scholarly journals The Gly(972)Arg Variant of Human IRS1 Gene Is Associated With Variation in Glomerular Filtration Rate Likely Through Impaired Insulin Receptor Signaling

Diabetes ◽  
2012 ◽  
Vol 61 (9) ◽  
pp. 2385-2393 ◽  
Author(s):  
F. Thameem ◽  
S. Puppala ◽  
J. Schneider ◽  
B. Bhandari ◽  
R. Arya ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Insulin Receptor ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
Receptor Signaling ◽  
Impaired Insulin ◽  
Insulin Receptor Signaling

THE RENIN-ANGIOTENSIN SYSTEM IS ASSOCIATED WITH IMPAIRED INSULIN RECEPTOR SIGNALING IN BURN INJURY

Shock ◽  
2006 ◽  
Vol 25 (Supplement 1) ◽  
pp. 17
Author(s):  
S.O. Kasper ◽  
S.M. Castle ◽  
B. Voy ◽  
B.L. Enderson ◽  
B.J. Daley ◽  
...  
Keyword(s):  
Insulin Receptor ◽  
Burn Injury ◽  
Renin Angiotensin System ◽  
Receptor Signaling ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Impaired Insulin ◽  
Insulin Receptor Signaling

scholarly journals A Polymorphism in the Gene Encoding the Insulin Receptor Binding Protein ENPP-1 Is Associated with Decreased Glomerular Filtration Rate in an Under-Investigated Indigenous African Population

2020 ◽  
Vol 45 (6) ◽  
pp. 1009-1017
Author(s):  
Eleanor M. Cave ◽  
Katherine L. Prigge ◽  
Nigel J. Crowther ◽  
Jaya A. George ◽  
Carolyn J. Padoa
Keyword(s):  
Insulin Resistance ◽  
Glomerular Filtration Rate ◽  
Insulin Receptor ◽  
Glomerular Filtration ◽  
South African ◽  
Kidney Function ◽  
Filtration Rate ◽  
Thyroid Stimulating Hormone ◽  
Black South African ◽  
Lower Egfr

<b><i>Introduction:</i></b> The C allele of the ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP-1) rs1044498 polymorphism has previously been associated with increased binding of ENPP-1 to the insulin receptor (IR), resulting in decreased IR signalling and enhanced insulin resistance. It has also been associated with reduced kidney function in participants with diabetes of predominantly European and Asian descent. The association of this polymorphism with kidney disease in healthy Black South African participants has yet to be ascertained. <b><i>Objective:</i></b> This study, therefore, aimed to determine whether the K121Q polymorphism is associated with estimated glomerular filtration rate (eGFR) in a Black South African cohort. <b><i>Methods:</i></b> Black South African participants (<i>n</i> = 348) from an existing cohort with known eGFR levels were genotyped for the K121Q polymorphism using PCR-RFLP and assessed for any statistical association between genotype and kidney function. <b><i>Results:</i></b> Individuals with the A allele had significantly lower eGFR levels than individuals with the CC genotype (86.52 ± 18.95 vs. 93.29 ± 23.55 mL/min; <i>p</i> = 0.022). The association of the A allele with lower eGFR levels remained after controlling for sex, blood pressure, insulin resistance, age, smoking, thyroid-stimulating hormone, insulin-like growth factor-1, and BMI (<i>R</i><sup>2</sup> = 0.030, <i>p</i> &#x3c; 0.001). <b><i>Conclusion:</i></b> The rs1044498 A allele was significantly associated with lower eGFR levels in a cohort of apparently healthy Black South Africans, through an unknown mechanism that was independent of insulin resistance. It is possible that the rs1044498 polymorphism affects kidney function by altering the role of ENPP-1 in endothelial wound healing, podocyte signalling, or oxidative stress. Thus, the presence of this polymorphism may predispose individuals to a greater risk of CKD even in the absence of diabetes.

Clinical Renal Function Testing by External Double Isotope Monitoring Technique

1971 ◽  
Vol 10 (01) ◽  
pp. 16-24
Author(s):  
J. Fog Pedersen ◽  
M. Fog Pedersen ◽  
Paul Madsen
Keyword(s):  
Renal Function ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Correlation Coefficients ◽  
Feedback System ◽  
Effective Renal Plasma Flow ◽  
Advantages And Disadvantages

SummaryAn accurate catheter-free technique for clinical determination simultaneouslyof glomerular filtration rate and effective renal plasma flow by means of radioisotopes has been developed. The renal function is estimated by the amount of radioisotopes necessary to maintain a constant concentration in the patient’s blood. The infusion pumps are steered by a feedback system, the pumps being automatically turned on when the radiation measured over the patient’s head falls below a certain preset level and turned off when this level is again readied. 131I-iodopyracet was used for the estimation of effective renal plasma flow and125I-iothalamate estimation of the glomerular filtration rate. These clearances were compared to the conventional bladder clearances and good correlation was found between these two clearance methods (correlation coefficients 0.97 and.90 respectively). The advantages and disadvantages of this new clearance technique are discussed.

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