

Cited By ~ 43

Author(s):

Justin C. Mason ◽

Rivka Steinberg ◽

Elaine A. Lidington ◽

Anne R. Kinderlerer ◽

Motoi Ohba ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Protein Kinase C ◽

Growth Factor ◽

Protein Kinase ◽

Cyclosporin A ◽

Vascular Endothelium ◽

Vegf Receptor ◽

Vascular Endothelial ◽

Kinase C ◽

Endothelial Growth Factor

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Vascular Endothelial Growth Factor (VEGF) Attenuates Hyperoxia Via Neuropilin-1 (nrp)-Protein Kinase C (pkc) Dependent Pathway In Explanted Embryonic Lung

10.1164/ajrccm-conference.2011.183.1_meetingabstracts.a2100 ◽

2011 ◽

Author(s):

Americo E. Esquibies ◽

Alia Bazzy-Asaad ◽

Lloyd G. Cantley

Keyword(s):

Vascular Endothelial Growth Factor ◽

Protein Kinase C ◽

Growth Factor ◽

Protein Kinase ◽

Vascular Endothelial ◽

Embryonic Lung ◽

Kinase C ◽

Neuropilin 1 ◽

Endothelial Growth Factor ◽

Dependent Pathway

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Vascular endothelial growth factor (VEGF) isoform attenuates hyperoxic injury of embryonic lung via a Flk1–neuropilin (Nrp)-1–protein kinase C (PKC) dependent pathway

Paediatric Respiratory Reviews ◽

10.1016/s1526-0542(13)70141-6 ◽

2013 ◽

Vol 14 ◽

pp. S79-S80

Author(s):

A.E. Esquibies ◽

A. Karihaloo ◽

A. Bazzy-Asaad ◽

L.G. Cantley

Keyword(s):

Vascular Endothelial Growth Factor ◽

Protein Kinase C ◽

Growth Factor ◽

Protein Kinase ◽

Vascular Endothelial ◽

Embryonic Lung ◽

Kinase C ◽

Endothelial Growth Factor ◽

Dependent Pathway

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Activation of Sp1-mediated Vascular Permeability Factor/Vascular Endothelial Growth Factor Transcription Requires Specific Interaction with Protein Kinase C ζ

Journal of Biological Chemistry ◽

10.1074/jbc.273.41.26277 ◽

1998 ◽

Vol 273 (41) ◽

pp. 26277-26280 ◽

Cited By ~ 122

Author(s):

Soumitro Pal ◽

Kevin P. Claffey ◽

Herbert T. Cohen ◽

Debabrata Mukhopadhyay

Keyword(s):

Vascular Endothelial Growth Factor ◽

Protein Kinase C ◽

Growth Factor ◽

Protein Kinase ◽

Vascular Permeability ◽

Specific Interaction ◽

Vascular Endothelial ◽

Vascular Permeability Factor ◽

Kinase C ◽

Endothelial Growth Factor

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Vascular Endothelial Growth Factor Enhances the Expression of Urokinase Receptor in Human Endothelial Cells via Protein Kinase C Activation

Thrombosis and Haemostasis ◽

10.1055/s-0037-1615683 ◽

2001 ◽

Vol 85 (02) ◽

pp. 296-302 ◽

Cited By ~ 7

Author(s):

Marielle Kroon ◽

Pieter Koolwijk ◽

Mario Vermeer ◽

Bea van der Vecht ◽

Victor van Hinsbergh

Keyword(s):

Vascular Endothelial Growth Factor ◽

Endothelial Cells ◽

Protein Kinase C ◽

Growth Factor ◽

Protein Kinase ◽

Receptor Expression ◽

Vascular Endothelial ◽

Human Endothelial Cells ◽

Kinase C ◽

Endothelial Growth Factor

SummaryAmong other proteolytic enzymes, the urokinase-type plasminogen activator (u-PA)/plasmin cascade contributes to cell migration and the formation of capillary-like structures in a fibrinous exudate. The u-PA receptor (u-PAR) focuses proteolytical activity on the cell surface of the endothelial cell and hereby accelerates the pericellular matrix degradation. Vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF)-2 enhance u-PA receptor expression in human endothelial cells. In this paper we show that the protein kinase C (PKC) inhibitors Ro31-8220 and GF109203X inhibit VEGF165-induced u-PAR antigen expression in human endothelial cells, whereas PKC inhibition had no effect on FGF-2-induced u-PAR antigen enhancement. In addition, inhibition of PKC activity had no effect on VEGF165-or FGF-2-induced proliferation in human endothelial cells. We conclude that VEGF165 induces u-PAR via a PKC-dependent pathway, whereas proliferation is induced via a different pathway probably involving tyrosine phosphorylation of proteins downstream of the VEGF receptors.

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