scholarly journals Diabetic Visceral Hypersensitivity Is Associated With Activation of Mitogen-Activated Kinase in Rat Dorsal Root Ganglia

Diabetes ◽  
2011 ◽  
Vol 60 (6) ◽  
pp. 1743-1751 ◽  
Author(s):  
G. Grabauskas ◽  
A. Heldsinger ◽  
X. Wu ◽  
D. Xu ◽  
S. Zhou ◽  
...  
Keyword(s):  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Visceral Hypersensitivity

scholarly journals Electroacupuncture and Moxibustion Modulate the BDNF and TrkB Expression in the Colon and Dorsal Root Ganglia of IBS Rats with Visceral Hypersensitivity

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Duiyin Jin ◽  
Yanan Liu ◽  
Siyi Lv ◽  
Qin Qi ◽  
Mei Li ◽  
...  
Keyword(s):  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
The Body ◽  
Visceral Hypersensitivity ◽  
Mustard Oil ◽  
Rat Colon ◽  
Tyrosine Kinase Receptor ◽  
Once Daily ◽  
Mild Moxibustion ◽  
Pinaverium Bromide

Objective. To evaluate the effects of electroacupuncture and moxibustion on brain-derived neurotrophic factor (BDNF) and its receptor tyrosine kinase receptor B (TrkB) protein and mRNA expressions in the colon and dorsal root ganglia of IBS rats with visceral hypersensitivity and to explore their underlying therapeutic mechanisms. Method. Forty Sprague Dawley rats were randomly divided into normal, model, model + mild moxibustion (MM), model + electroacupuncture (EA), and model + pinaverium bromide (PB) groups, with eight rats in each group. Chronic visceral hypersensitive IBS rat models were established by colorectal distension (CRD) with mustard oil clyster. Rats in the MM and EA groups, respectively, received moxibustion and electroacupuncture treatments on the Tianshu (ST25) and Shangjuxu (ST37) acupoints once daily for 7 days, and rats in the PB group received pinaverium bromide by oral gavage once daily for 7 consecutive days. After treatment, rats underwent abdominal withdrawal reflex (AWR) scoring under CRD and colon histopathological examination. Immunohistochemistry and real-time quantitative PCR (RT-qPCR) were used to study the protein and mRNA expressions of BDNF and TrkB in the rat colon and dorsal root ganglia. Results. Compared with the normal group, AWR scores and body weight were clearly increased in the model group rats (both P < 0.01 ). The body weights were significantly elevated ( P < 0.01 , P < 0.05 ), but the AWR scores were reduced ( P < 0.05 , P < 0.01 ), after electroacupuncture and mild moxibustion treatment. Compared with levels in normal rats, BDNF and TrkB protein and mRNA expressions were significantly elevated in the IBS model rats ( P < 0.01 ) but were downregulated after mild moxibustion, electroacupuncture, and Western medicine treatment ( P < 0.01 ). Conclusion. Electroacupuncture and moxibustion improved visceral hypersensitivity of IBS rats possibly by reducing BDNF and TrkB protein and mRNA expressions in the colon and dorsal root ganglia.

1009 – Sensory Neuroplasticity in the Dorsal Root Ganglia Accounts for Persistent Visceral Hypersensitivity After Colon Obstruction

2019 ◽  
Vol 156 (6) ◽  
pp. S-218
Author(s):  
You-Min Lin ◽  
Yu Fu ◽  
Shrilakshmi Hegde ◽  
Kangling Zhang ◽  
Ravi Radhakrishnan ◽  
...  
Keyword(s):  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Visceral Hypersensitivity ◽  
Colon Obstruction

scholarly journals Decreased miR-325-5p Contributes to Visceral Hypersensitivity Through Post-transcriptional Upregulation of CCL2 in Rat Dorsal Root Ganglia

2019 ◽  
Vol 35 (5) ◽  
pp. 791-801 ◽  
Author(s):  
Rui Wu ◽  
Ping-An Zhang ◽  
Xuelian Liu ◽  
Yuan Zhou ◽  
Meijie Xu ◽  
...  
Keyword(s):  
Dorsal Root Ganglia ◽  
Dorsal Root ◽  
Visceral Hypersensitivity

Membrane-associated microtubular areays induced in proximal myelinated processes of dorsal root ganglia by large doses of vitamin B6

1986 ◽  
Vol 44 ◽  
pp. 368-369
Author(s):  
V.J. Montpetit ◽  
S. Dancea ◽  
L. Tryphonas ◽  
D.F. Clapin
Keyword(s):  
Animal Model ◽  
Endoplasmic Reticulum ◽  
Dorsal Root Ganglia ◽  
Rough Endoplasmic Reticulum ◽  
Dorsal Root ◽  
Vitamin B6 ◽  
Morphological Changes ◽  
Model System ◽  
Sensory Nerves ◽  
Peripheral Sensory

Very large doses of pyridoxine (vitamin B6) are neurotoxic in humans, selectively affecting the peripheral sensory nerves. We have undertaken a study of the morphological and biochemical aspects of pyridoxine neurotoxicity in an animal model system. Early morphological changes in dorsal root ganglia (DRG) associated with pyridoxine megadoses include proliferation of neurofilaments, ribosomes, rough endoplasmic reticulum, and Golgi complexes. We present in this report evidence of the formation of unique aggregates of microtubules and membranes in the proximal processes of DRG which are induced by high levels of pyridoxine.

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