scholarly journals Hypothalamic Neuropeptide Y (NPY) Controls Hepatic VLDL-Triglyceride Secretion in Rats via the Sympathetic Nervous System

Diabetes ◽  
2012 ◽  
Vol 61 (5) ◽  
pp. 1043-1050 ◽  
Author(s):  
Eveline Bruinstroop ◽  
Lei Pei ◽  
Mariëtte T. Ackermans ◽  
Ewout Foppen ◽  
Anke J. Borgers ◽  
...  
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Neuropeptide Y ◽  
Triglyceride Secretion ◽  
Sympathetic Nervous ◽  
Vldl Triglyceride

scholarly journals Central Nervous System Neuropeptide Y Signaling Modulates VLDL Triglyceride Secretion

Diabetes ◽  
2008 ◽  
Vol 57 (6) ◽  
pp. 1482-1490 ◽  
Author(s):  
J. M. Stafford ◽  
F. Yu ◽  
R. Printz ◽  
A. H. Hasty ◽  
L. L. Swift ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Neuropeptide Y ◽  
Triglyceride Secretion ◽  
Vldl Triglyceride

scholarly journals Effect of neuropeptide Y on hemodynamics of the rabbit lung

1998 ◽  
Vol 84 (2) ◽  
pp. 618-623 ◽  
Author(s):  
Sally A. Lang ◽  
Michael B. Maron
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Neuropeptide Y ◽  
Rabbit Lung ◽  
Vasoactive Agent ◽  
Arterial Resistance ◽  
Pulmonary Capillary ◽  
Intact Rabbit ◽  
Sympathetic Nervous ◽  
Potent Vasoconstrictor

Lang, Sally A., and Michael B. Maron.Effect of neuropeptide Y on hemodynamics of the rabbit lung. J. Appl. Physiol. 84(2): 618–623, 1998.—We evaluated the effect of neuropeptide Y (NPY) on the hemodynamics of the isolated rabbit lung perfused at constant flow and outflow pressure. Doses of 10−8 and 10− 7 M NPY increased pulmonary arterial pressure (Ppa) from 11.5 ± 1.0 (SE) mmHg to, respectively, 16.4 ± 1.5 and 26.0 ± 3.8 mmHg ( P < 0.05, n = 5 mmHg lungs), with 78 ± 4% of the increase at 10−7 M resulting from an increased arterial resistance. At the latter dose, pulmonary capillary pressure increased from 5.8 ± 0.9 to 9.4 ± 1.0 mmHg ( P < 0.05). When administered in the presence of norepinephrine, 10−8 and 10−7 M NPY ( n = 6) produced extreme increases in Ppa to 66.1 ± 20.5 and 114.7 ± 25.5 mmHg, respectively, that were due primarily to an increased arterial resistance. To determine the significance of circulating NPY as a pulmonary vasoactive agent, we measured plasma NPY-like immunoreactivity in anesthetized rabbits after massively activating the sympathetic nervous system with veratrine. NPY-like immunoreactivity increased from 74 ± 10 to 111 ± 10 (SE) pM ( P < 0.05). Thus, although NPY is a potent vasoconstrictor in the rabbit lung, it is not likely that plasma NPY concentrations rise sufficiently, even after massive sympathetic nervous system activation, to produce pulmonary vasoconstriction in the intact rabbit.

scholarly journals Rapid measurement of cardiac neuropeptide dynamics by capacitive immunoprobe in the porcine heart

2021 ◽  
Vol 320 (1) ◽  
pp. H66-H76
Author(s):  
Nicholas Kluge ◽  
Michael Dacey ◽  
Joseph Hadaya ◽  
Kalyanam Shivkumar ◽  
Shyue-An Chan ◽  
...  
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Cardiac Function ◽  
Neuropeptide Y ◽  
Cardiac Remodeling ◽  
Beating Heart ◽  
Porcine Heart ◽  
Rapid Measurement ◽  
Sympathetic Nervous

The sympathetic nervous system regulates cardiac function through release of neurotransmitters and neuropeptides within the myocardium. Neuropeptide Y (NPY) acts as an acute cardiac vasoconstrictor and chronically to regulate angiogenesis and cardiac remodeling. Current methodologies for the measure of NPY are not capable of providing rapid readouts on a single-sample basis. Here we provide the first in vivo methodology to report dynamic, localized NPY levels within both myocardium and vascular compartments in a beating heart.

scholarly journals Sympathetic nervous system-targeted neuropeptide Y overexpression in mice enhances neointimal formation in response to vascular injury

Peptides ◽  
2009 ◽  
Vol 30 (4) ◽  
pp. 715-720 ◽  
Author(s):  
Suvi T. Ruohonen ◽  
Ken Abe ◽  
Mia Kero ◽  
Laura Toukola ◽  
Saku Ruohonen ◽  
...  
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Neuropeptide Y ◽  
Vascular Injury ◽  
Neointimal Formation ◽  
Sympathetic Nervous

34 Neuropeptide Y, sympathetic nervous system, arterial hypertension and

1991 ◽  
Vol 9 (9) ◽  
pp. 882
Author(s):  
M F Poncet ◽  
G Tavernier ◽  
C Damase-Michel ◽  
M A Tran ◽  
M Berlan ◽  
...  
Keyword(s):  
Nervous System ◽  
Sympathetic Nervous System ◽  
Arterial Hypertension ◽  
Neuropeptide Y ◽  
Sympathetic Nervous
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